Anxiety and depression severity are related to right but not left onset Parkinson's disease duration

Foster, Paul S.; Drago, Valeria; Crucian, Gregory P.; Sullivan, William K.; Rhodes, Robert D.; Shenal, Brian V.; Skoblar, Barry M.; Skidmore, Frank; Heilman, Kenneth M.

doi:10.1016/j.jns.2011.02.023

Cited by 29 publications

(26 citation statements)

References 57 publications

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“…Foster et al. (2011) reported that duration of illness was positively associated with severity of anxiety and depressive symptoms in ROPD. However, in our study, greater anxiety was seen in LOPD, and duration as a dependent variable failed to reveal any significant covariance with any measure including DASS anxiety.…”

Section: Discussionmentioning

confidence: 99%

“…Those with ROPD show a deficit in mental rotation related to one's self‐view (Bowen, Burns, Brady, & Yahr, 1976; Cronin‐Golomb, 2010). In the clinical domain, those with ROPD have shown differences such as greater apathy (Bogdanova & Cronin‐Golomb, 2012), more severe psychosis (Cubo, 2010), and longer duration of illness associated with greater anxiety and depressive symptoms (Foster et al., 2011). …”

Section: Introductionmentioning

confidence: 99%

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Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

et al. 2016

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BackgroundParkinson's disease (PD) usually emerges with a unilateral side‐of‐onset (left‐onset: LOPD; right‐onset: ROPD; Marinus & van Hilten, 2015) due to an asymmetrical degeneration of striatal dopaminergic neurons (Donnemiller et al., Brain, 135, 2012, 3348). This has led to a body of research exploring the cognitive, neuropsychological, and clinical differences between LOPD and ROPD (e.g., Verreyt et al., Neuropsychology Review, 21, 2011, 405).MethodsThirty ROPD and 14 LOPD cases were drawn from a Boston clinic specializing in PD. Various cognitive and neuropsychological measures were used in an attempt to discover if there were indeed any differences between LOPD and ROPD in this cohort.ResultsFor LOPD, duration of illness was found to be significantly greater than that of ROPD. However, further testing was able to confirm that despite this difference, it was not the cause of the other significant differences found. Furthermore, this increased duration was consistent with a previous study (Munhoz et al., Parkinsonism and Related Disorders, 19, 2013, 77). Performance on the Digit Span Backward (DSB) was found to be significantly poorer in LOPD than ROPD, suggesting compromised executive function in LOPD. Additionally, LOPD had significantly greater anxiety on the DASS Anxiety scales than ROPD. However, unlike Foster et al (Cognitive and Behavioral Neurology, 23, 2010, 4), this increased anxiety could not account for the poorer performance on the DSB for LOPD. Finally, ROPD had significantly greater magical ideation than LOPD, which can be explained by the theory put forth by Brugger and Graves (European Archives of Psychiatry, 247, 1997, 55).ConclusionClear and significant differences between LOPD and ROPD were found within our cohort. LOPD showed greater impairment of working memory, greater anxiety, and greater duration of illness—all independent of one another; whereas, those with ROPD had greater magical ideation, also independent of any other variables.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

et al. 2016

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“…Empirical findings principally involve cognition: the side of motor onset does not influence cognition in newly diagnosed untreated patients (Erro et al, 2013; Poletti et al, 2013); in patients “on” dopaminergic therapy a right-side motor symptom predominance is typically associated with difficulties in tasks of language and verbal memory, whereas a left-side motor symptom predominance is typically associated with difficulties in visuospatial tasks (Verreyt et al, 2011). More heterogeneous and controversial are findings on the role of the side of motor onset on motor subtypes (e.g., Stewart et al, 2009; Baumann et al, 2013) and especially on psychopathological subtypes (e.g., Foster et al, 2011; Dewey et al, 2012), therefore more empirical studies are needed on this issue.…”

Section: Discussion: Relationships Among Pd Subtypesmentioning

confidence: 99%

Neural and behavioral substrates of subtypes of Parkinson’s disease

Moustafa

Poletti

2013

Front. Syst. Neurosci.

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Parkinson’s disease (PD) is a neurological disorder, associated with rigidity, bradykinesia, and resting tremor, among other motor symptoms. In addition, patients with PD also show cognitive and psychiatric dysfunction, including dementia, mild cognitive impairment (MCI), depression, hallucinations, among others. Interestingly, the occurrence of these symptoms—motor, cognitive, and psychiatric—vary among individuals, such that a subgroup of PD patients might show some of the symptoms, but another subgroup does not. This has prompted neurologists and scientists to subtype PD patients depending on the severity of symptoms they show. Neural studies have also mapped different motor, cognitive, and psychiatric symptoms in PD to different brain networks. In this review, we discuss the neural and behavioral substrates of most common subtypes of PD patients, that are related to the occurrence of: (a) resting tremor (vs. nontremor-dominant); (b) MCI; (c) dementia; (d) impulse control disorders (ICD); (e) depression; and/or (f) hallucinations. We end by discussing the relationship among subtypes of PD subgroups, and the relationship among motor, cognitive, psychiatric factors in PD.

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“…That patients who have alpha-synuclein pathology beginning on the left side, with relatively healthy right brain function, are less prone to depression is concordant with previous reports that depression is associated with decreased activity in the right dorsolateral prefrontal cortex, 26 but is discordant with studies of depression and lateralized onset of PD symptoms. 16, 17 …”

Section: Discussionmentioning

confidence: 99%

“…15 In 2 studies that assessed the relationship between depression severity and laterality of symptoms at disease onset, both found that right-sided onset was associated with more severe depressive symptoms. 16, 17 …”

mentioning

confidence: 99%

Motor Symptoms at Onset of Parkinson Disease and Risk for Cognitive Impairment and Depression

Dewey

Taneja²,

McClintock³

et al. 2012

Cognitive and Behavioral Neurology

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Objective To determine if side and type of initial motor symptoms in Parkinson disease predict risk for later development of cognitive impairment or depressive symptoms. Methods We recruited 124 nondemented patients with Parkinson disease to participate in a cohort study of cognitive function and depressive symptoms that used validated neuropsychological tests and a depressive symptom inventory. We first reviewed the patients’ charts to determine their initial motor symptom and side of onset, and then classified the patients into 4 groups: right-side onset tremor, right-side onset bradykinesia/rigidity, left-side onset tremor, and left-side onset bradykinesia/rigidity. We excluded patients with bilateral symptom onset. We used analysis of variance on neuropsychological test performance and depressive symptoms to determine if group classification affected risk of cognitive impairment or depressive symptoms. We controlled our analyses for disease duration and motor severity as measured by the Unified Parkinson Disease Rating Scale Part III motor score. Results There were no differences in any cognitive measure by side and type of initial motor symptoms. The right-side onset tremor group had the lowest depressive symptom scores, and no patient in any group reported severe depressive symptoms. Conclusion Our findings suggest that patterns of nigral cell loss correlating to the initial side and type of motor symptoms in Parkinson disease are not related to the risk of later cognitive impairment. By contrast, patients with right-side onset of tremor appear to have a lower risk of depressive symptoms than patients with other presentations.

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Anxiety and depression severity are related to right but not left onset Parkinson's disease duration

Cited by 29 publications

References 57 publications

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

Side‐of‐onset of Parkinson's disease in relation to neuropsychological measures

Neural and behavioral substrates of subtypes of Parkinson’s disease

Motor Symptoms at Onset of Parkinson Disease and Risk for Cognitive Impairment and Depression

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