Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis

Gulpers, Bernice; Ramakers, Inez H.G.B.; Hamel, Renske; Köhler, Sebastian; Voshaar, Richard C. Oude; Verhey, Frans R.J.

doi:10.1016/j.jagp.2016.05.015

Cited by 326 publications

(209 citation statements)

References 49 publications

Supporting

Mentioning

182

Contrasting

Unclassified

Order By: Relevance

“…The therapeutic use of procognitive compounds might be integrated into a stressful context. Indeed, patients suffering cognitive deficits often show anxiety disorders and stress impairs hippocampus‐dependent memory retrieval . The deleterious effect of stress on cognitive functions is observed in stress‐related disorders such as anxiety and depression .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Chauveau¹,

Job²,

Poly-Thomasson³

et al. 2019

CNS Neurosci Ther

View full text Add to dashboard Cite

Summary Aim Although cognitive deficits commonly co‐occur with stress‐related emotional disorders, effect of procognitive drugs such as histaminergic H 3 receptor antagonists are scarcely studied on memory retrieval in stress condition. Methods Experiment 1 . Memory of two successive spatial discriminations (D1 then D2) 24 hours after learning was studied in a four‐hole board in mice. H3 receptor antagonist ciproxifan ( ip 3 mg/kg) and acute stress (three electric footshocks; 0.9 mA; 15 ms) were administered 30 and 15 minutes respectively before memory retrieval test. Fos immunostaining was performed to evaluate the neural activity of several brain areas. Experiment 2 . Effects of ciproxifan and acute stress were evaluated on anxiety‐like behavior in the elevated plus maze and glucocorticoid activity using plasma corticosterone assay. Results Experiment 1 . Ciproxifan increased memory retrieval of D2 in nonstress condition and of D1 in stress one. Ciproxifan mitigated the stress‐induced increase of Fos expression in the prelimbic and infralimbic cortex, the central and basolateral amygdala and the CA1 of dorsal hippocampus. Experiment 2 . Ciproxifan dampened the stress‐induced anxiety‐like behavior and plasma corticosterone increase. Conclusion Ciproxifan improved contextual memory retrieval both in stress and nonstress conditions without exacerbating behavioral and endocrine responses to stress. Overall, these data suggest potential usefulness of H 3 receptor antagonists as cognitive enhancer both in nonstress and stress conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

“…cognitive deficits often show anxiety disorders 22 and stress impairs hippocampus-dependent memory retrieval. 23 The deleterious effect of stress on cognitive functions is observed in stress-related disorders such as anxiety and depression.…”

mentioning

confidence: 99%

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Chauveau¹,

Job²,

Poly-Thomasson³

et al. 2019

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…The association between depression and anxiety, social relationships, and cognitive health is complex, as although good social relationships may enhance wellbeing, individuals who have greater wellbeing may experience better social relationships (Diener & Seligman, 2004). In addition, depression and anxiety are associated with poor cognitive function (Aggarwal, Kunik, & Asghar-Ali, 2017;Pietrzak et al, 2012;Potvin, Forget, Grenier, Pr eville, & Hudon, 2011;Yochim, Mueller, & Segal, 2013) and an increased risk of dementia (Burton, Campbell, Jordan, Strauss, & Mallen, 2012;Diniz, Butters, Albert, Dew, & Reynolds, 2013;Gulpers et al, 2016). However, findings are inconsistent and some studies report that although depression or anxiety may accompany poor cognitive function, symptoms of depression and anxiety do not necessarily precede poor cognitive function (Andreescu et al, 2014;Okereke & Grodstein, 2013;Potvin et al, 2013;Richard et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety

Evans

Llewellyn

Matthews

et al. 2018

Aging & Mental Health

View full text Add to dashboard Cite

Objectives: Poor social connections may be associated with poor cognition in older people who are not experiencing mental health problems, and the trajectory of this association may be moderated by cognitive reserve. However, it is unclear whether this relationship is the same for older people with symptoms of depression and anxiety. This paper aims to explore social relationships and cognitive function in older people with depression and anxiety. Method: Baseline and two-year follow-up data were analysed from the Cognitive Function and Ageing Study-Wales (CFAS-Wales). We compared levels of social isolation, loneliness, social contact, cognitive function, and cognitive reserve at baseline amongst older people with and without depression or anxiety. Linear regression was used to assess the relationship between isolation and cognition at baseline and two-year follow-up in a subgroup of older people meeting pre-defined criteria for depression or anxiety. A moderation analysis tested for the moderating effect of cognitive reserve. Results: Older people with depression or anxiety perceived themselves as more isolated and lonely than those without depression or anxiety, despite having an equivalent level of social contact with friends and family. In people with depression or anxiety, social isolation was associated with poor cognitive function at baseline, but not with cognitive change at two-year follow-up. Cognitive reserve did not moderate this association. Conclusion: Social isolation was associated with poor cognitive function at baseline, but not twoyear follow-up. This may be attributed to a reduction in mood-related symptoms at follow-up, linked to improved cognitive function. ARTICLE HISTORY

show abstract

“…Both conditions are highly prevalent and are leading causes of disease burden and disability (Kessler et al 2009; Whiteford et al 2013). Depression and anxiety have also been associated with higher risk of major somatic conditions and adverse health outcomes (Batelaan et al 2016; Gan et al 2014; Mezuk et al 2008; Luppino et al 2011; Gulpers et al 2016; Cuijpers et al 2013; Chodosh et al 2007). Although the underlying biological mechanisms involved in depression and anxiety are unknown, it has been hypothesized that immune dysregulation or dysfunction, oxidative stress and/or inflammation may be involved (Raison, Capuron, and Miller 2006; Dantzer et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Prospective association of depression and phobic anxiety with changes in telomere lengths over 11 years

et al. 2018

View full text Add to dashboard Cite

show abstract

Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis

Cited by 326 publications

References 49 publications

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety

Prospective association of depression and phobic anxiety with changes in telomere lengths over 11 years

Contact Info

Product

Resources

About

Anxiety as a Predictor for Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis

Cited by 326 publications

References 49 publications

Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress

Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress

Social isolation, cognitive reserve, and cognition in older people with depression and anxiety

Prospective association of depression and phobic anxiety with changes in telomere lengths over 11 years

Contact Info

Product

Resources

About

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress

Procognitive impact of ciproxifan (a histaminergic H₃ receptor antagonist) on contextual memory retrieval after acute stress