Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells

4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

“…At low concentrations (1-20 μM), AQ from ethanolic extract of A. cinnamomea mycelia showed hepatoprotective effects from ethanol-induced oxidative stress through heme oxygenase-1and Nrf-2 signaling activation (Kumar et al, 2011). On the other hand, high concentrations of AQ (30 μM) induce a cross-talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells (Yu et al, 2012). A recent study also showed that 4-AAQB arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels (Lin and Chiang, 2011).…”

Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions

“…ANQ inhibits lipopolysaccharide-elicited inducible nitric oxide synthase (iNOS) expression and NO production in murine macrophages, and suppresses renal inflammation through Nrf2 activation and reactive oxygen species reduction (Yang et al, 2013b). In addition, ANQ induces apoptosis and autophagy in pancreatic cancer cells through inhibiting PI3K/AKT/mTOR signaling cascade (Yu et al, 2012), and suppresses the growth of hepatoma and lung cancer cells by modulating the PI3K/mTOR activation (Chiang et al, 2010;Kumar et al, 2011). These data suggest that PI3K/AKT may be the target of ANQ.…”

“…ANQ was reported to have antitumor effects in hepatomas, pancreatic cancer, and lung cancer. Previous studies revealed that ANQ induces apoptosis and autophagy in pancreatic cancer cells (Yu et al, 2012), and modulates AMPK or PI3K/mammalian target of rapamycin (mTOR) signaling in hepatomas and lung cancer, leading to inhibited cell proliferation (Chiang et al, 2010;Kumar et al, 2011). However, the effect of ANQ on breast cancer is still unknown.…”

Anticancer Effect of Phellinus linteus; Potential Clinical Application in Treating Pancreatic Ductal Adenocarcinoma

“…Yu et al [44] demonstrated that antroquinonol, a ubiquinone derivative isolated from a camphor tree mushroom, Antrodiacamphorata, induced a concentration-dependent inhibition of cell proliferation in pancreatic cancer PANC-1 and AsPC-1 cells. This anticancer activity in human pancreatic cancers was found to be through an inhibitory effect on PI3-kinase/Akt/mTOR pathways, which results in down-regulation of cell cycle regulators.…”