Antiviral properties of silver nanoparticles against norovirus surrogates and their efficacy in coated polyhydroxyalkanoates systems

Castro-Mayorga, J.L.; Randazzo, Walter; Fabra, María José; Lagarón, José M.; Aznar, Rosa; Sánchez, Glòria

doi:10.1016/j.lwt.2017.01.065

Cited by 93 publications

(86 citation statements)

References 21 publications

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“…In line, micrometer-sized magnetic hybrid colloid activated with AgNPs reduced the infectivity of murine norovirus, which is another norovirus surrogate, by more than 2 log, while more than a 6 log reduction was reported for E. coli [50,51]. Similarly, AgNP-containing fiber mats reduced MNV (novel mouse norovirus) infectivity by only 0.86 log while under the same conditions, and no viable counts of Salmonella enterica and Listeria monocytogenes were recorded [52].…”

Section: Antiviral Activity Against Norovirus Surrogatementioning

confidence: 66%

Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

et al. 2020

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An antimicrobial polymeric bilayer structure based on the application of an acrylic coating containing hollow zinc oxide nanotubes over a polymeric substrate was developed in this work. Firstly, zinc oxide nanotubes (ZnO NT ) were obtained by an atomic layer deposition (ALD) process over electrospun polyvinyl alcohol nanofibers followed by polymer removal through calcination with the purpose of obtaining antimicrobial nanostructures with a high specific area. Parameters of electrospinning, ALD, and calcination processes were set in order to obtain successfully hollow zinc oxide nanotubes. Morphological studies through scanning electron microscopy (SEM) and transmission electron microscopy (TEM) microscopies confirmed the morphological structure of ZnO NT with an average diameter of 180 nm and thickness of approximately 60 nm. Thermal and X-ray diffraction (XRD) analyses provided evidence that calcination completely removed the polymer, resulting in a crystalline hexagonal wurtzite structure. Subsequently, ZnO NT were incorporated into a polymeric coating over a polyethylene extruded film at two concentrations: 0.5 and 1 wt. % with respect to the polymer weight. An antimicrobial analysis of developed antimicrobial materials was performed following JIS Z2801 against Staphylococcus aureus and Escherichia coli. When compared to active materials containing commercial ZnO nanoparticles, materials containing ZnO NT presented higher microbial inhibition principally against Gram-negative bacteria, whose reduction was total for films containing 1 wt. % ZnO NT . Antiviral studies were also performed, but these materials did not present significant viral reduction.Nanomaterials 2020, 10, 503 2 of 14 antimicrobial nanostructures are one of the most promising alternatives in the search for new antimicrobial substances [3][4][5]. The attention has been principally centered on metallic/metal oxide nanoparticles due to their broad antibacterial and antifungal activities at low concentrations thanks to their high specific area [6][7][8][9].Zinc oxide (ZnO) nanoparticles are an inorganic material with optical, chemical sensing, electric conductivity, catalytic, photochemical, and antimicrobial properties. This metal oxide presents three crystal structures: wurtzite, zinc blend, and rocksalt, with a direct wide band gap of 3.3 Ev [10]. Some works have evidenced ZnO nanoparticles with dimensions smaller than 100 nm have shown increasing antimicrobial properties against Gram-negative and Gram-positive bacteria due to a higher cellular internalization. Specifically, Verma et al. (2018) studies have indicated that the antibacterial activity of ZnO nanoparticles against Staphylococcus aureus and Escherichia coli increased with the decrease in their size from 250 to 80, 40, and 20 nm due to an increased reactive oxygen species generation and membrane damage in bacteria [11,12]. Different synthesis methods as sol-gel, hydrothermal, simple thermal sublimation, vapor-liquid-solid, double-jet precipitation, self-combustion, and "green synthes...

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Section: Antiviral Activity Against Norovirus Surrogatementioning

confidence: 66%

Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

et al. 2020

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“…Nonenveloped virus is more stable than enveloped virus, the latter being surrounded by an outer lipid membrane. [ 176,177 ] The antiviral activity of Ag nanoparticles (98%) toward HIV‐1 is more than Au nanoparticles (from 6% to 20%).…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

518

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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“…To overcome this lack, standard protocols developed for bacteria are often modified and adjusted to the purposes and circumstances of the antiviral assessment (Figure ). In fact, the antiviral experimental trials commonly apply well‐established procedures aimed to assess the antimicrobial activity on plastics, and other nonporous surfaces, against bacteria and molds, such as the ISO 22196:2011 and the Japanese Industrial Standard JIS Z 2801:2000 (Castro‐Mayorga et al., ; Fabra et al., ; Martínez‐Abad, Ocio, Lagarón, & Sánchez, ). Other protocols have been also applied that differ in the inoculation, exposure, and recovery techniques adopted.…”

Section: Methodologies Applied To Assess the Antiviral Activity Of Pomentioning

confidence: 99%

“…Although in the following sections specific examples about the strategies followed for the development of different types of antiviral materials are given, a general trend in this area is related to taking advantage of the inherent characteristics of different biopolymers to foster their interactions with the active compounds to control the release properties (Mascheroni, Capretti, Limbo, & Piergiovanni, ; Tawakkal, Cran, & Bigger, ). Processing methods have also been adapted to improve biocidal activity making use of nanotechnology tools, either to protect the bioactive compounds, through micro‐ or nanoencapsulation (Gómez‐Mascaraque, Sánchez, & Lopez‐Rubio, ), or to develop multilayered/nanolaminate delivery systems with improved performance (Aloui & Khwaldia, ; Castro‐Mayorga et al., ). In the specific case of edible coatings for fresh food products, nanoemulsions are being implemented, as they can be formulated with natural food‐grade ingredients and their production process is easily scalable in the industry by high‐pressure homogenization process (Donsì, Annunziata, Sessa, & Ferrari, ).…”

Section: Polymers and Biopolymers As Carriers Of Active Compoundsmentioning

confidence: 99%

“…Since it is of particular interest to develop active surfaces with enhanced virucidal activity at lower loadings due to legislative restrictions, Castro‐Mayorga et al. () have recently developed novel routes to guarantee the dispersion and stability of silver nanoparticles (AgNPs) in biopolymer matrices. Furthermore, the effect that the stabilized AgNPs had on transparency and mechanical properties was negligible due to the low AgNPs loadings.…”

Section: Development Of Food‐grade Polymers and Biopolymers With Antimentioning

confidence: 99%

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Polymers and Biopolymers with Antiviral Activity: Potential Applications for Improving Food Safety

Randazzo

Fabra

Falcó

et al. 2018

Comp Rev Food Sci Food Safe

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Gastroenteritis and hepatitis, caused by human noroviruses (HuNoVs) and hepatitis A virus (HAV), respectively, are the most common illnesses resulting from the consumption of food contaminated with human enteric viruses. Food-grade polymers can be tailor designed to improve food safety, either as novel food-packaging materials imparting active antimicrobial properties, applied in food contact surfaces to avoid cross-contamination, or as edible coatings to increase fresh produce's shelf life. The incorporation of antimicrobial agents into food-grade polymers can be used to control the food microbiota and even target specific foodborne pathogens to improve microbiological food safety and to enhance food quality. Enteric viruses are responsible for one fifth of acute gastroenteritis cases worldwide and the development of food-grade polymers and biopolymers with antiviral activity for food applications is a topic of increased interest, both for academia and the food industry, even though developments are still limited. This review compiles existing studies in this widely unexplored area and highlights the potential of these developments to improve viral food safety.

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Antiviral properties of silver nanoparticles against norovirus surrogates and their efficacy in coated polyhydroxyalkanoates systems

Cited by 93 publications

References 21 publications

Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

Antimicrobial Bilayer Nanocomposites Based on the Incorporation of As-Synthetized Hollow Zinc Oxide Nanotubes

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Polymers and Biopolymers with Antiviral Activity: Potential Applications for Improving Food Safety

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