Antiviral Essential Oils Incorporated in Nanocarriers: Strategy for Prevention from COVID-19 and Future Infectious Pandemics

Kaur, Malkiet; Devi, Gayatri; Nagpal, Manju; Singh, Manjinder; Dhingra, Gitika Arora; Aggarwal, Geeta

doi:10.2174/2211738508666201016151850

Cited by 21 publications

(8 citation statements)

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“…[32][33][34] In this context, nanoflora-nanoparticles improving bioactive compounds′ bioavailability-was reported to enhance the delivery of insoluble phytochemicals repurposing antimicrobial drugs, [35][36][37] including therapeutics approaches against viruses [38][39][40] and and coronaviruses (CoVs). [41,42] However, only after the COVID-19 emergence, a considerable number of papers has been published on nanomaterialsbased platforms and coronaviruses, although the first studies initiate after the first coronavirus pandemic, the 2002-2004 severe acute respiratory syndrome (SARS)-Figure 1 shows the number of publications retrieved in a simple search in some databases related to the topics "nano" and "coronavirus" between January 1, 2004 and December 31, 2020.…”

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confidence: 99%

Recent Advances on Nanomaterials to COVID‐19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS‐CoV‐2 Inhibition/Inactivation

Carvalho

Conté-Júnior

2021

Global Challenges

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A novel beta-coronavirus, the novel coronavirus (SARS-CoV-2), or the severe acute respiratory syndrome coronavirus 2, was described as the causative agent of the pneumonia outbreak of coronavirus disease 2019 (COVID-19), first reported in December 2019 in a local seafood market of Wuhan, Hubei province, China. [1,2] The same beta-coronavirus genus of SARS-CoV-2 was earlier the causative of viral pneumonia pandemics caused by severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) that emerged in 2002 in China and 2012 in the Arabian Peninsula, respectively. [3] The World Health Organization reported, globally, as of 30 January 2021, more than 101 million confirmed cases of COVID-19 and 2 196 944 deaths. [4] Due to lockdown and quarantine, humanity is now facing its worst economic crisis since World WarThe current pandemic of coronavirus disease 2019 (COVID-19) is recognized as a public health emergency of worldwide concern. Nanomaterials can be effectively used to detect, capture/inactivate or inhibit coronavirus cell entry/ replication in the human host cell, preventing infection. Their potential for nanovaccines, immunoengineering, diagnosis, repurposing medication, and disinfectant surfaces targeting the novel coronavirus (SARS-CoV-2) is highlighted. In this systematic review the aim is to present an unbiased view of which and how nanomaterials can reduce the spread of COVID-19. Herein, the focus is on SARS-CoV-2, analyzing 46 articles retrieved before December 31, 2020. The interface between nanomaterials is described, and the main mechanisms to inhibit SARS-CoV-2 pathogenesis and viral inactivation are also discussed. Nanocarbons, biopolymeric, copper, and silver nanoparticles are potential antiviral and virucidal agents toward self-cleaning and reusable filter media and surfaces (e.g., facial masks), drug administration, vaccines, and immunodiagnostic assays. Trends in toxicology research and safety tests can help fill the main gaps in the literature and overcome health surveillance's challenges. Phytochemicals delivery by nanocarriers also stand out as candidates to target and bio-friendly therapy. Nanocellulose might fill in the gaps. Future research using nanomaterials targeting novel therapies/prophylaxis measures to COVID-19 and future outbreaks is discussed.

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confidence: 99%

Recent Advances on Nanomaterials to COVID‐19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS‐CoV‐2 Inhibition/Inactivation

Carvalho

Conté-Júnior

2021

Global Challenges

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“…In addition, two controlled clinical trials have been registered to assess the efficacy of plant-derived essential oils against asymptomatic and symptomatic COVID-19 patients ( Trial ID: CTRI/2021/07/034962 ) in India, and post-COVID-19 fatigue ( ClinicalTrials.gov identifier: NCT04980573 ) in the United States. Above all else, active constituents in essential oils such as phenols, terpenoids, alkaloids, and phenylpropanoids possess potent antiviral properties and are safe for human use with fewer side effects [ 62 ].…”

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confidence: 99%

Role of ethno-phytomedicine knowledge in healthcare of COVID-19: advances in traditional phytomedicine perspective

Ahmed

Hughes²

2022

Beni-Suef Univ J Basic Appl Sci

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Background Since the outbreak of the COVID-19 virus, ethnomedicinal plants have been used in diverse geographical locations for their purported prophylactic and pharmacological effects. Medicinal plants have been relied on by people around the globe for centuries, as 80% of the world’s population rely on herbal medicines for some aspect of their primary health care needs, according to the World Health Organization. Main body This review portrays advances in traditional phytomedicine by bridging the knowledge of ethno-phytomedicine and COVID-19 healthcare. Ethnomedicinal plants have been used for symptoms related to COVID-19 as antiviral, anti-infective, anti-inflammatory, anti-oxidant, antipyretic, and lung–gut immune boosters. Traditionally used medicinal plants have the ability to inhibit virus entry and viral assembly, bind to spike proteins, membrane proteins, and block viral replications and enzymes. The efficacy of traditional medicinal plants in the terms of COVID-19 management can be evaluated by in vitro, in vivo as well as different in silico techniques (molecular docking, molecular dynamics simulations, machine learning, etc.) which have been applied extensively to the quest and design of effective biotherapeutics rapidly. Other advances in traditional phytomedicines against COVID-19 are controlled clinical trials, and notably the roles in the gut microbiome. Targeting the gut microbiome via medicinal plants as prebiotics is also found to be an alternative and potential strategy in the search for a COVID-19 combat strategy. Conclusions Since medicinal plants are the sources of modern biotherapeutics development, it is essential to build collaborations among ethnobotanists, scientists, and technologists toward developing the most efficient and the safest adjuvant therapeutics against the pandemic of the twenty-first century, COVID-19.

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“…The essential oils also possess bioactive compounds, such as terpenoids, phenylpropanoids and alkaloids, responsible for biological activities. The ability of these oil nanocarrier systems has proved the potential antiviral activity [ 162 ]. Therefore, nanoparticles have been developed as carriers to transfer the specific biomolecules to their specific target sites [ 163 ].…”

Section: Antimicrobial Properties Of Chinese Herbsmentioning

confidence: 99%

Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology

2021

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Recent advances in nanotechnology have opened up new avenues for the controlled synthesis of nanoparticles for biomedical and pharmaceutical applications. Chinese herbal medicine is a natural gift to humanity, and it has long been used as an antibacterial and anticancer agent. This study will highlight recent developments in the phytonanotechnological synthesis of Chinese herbal medicines to utilize their bioactive components in biomedical and therapeutic applications. Biologically synthesized silver nanoparticles (AgNPs) have emerged as a promising alternative to chemical and physical approaches for various biomedical applications. The comprehensive rationale of combinational or synergistic effects of Chinese herb-based AgNPs synthesis was investigated with superior physicochemical and biological properties, and their biomedical applications, including antimicrobial and anticancer activity and wound healing properties. AgNPs can damage the cell ultrastructure by triggering apoptosis, which includes the formation of reactive oxygen species (ROS), DNA disintegration, protein inactivation, and the regulation of various signaling pathways. However, the anticancer mechanism of Chinese herbal medicine-based AgNPs is more complicated due to the potential toxicity of AgNPs. Further in-depth studies are required to address Chinese herbs’ various bioactive components and AgNPs as a synergistic approach to combat antimicrobial resistance, therapeutic efficiency of drug delivery, and control and prevention of newly emerged diseases.

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Antiviral Essential Oils Incorporated in Nanocarriers: Strategy for Prevention from COVID-19 and Future Infectious Pandemics

Cited by 21 publications

References 0 publications

Recent Advances on Nanomaterials to COVID‐19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS‐CoV‐2 Inhibition/Inactivation

Recent Advances on Nanomaterials to COVID‐19 Management: A Systematic Review on Antiviral/Virucidal Agents and Mechanisms of SARS‐CoV‐2 Inhibition/Inactivation

Role of ethno-phytomedicine knowledge in healthcare of COVID-19: advances in traditional phytomedicine perspective

Biomedical Applications of Chinese Herb-Synthesized Silver Nanoparticles by Phytonanotechnology

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