Anxiety and Sensitivity to Ethanol and Pentobarbital in Alcohol Withdrawal Seizure‐Prone and Withdrawal Seizure‐Resistant Mice

Atkins, Alison Lynn; Rustay, Nathan R.; Crabbe, John C.

doi:10.1111/j.1530-0277.2000.tb01976.x

Cited by 13 publications

(5 citation statements)

References 38 publications

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“…While WSP and WSR mice showed behavioral differences in both the LDT and MBT, these were apparently in opposite directions, consistent with suggestions that the LDT and MBT may assay different phenotypic aspects of anxiety. In the present study, WSP mice displayed more anxiety‐like behavior than WSRs in the LDT, consistent with previous findings that WSP mice exhibit greater anxiety than WSRs in the elevated‐plus maze (Gorin et al., ) and canopy stretched‐attend‐posture (Atkins et al., ) tests. Conversely, however, WSRs (females) exhibited greater anxiety‐like behavior than WSPs on the MBT, possibly related to their slightly higher BECs relative to males.…”

Section: Discussionsupporting

confidence: 93%

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long‐Term Alcohol Abstinence

Hartmann

Holbrook

Haney

et al. 2019

Alcoholism Clin & Exp Res

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Background: While the acute alcohol withdrawal syndrome has been well characterized both in human clinical studies and in experimental animals, much less is known regarding long-term affective disturbances that can sometimes persist during protracted abstinence. Nevertheless, since relapse often occurs long after acute detoxification and may be predicted by persistent affective disruption, a better understanding of the long-term behavioral consequences of prior alcohol dependence may lead to improved strategies for relapse prevention.Methods: Male and female Withdrawal Seizure-Prone and Withdrawal Seizure-Resistant mice from the second selection replicate (WSP-2, WSR-2) were exposed to a 10-day chronic-intermittent ethanol vapor protocol (CIE) or plain air and then tested repeatedly on the sucrose preference test (SPT), marble burying test (MBT), and the light-dark box test (LDT) over 7 weeks of (forced) abstinence.Results: While WSP and WSR mice differed significantly on tests of anxiety-like behavior (LDT, MBT), we found little evidence for long-term affective disruption following CIE in either line. The major exception was in the LDT, in that WSP but not WSR mice displayed longer latencies to enter the light compartment following CIE relative to air-controls.Conclusions: Selective breeding for acute withdrawal severity has resulted in differences in anxietylike behavior between WSP and WSR mice. In contrast, however, genes contributing to the severity of acute withdrawal convulsions appear to have little overlap with those predisposing to affective disruption during long-term abstinence.

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Section: Discussionsupporting

confidence: 93%

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long‐Term Alcohol Abstinence

Hartmann

Holbrook

Haney

et al. 2019

Alcoholism Clin & Exp Res

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“…1), consistent with its effects in humans and animals (Abruzzi, 1964;Atkins et al, 2000) and similar to effects of some other GABAenhancing drugs (e.g., chlordiazepoxide) on zebrafish (Table 1). Recently suggested as a good model for studying GABA-ergic sedative agents, zebrafish possess multiple high-affinity sites and robust genomic/ proteomic responses to these drugs (Renier et al, 2007).…”

Section: Gaba-ergic Systemsupporting

confidence: 75%

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

Stewart

Cachat

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

215

121

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“…Withdrawal severity may also play a role in the development of alcoholism and drug abuse specifically by encouraging further drug use to relieve anxiety (Holter et al ). Work in mice selectively bred for high and low handling‐induced convulsions after chronic ethanol treatment appears to support this idea (Atkins et al ). Thus, convulsion‐prone mice showed higher levels of baseline anxiety and were more sensitive to the anxiolytic effects of alcohol than convulsion‐resistant mice, suggesting that convulsion‐prone animals may be genetically predisposed to severe alcohol withdrawal symptoms.…”

Section: Vulnerability Traitsmentioning

confidence: 99%

In search of predictive endophenotypes in addiction: insights from preclinical research

Belin

Everitt

et al. 2015

Genes Brain and Behavior

137

103

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Drug addiction is widely recognized to afflict some but not all individuals by virtue of underlying risk markers and traits involving multifaceted interactions between polygenic and external factors. Remarkably, only a small proportion of individuals exposed to licit and illicit drugs develop compulsive drug-seeking behavior, maintained in the face of adverse consequences and associated detrimental patterns of drug intake involving extended and repeated bouts of binge intoxication, withdrawal and relapse. As a consequence, research has increasingly endeavored to identify distinctive neurobehavioral mechanisms and endophenotypes that predispose individuals to compulsive drug use. However, research in active drug users is hampered by the difficulty in categorizing putatively causal behavioral traits prior to the initiation of drug use. By contrast, research in experimental animals is often hindered by the validity of approaches used to investigate the neural and psychological mechanisms of compulsive drug-seeking habits in humans. Herein, we survey and discuss the principal findings emanating from preclinical animal research on addiction and highlight how specific behavioral endophenotypes of presumed genetic origin (e.g. trait anxiety, novelty preference and impulsivity) differentially contribute to compulsive forms of drug seeking and taking and, in particular, how these differentiate between different classes of stimulant and non-stimulant drugs of abuse.

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Anxiety and Sensitivity to Ethanol and Pentobarbital in Alcohol Withdrawal Seizure‐Prone and Withdrawal Seizure‐Resistant Mice

Cited by 13 publications

References 38 publications

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long‐Term Alcohol Abstinence

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long‐Term Alcohol Abstinence

Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models

In search of predictive endophenotypes in addiction: insights from preclinical research

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