Anxiety and depression in patients with head and neck cancer: 6-month follow-up study

Wu, Yaopan; Lin, Pao‐Yen; Chien, Chih‐Yen; Fang, Fu‐Min; Chiu, Nan-Tsing; Hung, Chi‐Fa; Liu, Yu; Chong, Mian‐Yoon

doi:10.2147/ndt.s103203

Cited by 98 publications

(108 citation statements)

References 28 publications

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Section: Discussionsupporting

confidence: 90%

“…This finding extends previous studies with HNC patients which have demonstrated that difficulty with social contact is a risk factor for poor mental health outcomes in patients (Psoter, Aguilar, Levy, Baek, & Morse, 2012; Wu et al, 2016). Taken together, findings in this study and others (Psoter et al, 2012; Wu et al, 2016) suggest that patients’ difficulties with social contact may contribute to both patient and caregiver mental health. In accordance with other caregiver studies (Chang, Chiou, & Chen, 2010; Grunfeld et al, 2004; Rhee et al, 2008), caregiving burden (included in the appraisal domain) was significantly related to caregiver’s mental health functioning, depression, and anxiety.…”

Section: Discussionsupporting

confidence: 90%

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Contextual and stress process factors associated with head and neck cancer caregivers’ physical and psychological well-being

et al. 2018

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Head and neck cancer (HNC) caregivers are especially vulnerable to poor outcomes because the HNC patients are at high risk for physical and functional impairments. This study examines contextual and stress process variables potentially associated with HNC caregivers' physical and psychological well-being. Patient-caregiver variables included socio-demographics, primary stressors (caregiving, patient clinical characteristics, HNC-related symptoms/dysfunction), secondary stressors (caregiver employment, childcare responsibilities and sleep duration <7 hr), appraisal, and response (physical activity). General linear models modeled caregiver well-being, along with depression and anxiety. A total of 33 patient-caregiver dyads were included. Most caregivers were female (81.8%) and patient spouses/partners (72.7%). Factors significantly associated with better caregiver physical well-being included caregiver older age, <2 comorbidities, ≥7 hr of sleep, ≥3 days/week physical activity, and patient swallowing and speech dysfunction. Factors significantly associated with better caregiver mental health functioning were less patient social dysfunction and less perceived caregiving burden. Short nighttime sleep, higher caregiver burden, and <3 days/week physical activity were also significantly related to caregivers' depression and anxiety. Results suggested caregiver behaviors and perceived burden, along with patient HNC concerns are linked with caregiver well-being. These behavioral, cognitive, and patient factors should be incorporated into caregiver screening tools or targeted with behavioral interventions to improve caregiver well-being.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Contextual and stress process factors associated with head and neck cancer caregivers’ physical and psychological well-being

et al. 2018

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“…In total 33 of these articles fulfilled the eligibility criteria. In addition, two studies were included after screening the reference lists, resulting in 35 articles . These 35 articles provided results on 27 separate studies.…”

Section: Resultsmentioning

confidence: 99%

“…In Table , the characteristics of the 35 included studies are described. Twenty‐one studies reported on factors associated with depression at a single time point, 10 studies on factors associated with the course of depression and four on both . Results on factors associated with depression at a single time point and the course of depression are presented separately.…”

Section: Resultsmentioning

confidence: 99%

Factors associated with depression over time in head and neck cancer patients: A systematic review

et al. 2019

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Objective To systematically review the literature on factors associated with a clinical diagnosis of depression or symptoms of depression (depression) among head and neck cancer (HNC) patients. Methods The search was conducted in PubMed, PsycINFO, and CINAHL. Studies were included if they investigated factors associated with depression among HNC patients, they were of prospective or longitudinal nature, and English full text was available. The search, data extraction, and quality assessment were performed by two authors. Based on the data extraction and quality assessment, the level of evidence was determined. Results In total, 35 studies were included: 21 on factors associated with depression at a single (later) time point, 10 on the course of depression, and four on both. In total, 77 sociodemographic, lifestyle, clinical, patient‐reported outcome measures, and inflammatory factors were extracted. Regarding depression at a single time point, there was strong evidence that depression at an earlier time point was significantly associated. For all other factors, evidence was inconclusive, although evidence suggests that age, marital status, education, ethnicity, hospital/region, sleep, smoking, alcohol, surgery, treatment, tumor location, and recurrence are not important associated factors. Regarding the course of depression, we found inconclusive evidence for all factors, although evidence suggests that gender, age, chemotherapy, pain, disease stage, treatment, and tumor location are not important associated factors. Conclusion Depression at an earlier time point is significantly associated with depression later on. Several sociodemographic and clinical factors seem not to be important factors associated with depression. For other factors, further research is warranted.

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“…While caring for cancer patients, we must pay attention to early detection of and intervention for psychological distress. For HNC patients, who may have problems stemming from the withdrawal syndrome, physical disfigurement, side effects from treatment, or disease progression and challenges with social contacts, the prevalence of depressive symptoms has always been reported among the highest rates within the entire cancer population [2, 19]. …”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia and statins use for the risk of new-onset anxiety/depression in patients with head and neck cancer: A population-based study

et al. 2017

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ObjectiveAnxiety/depression is common among patients with head and neck cancer (HNC), and can negatively affect treatment compliance and outcome. The aim of this study was to assess the association between hyperlipidemia and the risk of new-onset anxiety/depression after the diagnosis of HNC and the influence of administering statins.MethodsA matched longitudinal cohort study of 1632 subjects (408 HNC patients with preexisting hyperlipidemia and 1224 age- and sex-matched HNC patients without hyperlipidemia) was included and analyzed by using data from Taiwan’s National Health Insurance Research Database from January 1996 to December 2012. The incidence and hazard ratios (HRs) for the development of new-onset anxiety/depression were examined between the two groups. Cox proportional hazard regression was applied to estimate the relative risks of anxiety/depressive disorders adjusted for potential confounding factors. To estimate the risks of anxiety/depression in different sub-groups, a stratified analysis was also used.ResultsHNC patients with preexisting hyperlipidemia had a higher risk for comorbidities such as hypertension, diabetes mellitus, and cardiovascular disease (P <0.001). The incidence rate of anxiety/depression in the HNC patients with preexisting hyperlipidemia was also significantly higher than that among patients without hyperlipidemia (10.78% vs 7.27%, respectively; P = 0.03). A Cox regression model revealed that preexisting hyperlipidemia was an independent risk factor for anxiety/depression (aHR, 1.96; 95% CI, 1.30–2.94). Statins use was protective against anxiety/depression among HNC patients with hyperlipidemia (aHR, 0.85; 95% CI, 0.46–1.57), especially for individuals older than 65 years and for females.ConclusionsPreexisting hyperlipidemia was associated with increased risk of new-onset anxiety/depression in the HNC patients. Statins use for HNC patients with hyperlipidemia could decrease the risk of anxiety/depression, especially for those older than 65 years and for female patients.

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Anxiety and depression in patients with head and neck cancer: 6-month follow-up study

Cited by 98 publications

References 28 publications

Contextual and stress process factors associated with head and neck cancer caregivers’ physical and psychological well-being

Contextual and stress process factors associated with head and neck cancer caregivers’ physical and psychological well-being

Factors associated with depression over time in head and neck cancer patients: A systematic review

Hyperlipidemia and statins use for the risk of new-onset anxiety/depression in patients with head and neck cancer: A population-based study

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