Anxiety, insomnia, depression — in conjunction with or opposite to functional disorders

Yakupov, E. Z.; Troshina, Yu. V.

doi:10.17116/jnevro201611651119-124

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Psychological distress will be an inevitable result as time passes [8]. It is very di cult to correct anxiety and depressive disorders built up subsequently [9,10]. Whereas, psychological distress will induce or exacerbate the original symptoms including insomnia and pain.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Rotator Cuff Repair on the Clinical and Psychological Meaningful Improvement in Patients with Rotator Cuff Tear and Insomnia.

Tong¹,

Wu²,

Liu³

et al. 2020

Preprint

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Background: Rotator cuff repair is widely used to treat rotator cuff tear, but its impact on the psychological status in patients with rotator cuff tears and insomnia is still poorly understood.Methods: 240 patients were enrolled who underwent rotator cuff repair at the first affiliated hospital of soochow university from 2014-2018. During the 2-year follow-up period, the patients were assessed preoperatively and postoperatively at 3 months, 6 months, 12 months and 24 months by using Constant, Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), American Shoulder and Elbow Surgeons’ Scale (ASES), Hospital Anxiety and Depression Scale, depression subsection (HADS-D), Hospital Anxiety and Depression Scale, anxiety subsection (HADS-A), and World Health Organization Quality-of-life Scale Abbreviated Version (WHOQOL-BREF).Results: Finally, a total of 240 patients were enrolled in this study and finished the 2 year follow-up.There were 107 men(43.8%) and 133 women(56.2%), and the mean age of the patients was 54.2±7.5 years. With the prolongation of postoperative time, pain, activity of daily life, joint mobility and muscle strength were gradually improved from 4.8 ± 2.2, 7.2 ± 3.4, 14.2 ± 5.5, 7.8 ± 3.5, and 34.0 ± 11.3, respectively, before surgery to 13.2 ± 3.2, 17.8 ± 2.8, 34.0 ± 6.4, 21.0 ± 4.0, and 85.9 ± 12.4, at 2 years after surgery, which was statistically significant (P < 0.001).The scores of ASES and WHOQOL-BREF also increased significantly from 40.5 ± 9.6, 58.3 ± 8.6 before operation to 87.7 ± 10.2, 69.3 ± 7.9 at two years after operation (P < 0.001). HADS-A decreased linearly from 4.8±2.4 before operation to 1.4 ± 1.2 at two years after operation (P < 0.01). The pain scores had a highly positive correlation with the Constant and the ASES scores. The PSQI and the ISI scores had a positive correlation with the HADS-A scores.Conclusion: For the patients with rotator cuff tears and insomnia, rotator cuff repair may contribute to the improvement of clinical outcome and status of anxiety.

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Section: Introductionmentioning

confidence: 99%

The Effect of Rotator Cuff Repair on the Clinical and Psychological Meaningful Improvement in Patients with Rotator Cuff Tear and Insomnia.

Tong¹,

Wu²,

Liu³

et al. 2020

Preprint

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“…Insomnia is a neurological disorder characterized by early awakening and difficulty in falling asleep. It has become the direct or indirect cause of more than 80 diseases including depression − and cardiovascular diseases. , Aserinsky and Kleitman , divided sleep into rapid eye movement (REM) sleep and nonrapid eye movement (non-REM, NREM) sleep based on characteristics of rapid eye movement. NREM sleep is the main episode of adult physiological-like sleep. , In particular, deep NREM sleep plays important roles in maintaining immune functions, − learning, and memory capabilities. , Deep NREM sleep is increased in a compensatory manner in both animals and humans after sleep deprivation. , Rechtschafffen and Kales divided NREM sleep into four phases based on the electroencephalogram (EEG) structure .…”

Section: Introductionmentioning

confidence: 99%

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep

Yang¹,

Wang²,

Guan³

et al. 2019

Mol. Pharmaceutics

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Honokiol (HNK) is a small-molecule lignin extracted from Magnolia Officinalis, demonstrating high potency in promoting nonrapid eye movement (NREM) sleep by modulating the benzodiazepine site of the GABAA receptor. However, the clinical use of HNK in the treatment of insomnia is restricted by its extremely low oral bioavailability. In the present work, enhanced oral bioavailability of HNK was achieved by loading it into poly lactide–glycolide acid microparticles (HNK-MP). After oral administration, HNK-MP demonstrated 15-fold increase of AUC0–12 h in comparison to free HNK. The maximum blood concentration (C max) of HNK in HNK-MP-treated rats was 3.6 μg/mL at 2 h after oral administration, which was 6.5-fold of that in free HNK-treated rats. Oral administration of HNK-MP (20 mg/kg) efficiently increased NREM sleep by 60% by enhancing the transition from wakefulness to NREM sleep in rats. The biosafety of HNK-MP was assessed in vivo, and no damage occurred in the gastrointestinal tract. The present study provides a promising oral HNK formulation for the treatment of insomnia.

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Association of sleep quality with distribution of cardiovascular diseases' psychosocial risk factors in the open urban population

Akimova,

Kayumova,

Gakova

et al. 2024

Rus. J. Prev. Med.

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Anxiety, insomnia, depression — in conjunction with or opposite to functional disorders

Cited by 5 publications

References 33 publications

The Effect of Rotator Cuff Repair on the Clinical and Psychological Meaningful Improvement in Patients with Rotator Cuff Tear and Insomnia.

The Effect of Rotator Cuff Repair on the Clinical and Psychological Meaningful Improvement in Patients with Rotator Cuff Tear and Insomnia.

Oral Delivery of Honokiol Microparticles for Nonrapid Eye Movement Sleep

Association of sleep quality with distribution of cardiovascular diseases' psychosocial risk factors in the open urban population

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