“…39,40 Anxiety and depression, common psychiatric disorder, influenced patients' quality of life and contributed to emotional upset, social relationship, and poor compliance. [41][42][43][44] It was believed that social support, as a buffer system against depression, may indirectly improve fatigue. 45 As one of the primary caregivers and givers of social support for MHD patients, family members offer love and approval to the patients.…”