Anxiety, Insomnia, and Memory Impairment in Metabolic Syndrome Rats Are Alleviated by the Novel Functional Ingredients from Anacardium occidentale

Srichomphu, Pratthana; Thukham-mee, Wipawee; Muchimapura, Supaporn

doi:10.3390/antiox11112203

Cited by 4 publications

(3 citation statements)

References 81 publications

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“…Oxidative stress markers such as malondialdehyde (MDA) levels and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were assessed according to the method mentioned in the study by Srichomphu and coworkers [ 30 ].…”

Section: Methodsmentioning

confidence: 99%

Omega-3-Rich Tuna Oil Derived from By-Products of the Canned Tuna Industry Enhances Memory in an Ovariectomized Rat Model of Menopause

Wattanathorn,

Thukham-Mee

2024

Antioxidants

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To increase the value of the by-products of the canned tuna industry, the memory enhancement effect and the possible mechanisms of omega-3-rich tuna oil in bilateral ovariectomized (OVX) rats were assessed. Female rats were orally given tuna oil at doses of 140, 200, and 250 mg/kg of body weight (BW) for 28 days before OVX and for 21 days continually after OVX. Memory performance was assessed every week, whereas the parameters regarding mechanisms of action were assessed at the end of the study. All doses of tuna oil enhanced memory, docosahexaenoic acid (DHA) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities but decreased cortisol, acetylcholinesterase (AChE), malondialdehyde (MDA), and inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Medium and high doses of tuna oil suppressed monoamine oxidase (MAO) but increased eNOS activity. A high dose of tuna oil suppressed gamma-aminotransferase (GABA-T) but increased glutamic acid decarboxylase (GAD) and sirtuin-1. A medium dose of tuna oil decreased homocysteine (Hcys) and C-reactive protein. No change in telomere or estradiol was observed in this study. Our results suggest the memory-enhancing effect of tuna oil in an OVX rat model of menopause. The main mechanisms may involve a reduction in oxidative stress, inflammation, and neurotransmitter regulation.

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Section: Methodsmentioning

confidence: 99%

Omega-3-Rich Tuna Oil Derived from By-Products of the Canned Tuna Industry Enhances Memory in an Ovariectomized Rat Model of Menopause

Wattanathorn,

Thukham-Mee

2024

Antioxidants

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“…The neurotransmitter disturbances, including the alterations of acetylcholine (ACh), gamma aminobutyric acid (GABA), and monoamine oxidase (MAO; total MAO, MAO-A, MAO-B)), were indirectly performed by measuring the suppression activities of acetylcholinesterase (AChE), GABA-transaminase (GABA-T), and all forms of monoamine oxidase (MAO) by using the modified method of Srichomphu and colleagues, as previously mentioned [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

A Randomized, Double-Blind, Placebo-Controlled Study of an Anthocyanin-Rich Functional Ingredient on Cognitive Function and Eye Dryness in Late Adulthood Volunteers: Roles of Epigenetic and Gut Microbiome Modulations

et al. 2023

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Due to the rising demand for supplements targeting cognitive enhancement and dry eye together with the health benefits of anthocyanins, we have developed a functional soup containing an anthocyanin-rich functional ingredient, or “Anthaplex,” and assessed the effects on cognitive function and eye dryness together with the possible mechanisms. A total of 69 male and female health volunteers were randomized and divided into placebo, D2, and D4 groups. All subjects consumed 120 mL of placebo or functional soup containing “Anthaplex” either at 2 or 4 g per serving per day within 5 min in the morning for eight weeks. The cognitive function, working memory, dry eye, AChE, MAO, MAO-A, MAO-B, and GABA-T activities, BDNF, HAC, HDAC, and DNMT activities, pH, and amount of lactic acid-producing bacteria, particularly Lactobacillus and Bifidobacterium spp. in feces, were determined before intervention and after eight weeks of consumption. Subjects who consumed the “Anthaplex” soup had improved cognitive function, working memory, eye dryness, histone acetylation, ACh E suppression, and BDNF with increased Bifidobacterium spp. but decreased pH in feces. These data suggest that “Anthaplex” improves cognitive function and eye dryness via the modulations of the histone acetylation process, gut microbiome, and cholinergic function.

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“…Changing the balance of neurotransmitters can cause psychiatric problems, anxiety, insomnia, depression, and memory impairment. Especially, monoamine imbalance plays an important role in mood disorders, and MAO inhibition can improve mood disorders such as anxiety and depression (Srichomphu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor

Akıncıoğlu

2024

Drug Development Research

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In this study, a series of novel benzyloxybenzene substituted (S)‐α‐amino acid methyl esters and their amide derivatives were synthesized and evaluated for their inhibitory actions against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), monoamine oxidase A (MAO‐A), and monoamine oxidase B (MAO‐B). The synthetic strategy was based on starting from benzyl bromide (5) and 4‐hydroxybenzaldehyde (6). The reaction of 5 and 6 in the presence of K2CO3 gave benzyloxybenzaldehyde 7. Benzyloxybenzene substituted (S)‐α‐amino acid methyl esters 11, 12, 13, (±)‐19, and (±)‐20 were obtained from the reaction of L‐amino acid methyl esters with benzyloxybenzaldehyde (7) followed by in situ reduction with NaBH4. The reaction of (S)‐11, (S)‐12, 13, (±)‐19, and (±)‐20 with excess ammonia gave amides (S)‐14, (S)‐15, 16, (±)‐21, and (±)‐22. The in vitro inhibitory activities of compounds against MAO‐A, MAO‐B, AChE, and BChE were investigated. Within the α‐amino acid methyl ester series, 13 (21.32 ± 0.338 µM) showed selectivity by inhibiting the MAO‐B better than MAO‐A. 13 emerged as the most active member of this series, exhibiting a 12‐fold selectivity for MAO‐B. 14 (4.501 ± 0.295 µM) demonstrated a pronounced selectivity for MAO‐A over MAO‐B, with a selectivity ratio of 110‐fold. In addition, it was determined that compound 15 (95.65 ± 3.09 µM) had high selectivity for BChE inhibition. 21 was demonstrated the most potent inhibition (18.36 ± 1.36 µM) against AChE.

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Anxiety, Insomnia, and Memory Impairment in Metabolic Syndrome Rats Are Alleviated by the Novel Functional Ingredients from Anacardium occidentale

Cited by 4 publications

References 81 publications

Omega-3-Rich Tuna Oil Derived from By-Products of the Canned Tuna Industry Enhances Memory in an Ovariectomized Rat Model of Menopause

Omega-3-Rich Tuna Oil Derived from By-Products of the Canned Tuna Industry Enhances Memory in an Ovariectomized Rat Model of Menopause

A Randomized, Double-Blind, Placebo-Controlled Study of an Anthocyanin-Rich Functional Ingredient on Cognitive Function and Eye Dryness in Late Adulthood Volunteers: Roles of Epigenetic and Gut Microbiome Modulations

Design, synthesis, in silico, and in vitro evaluation of novel benzyloxybenzene substituted (S)‐α‐amino amide derivatives as cholinesterases and monoaminoxidases inhibitor

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