Antivirulence and wound healing effects of royal jelly and garlic extract for the control of MRSA skin infections

El-Gayar, Mona H.; Aboshanab, Khaled M.; Aboulwafa, Mohammad M.; Hassouna, Nadia A.

doi:10.1016/j.wndm.2016.05.004

Cited by 20 publications

(20 citation statements)

References 23 publications

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“…RJ is also an important functional substance that has been widely used in commercial products, dietary supplements, and cosmetics [2]. RJ has been shown to possess versatile bioactive properties such as antibacterial [3], immunomodulatory [4], antiviral [5], wound-healing [6], growth promoting [7], antioxidant [8], nephroprotective [9], and anti-inflammatory [10] activities. Fresh RJ consists of water (50–60%), lipids (3–8%), proteins (18%), carbohydrates (7–18%), and other trace elements [11].…”

Section: Introductionmentioning

confidence: 99%

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Chen

Wang

Zhang

et al. 2016

Mediators of Inflammation

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Trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (SEA) are the three major fatty acids in royal jelly (RJ). Previous studies have revealed several pharmacological activities of 10-H2DA and 10-HDAA, although the anti-inflammatory effects and underlying mechanisms by which SEA acts are poorly understood. In the present study, we evaluated and compared the in vitro anti-inflammatory effects of these RJ fatty acids in lipopolysaccharide-stimulated RAW 264.7 macrophages. The results showed that 10-H2DA, 10-HDAA, and SEA had potent, dose-dependent inhibitory effects on the release of the major inflammatory-mediators, nitric oxide, and interleukin-10, and only SEA decreased TNF-α production. Several key inflammatory genes have also been modulated by these RJ fatty acids, with 10-H2DA showing distinct modulating effects as compared to the other two FAs. Furthermore, we found that these three FAs regulated several proteins involved in MAPK and NF-κB signaling pathways. Taken together, these findings provide additional references for using RJ against inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

Chen

Wang

Zhang

et al. 2016

Mediators of Inflammation

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“…Wound healing is an important health issue and a wide range of in vivo and in vitro studies indicate that RJ seems play a significant role [125,126]. The development of atopic dermatitis-like skin lesions in picryl chloride treated NC/Nga mouse is suppressed after treatment with RJ.…”

Section: Wound Healing Activitymentioning

confidence: 99%

“…Furthermore, this method creates vasodilation effects around the wound which could dilate blood vessels to increase blood flow and prevent the wound from infection by other microbial organisms [129]. In addition, RJ promotes the wound healing response to control dermal infection induced by methicillin-resistant S. aureus (MRSA) [126]. Water-soluble proteins of RJ and its fractions induce proliferative and migratory effects on a human epidermal keratinocyte in a scratch wound model.…”

Section: Wound Healing Activitymentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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“…It was found that RJ has anti-inflammatory and cell regeneration effect in the colon of rats with acetic acid induced colitis (Karaca et al, 2012). El-Gayar et al (2016) reported that RJ could eradicate hospital acquired infections due to Methicillin resistant S. aureus (MRSA) and promote wound healing.…”

Section: Antibiotic Effectmentioning

confidence: 99%

Royal Jelly: Chemistry, Storage and Bioactivities

Maghsoudlou

Mahoonak

Mohebodini

et al. 2019

Journal of Apicultural Science

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Royal jelly (RJ) has been known for centuries, but in the last 5-6 decades its systematic production and consumption has increased. RJ is secreted by the hypopharyngeal and mandibular glands of worker honeybees (Apis mellifera). This thick and milky substance contains water, proteins, carbohydrates, lipids, minerals, vitamins and such bio-active compounds as acetylcholine, peptides, the hormones testosterone, progesterone, prolactin, estradiol, (hydroxydecanoic acid) (HAD), adenosine monophosphate (AMP)-N1Oxide, polyphenols, flavonoids and adenosine. Because of its bioactive compounds, RJ can be considered as a functional and nutraceutical food. The main goal of this review is to summarize and update its physicochemical properties, bio-active ingredients, storage stability and shelf life. The functional properties are antioxidative activity, insulin-like action, improvement against diabetes, liver protection, antitumoral action, neurotrophic action, antibiotic effect, anti-inflammatory action and wound healing, hypotensive effect and blood regulatory actions, anti-aging effect and skin protection, effects on the reproductive system and fertility and also fortifying, tonic action and immunomodulating and anti-alergic activity. RJ may cause allergic reactions, asthma and even fatal anaphylaxis in some humans. Therefore, RJ should be orally ingested as nutreaceutical agent or food-ingredient only after an allergy test.

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Antivirulence and wound healing effects of royal jelly and garlic extract for the control of MRSA skin infections

Cited by 20 publications

References 23 publications

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

In VitroAnti-Inflammatory Effects of Three Fatty Acids from Royal Jelly

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Royal Jelly: Chemistry, Storage and Bioactivities

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