Hyperlipidemia and statins use for the risk of new-onset anxiety/depression in patients with head and neck cancer: A population-based study

Huang, Chung‐I; Lin, Li‐Ching; Tien, Hung-Cheng; Que, Jenny; Ting, Wei; Chen, Po-Chun; Wu, Hsin-Min; Ho, Chung‐Han; Wang, Jhi‐Joung; Ren-Hong, Wang; Yang, Ching‐Chieh

doi:10.1371/journal.pone.0174574

Cited by 13 publications

(13 citation statements)

References 32 publications

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“…Women in both the hysterectomy case group and the comparison group were followed up until hyperlipidemia identified, death, withdrawal from the NHI program, or the end of 2013 11 .…”

Section: Methodsmentioning

confidence: 99%

Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan

Tsai

Hsu

et al. 2018

Sci Rep

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Hysterectomy has been associated with metabolic change and cardiovascular risk for women after removing the uterus, but inconclusive. This large retrospective cohort study evaluated the hyperlipidemia risk for women with a hysterectomy and/or oophorectomy. From claims data of one million people in the National Health Insurance (NHI) database of Taiwan, we established a cohort consisting of 5887 women newly received a surgery of hysterectomy from 2000–2013, 563 women had a hysterectomy and a oophorectomy, and 556 women had a oophorectomy. From the claims data, 28024 women without any of the surgeries were identified to form the comparison cohort, frequency matched by birth year and surgery year of the women with hysterectomy. By the end of 2013, the incidence of hyperlipidemia was 1.3 times greater in women with a hysterectomy than in comparison women (3.43 vs. 2.65 per 100 person-years), with an adjusted hazard ratio (aHR) of 1.27 (95% CI = 1.19–1.35) for hysterectomy women after controlling for age, oophorectomy, hormone therapy and comorbidities. The incidence of hyperlipidemia increased to 4.93 per 100 person-years in women with both a hysterectomy and an oophorectomy. The relative risk of hyperlipidemia was higher for young women than the elderly women with the surgery. Women with comorbidity of obesity, hypertension or diabetes had a higher incidence of hyperlipidemia. In conclusion, the risk of developing hyperlipidemia could be elevated for women who had a hysterectomy and/or an oophorectomy. Women with hysterectomy should routinely monitor their metabolic status, particularly for young women and those with comorbidity of metabolic symptoms.

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“…Women in both the hysterectomy case group and the comparison group were followed up until hyperlipidemia identified, death, withdrawal from the NHI program, or the end of 2013 11 .…”

Section: Methodsmentioning

confidence: 99%

Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan

Tsai

Hsu

et al. 2018

Sci Rep

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“…Hyperlipidemia is closely related to stress and anxiety 42 . Sympathetic activation in generalized anxiety disorder increases lipoprotein lipase activity through the release of adrenaline and corticosteroids 14 .…”

Section: Discussionmentioning

confidence: 99%

Anxiety disturbs the blood plasma metabolome in acute coronary syndrome patients

Jiang

et al. 2021

Sci Rep

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Coronary heart disease (CHD) is the result of a complex metabolic disorder caused by various environmental and genetic factors, and often has anxiety as a comorbidity. Rupture of atherosclerotic plaque in CHD patients can lead to acute coronary syndrome (ACS). Anxiety is a known independent risk factor for the adverse cardiovascular events and mortality in ACS, but it remains unclear how stress-induced anxiety behavior impacts their blood plasma metabolome and contributes to worsening of CHD. The present study aimed to determine the effect of anxiety on the plasma metabolome in ACS patients. After receiving ethical approval 26 ACS patients comorbid anxiety were recruited and matched 26 ACS patients. Blood plasma samples were collected from the patients and stored at − 80 °C until metabolome profiling. Metabolome analysis was performed by liquid chromatography mass spectrometry (LC–MS), and the data were subjected to multivariate analysis. Disturbance of 39 plasma metabolites was noted in the ACS with comorbid anxiety group compared to the ACS group. These disturbed metabolites were mainly involved in tryptophan metabolism, pyrimidine metabolism, glycerophospholipid metabolism, pentose phosphate pathway, and pentose and glucuronate interconversions. The most significantly affected pathway was tryptophan metabolism including the down-regulation of tryptophan and serotonin. Glycerophospholipids metabolism, pentose and glucuronate interconversions, and pentose phosphate pathway were also greatly affected. These results suggest that anxiety can disturb three translation of material in ACS patients. Besides the above metabolism pathways pyrimidine metabolism was significantly disturbed. Based on the present findings the plasma metabolites monitoring can be recommended and may be conducive to early biomarkers detection for personalized treatment anxiety in CHD patients in future.

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“…Hyperlipidemia is closely related to stress and anxiety 28 . Sympathetic activation in generalized anxiety disorder increases lipoprotein lipase activity through the release of adrenaline and corticosteroids 11 .…”

Section: Discussionmentioning

confidence: 99%

Anxiety Disturbs Metabolome of Blood Plasma in Coronary Heart Disease Patients

Hong-yan

Jiang

et al. 2021

Preprint

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Coronary heart disease (CHD) is the result of complex metabolic disorder caused by various environmental and genetic factors, and often comorbidity with anxiety. Anxiety was known to an independent risk factor for the adverse cardiovascular events and mortality in patients with CHD, while how stress-induced anxiety behavior impacts the metabolome of blood plasma in CHD patients and contributes to CHD worse is unclear. So this study aimed to investigate the effect of anxiety on metabolome of plasma in CHD patients. According to the inclusion and exclusion standard the blood plasma of CHD patients and CHD comorbidity with anxiety were collected after ethics approval. Metabolome analysis of blood plasma using liquid chromatography mass spectrometry (LC/MS) was performed, then multivariate data analysis was applied to evaluate the data. Disturbance of 39 plasma metabolites were altered in CHD patients accompany by anxiety patients as compared to control group. These disturbed metabolites were mainly involved in tryptophan metabolism, pyrimidine metabolism, glycerophospholipid metabolism, pentose phosphate metabolism, phenylalanine metabolism, pentose and glucuronate interconversions. The most significant pathway was tryptophan metabolism including the down-regulation of tryptophan and serotonin. In addition to tryptophan metabolism, the glycerophospholipids metabolism, pentose and glucuronate interconversions and pentose phosphate pathway were also greatly affected in this study. These results suggest that anxiety may further disturb CHD three translation of material metabolome. Besides theses metabolism pathway pyrimidine metabolism disturbed significantly which can aggravate the disease in patients with CHD. From these resoults the plasma metabolites monitoring was suggested to be recommended and may be conducive to early detect biomarkers to personalized treatment anxiety in patients with CHD in future.

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Hyperlipidemia and statins use for the risk of new-onset anxiety/depression in patients with head and neck cancer: A population-based study

Cited by 13 publications

References 32 publications

Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan

Risk of Hyperlipidemia in Women with Hysterectomy-A Retrospective Cohort Study in Taiwan

Anxiety disturbs the blood plasma metabolome in acute coronary syndrome patients

Anxiety Disturbs Metabolome of Blood Plasma in Coronary Heart Disease Patients

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