2009
DOI: 10.1016/j.jdermsci.2008.08.007
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Antiwrinkle effect of adipose-derived stem cell: Activation of dermal fibroblast by secretory factors

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Cited by 254 publications
(184 citation statements)
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References 27 publications
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“…The activity of the mTOR signaling pathway can be modulated by a variety of factors and pathways acting on different steps, and mTORC1 was activated by the binding of IGF1 to its receptor (40,43). After transplantation, ASCs remained viable at the injured site and secreted growth factors in a continuous and regulated manner in response to the environmental cues, including IGF (2,5,9,14,(22)(23)(24)37,44,46). We thus concluded that the increased muscle size, wet weight, and area of the myofibers in the ASC-transplanted groups are due to the following mechanism: The transplanted ASCs secrete growth factors; those stimulate the mTOR signaling pathway, which activates the synthesis of protein and muscle hypertrophy.…”
Section: Discussionmentioning
confidence: 99%
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“…The activity of the mTOR signaling pathway can be modulated by a variety of factors and pathways acting on different steps, and mTORC1 was activated by the binding of IGF1 to its receptor (40,43). After transplantation, ASCs remained viable at the injured site and secreted growth factors in a continuous and regulated manner in response to the environmental cues, including IGF (2,5,9,14,(22)(23)(24)37,44,46). We thus concluded that the increased muscle size, wet weight, and area of the myofibers in the ASC-transplanted groups are due to the following mechanism: The transplanted ASCs secrete growth factors; those stimulate the mTOR signaling pathway, which activates the synthesis of protein and muscle hypertrophy.…”
Section: Discussionmentioning
confidence: 99%
“…3E, F). ASCs remained viable after transplantation and secreted a variety of growth factors and cytokines, which activated the differentiation of satellite cells to myoblasts and from myoblasts to myotubes at the injured site (2,5,9,14,(22)(23)(24)37,44,46). The myogenic effect of these growth factors and cytokines might increase the number of myogenin-expressing myocytes.…”
Section: Discussionmentioning
confidence: 99%
“…MSC-conditioned media has also been seen to contain these anti-oxidative factors including G-CSF, GM-CSF and IL-12, as reviewed by Kim et al (140). In addition, evidence has supported that MSC and its conditioned media respectively decrease oxidative damage in culture when fibroblast cells are exposed to oxidative damage-inducing environments such as UVB (141) or tert-butyl hydroperoxide (tbOOH) (142). In addition, research indicates that MSC posses not only considerable ability to support oxidative stress by producing anti-oxidative mediators, but may actually be stimulated by hipoxia-induced ROS (reactive oxigen species).…”
Section: Anti-oxidative Factorsmentioning
confidence: 99%
“…Moreover the effect of the ASCs in reducing the UVBinduced wrinkles was positive and the anti-wrinkle effects of the ASCs is proven by increasing the collagen production by human dermal fibroblasts (33). Generally the ASCs have great potential for applications in repair of skin scars, rejuvenation of aging skin and aging-related skin lesions (34).…”
Section: Isolation and Clinical Application Of Adipose-derived Stems mentioning
confidence: 99%