Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells

Schwartz, A; McCrackin, Mary Ann; Schinazi, Raymond F.; Hill, Peter; Vahlenkamp, Thomas W.; Tompkins, Mary B.; Hartmann, Katrin

doi:10.2460/ajvr.75.3.273

Cited by 15 publications

(17 citation statements)

References 100 publications

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“…Os fármacos abacavir (ABC), emtricitabina (FTC), estavudina (D4T) e zalcitabina (DDC) da classe dos ITRN e os inibidores de protease (IP) atazanavir, lopinavir e tipranavir demonstraram atividade antiviral in vitro diante do FIV e apresentam-se como antirretrovirais potenciais para futuros estudos in vivo em gatos FIV positivos (BALZARINI et al, 1996;BISSET et al, 2002;MEDLIN et al, 1996;NORELLI et al, 2008;SCHWARTZ et al, 2014).…”

Section: Antirretrovirais Com Potencial Atividade Antiviral In Vivo Dunclassified

Terapia Antirretroviral No Controle Da Infecção Pelo Vírus Da Imunodeficiência Felina: Revisão E Perspectivas

Silva

Vargas

et al. 2017

SCI. ANIM. HEALTH

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O vírus da imunodeficiência felina (FIV) pertence à família Retroviridae e apresenta estrutura molecular e patogenia similar ao vírus da imunodeficiência humana (HIV). A infecção pelo FIV pode determinar síndrome de imunodeficiência adquirida em gatos (AIDS felina). A eficácia do tratamento em humanos com HIV é obtida com uma combinação de drogas com diferentes mecanismos de ação que promovem a inibição de fases críticas do ciclo de replicação dos retrovírus, sendo tal esquema terapêutico denominado pela sigla HAART (Highly Active Antiretroviral Therapy). Antirretrovirais como zidovudina, lamivudina, fozivudina, estampidina, TL3 e plerixafor foram testados in vivo frente ao FIV no regime de monoterapia e induziram supressão de carga viral. Seguindo a tendência de tratamento anti-HIV, futuros estudos devem testar fármacos antirretrovirais em regime de associação, com o propósito de desenvolver um protocolo HAART em medicina felina. A presente revisão tem o objetivo de discutir e propor condutas na terapia antirretroviral (TARV) em felinos, além de apresentar os principais fármacos antirretrovirais com eficácia comprovada frente ao FIV.

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Section: Antirretrovirais Com Potencial Atividade Antiviral In Vivo Dunclassified

Terapia Antirretroviral No Controle Da Infecção Pelo Vírus Da Imunodeficiência Felina: Revisão E Perspectivas

Silva

Vargas

et al. 2017

SCI. ANIM. HEALTH

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“…The anti-FIV activity of zidovudine has been assessed in numerous in vitro studies in different cell systems [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. The first in vitro study was carried out in 1989, when North and coworkers showed that zidovudine inhibited FIV replication in Crandell-Rees feline kidney (CRFK) cells.…”

Section: Nucleoside Analogue Reverse Transcriptase Inhibitorsmentioning

confidence: 99%

“…Stavudine is active against FIV in vitro [ 18 , 19 , 20 , 23 , 26 , 35 , 36 ]. Mutants of FIV that are resistant to stavudine and cross-resistant to several other antivirals, including zidovudine, have been detected.…”

Section: Nucleoside Analogue Reverse Transcriptase Inhibitorsmentioning

confidence: 99%

“…Didanosine is active against FIV in vitro [ 14 , 18 , 20 , 21 , 22 , 23 , 24 , 26 , 38 ]. In one experimental in vivo study, FIV replication was significantly suppressed in animals treated with didanosine, but treatment contributed to the development of antiretroviral toxic neuropathy [ 39 ].…”

Section: Nucleoside Analogue Reverse Transcriptase Inhibitorsmentioning

confidence: 99%

“…Lamivudine is active against FIV in vitro [ 3 , 20 , 21 , 23 , 38 , 41 ]. A combination of zidovudine and lamivudine had synergistic anti-FIV activities in cell cultures [ 41 ].…”

Section: Nucleoside Analogue Reverse Transcriptase Inhibitorsmentioning

confidence: 99%

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Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus

Hartmann¹,

Wooding²,

Bergmann³

2015

Veterinary Sciences

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Feline immunodeficiency virus (FIV) is one of the most common infectious agents affecting cats worldwide .FIV and human immunodeficiency virus (HIV) share many properties: both are lifelong persistent lentiviruses that are similar genetically and morphologically and both viruses propagate in T-lymphocytes, macrophages, and neural cells. Experimentally infected cats have measurable immune suppression, which sometimes progresses to an acquired immunodeficiency syndrome. A transient initial state of infection is followed by a long latent stage with low virus replication and absence of clinical signs. In the terminal stage, both viruses can cause severe immunosuppression. Thus, FIV infection in cats has become an important natural model for studying HIV infection in humans, especially for evaluation of antiviral compounds. Of particular importance for chemotherapeutic studies is the close similarity between the reverse transcriptase (RT) of FIV and HIV, which results in high in vitro susceptibility of FIV to many RT-targeted antiviral compounds used in the treatment of HIV-infected patients. Thus, the aim of this article is to provide an up-to-date review of studies on antiviral treatment of FIV, focusing on commercially available compounds for human or animal use.

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Antivirals: Past, Present and Future

Bule

Khan

Niaz

2019

Recent Advances in Animal Virology

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The uses of antiviral agents are increasing in the new era along with the development of vaccines for the effective control of viral diseases. The main aims of antiviral agents are to minimize harm to the host system and eradicate deadly viral diseases. However, the replications of viruses in host system represent a massive therapeutic challenge than bacteria and fungi. Antiviral drugs not just penetrate to disrupt the virus' cellular divisions but also have a negative impact on normal physiological pathways in the host. Due to these issues, antiviral agents have a narrow therapeutic index than antibacterial drugs. Nephrotoxicity is the main adverse reaction of antiviral drugs in human and animals. In this chapter, we summarize the antiviral agents' past, present and future perspectives with the main focus on the brief history of antiviral in animals, miscellaneous drugs, natural products, herbal and repurposing drugs.

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Antiviral efficacy of nine nucleoside reverse transcriptase inhibitors against feline immunodeficiency virus in feline peripheral blood mononuclear cells

Cited by 15 publications

References 100 publications

Terapia Antirretroviral No Controle Da Infecção Pelo Vírus Da Imunodeficiência Felina: Revisão E Perspectivas

Terapia Antirretroviral No Controle Da Infecção Pelo Vírus Da Imunodeficiência Felina: Revisão E Perspectivas

Efficacy of Antiviral Drugs against Feline Immunodeficiency Virus

Antivirals: Past, Present and Future

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