Anxiety-like behavior and neuroendocrine changes in offspring resulting from gestational post-traumatic stress disorder

Chagas, Luana A.; Batista, Tatiane Helena; Ribeiro, Ana Cláudia Alves Freire; Ferrari, Mariela S.; Vieira, Jádina S.; Rojas, Viviana Carolina Trujillo; Kalil-Cutti, Bruna; Elias, Lucila Leico Kagohara; Giusti‐Paiva, Alexandre; Vilela, Fabiana C.

doi:10.1016/j.bbr.2020.113026

Cited by 11 publications

(4 citation statements)

References 35 publications

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“…The arena was carefully cleaned with a 5% ethanol solution after each test. This test was performed on lactating rats in PND 6 and in offspring in PND 28–32 (Chagas et al, 2021 de Novais et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Perinatal exposure to glyphosate‐based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring

Oliveira

Rojas

Sá

et al. 2022

Intl J of Devlp Neuroscience

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Glyphosate is the organophosphate pesticide most widely used in the world. Recent studies correlate exposure to glyphosate and the emergence of neurodevelopmental disorders. Therefore, it was objective to propose a rat model of perinatal exposure to glyphosate-based herbicides (GBH) to study associated neurodevelopmental disorders. Behavioral aspects and brain pathways were assessed in the prepubertal phase. For this, maternal treatment occurred throughout the entire gestation period (from GD0) until weaning on postnatal day 22 (PND 22). Control group received oral gavage with 5 mL/kg of saline per day and GBH group received oral gavage with 50 mg/kg of GBH per day (n = 10 per group). Maternal behavior was evaluated in PND 2-6. Offspring were evaluated for quantification of ultrasonic vocalizations (PND 5); homing behavior test (PND 13); and hole board, social play behavior, open field, and object recognition tests . Prefrontal cortex and hippocampus of the offspring were processed to evaluate oxidative stress. Maternal exposure to GBH impaired early social communication, olfactory discrimination, social play behavior, and the exploration of objects, in addition to increasing repetitive and stereotyped movements. GBH also increased oxidative stress. Therefore, perinatal GBH exposure induced behavioral and oxidative stress impairments in rats associated with neurodevelopmental disorders. The manifestations found in the offspring are in accordance with symptoms of autism spectrum disorder.

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Section: Methodsmentioning

confidence: 99%

Perinatal exposure to glyphosate‐based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring

Oliveira

Rojas

Sá

et al. 2022

Intl J of Devlp Neuroscience

Self Cite

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“…The development process is characterized by multiple time windows in which organisms have strong plasticity and are very sensitive to environmental stimuli ( Musillo, Berry & Cirulli, 2022 ). Embryonic stage is the key period of brain development, studies have found that prenatal maternal stress have an adverse effect on the emotional and cognitive development of their offspring ( Chagas et al, 2021 ; Charrier et al, 2022 ; Glynn & Baram, 2019 ; Marchisella et al, 2021 ; Sandman et al, 2018 ). The hypothalamic pituitary adrenal (HPA) axis is a physiological system and play a key role in regulating the relationship between prenatal maternal stress and offspring development outcomes ( Constantinof, Moisiadis & Matthews, 2016 ; Nakamura, Osonoi & Terauchi, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Zhao

Wang

Wen

et al. 2022

PeerJ

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Background Numerous studies have shown that exposure to prenatal maternal stress (PMS) is associated with various psychopathological outcomes of offspring. The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota-gut-brain axis) has been aconsensus; however, there is a lack of research on the involvement mechanism of gut microbiota in the regulation of the BDNF/CREB signaling pathway in the hippocampus of prenatally stressed offspring. Methods Pregnant rats were subjected to chronic unpredictable mild stress (CUMS) to establish the prenatal maternal stress model. The body weight was measured and the behavioral changes were recorded. Offspring were tested to determine emotional state using sucrose preference test (SPT), open-field test (OFT) and suspended tail test (STT). Gut microbiota was evaluated by sequencing the microbial 16S rRNA V3–V4 region, and the interactive analysis of bacterial community structure and diversity was carried out. The expression of hippocampal BDNF, TrkB and CREB mRNA and proteins were respectively measured using RT-PCR and Western blotting. Results Prenatal maternal stress increased maternal plasma corticosterone levels, slowed maternal weight gain and caused depression-like behaviors (all P < 0.05). In offspring, prenatal maternal stress increased plasma corticosterone levels (P < 0.05) and emotional behavior changes (depression-like state) were observed (P < 0.05). The species abundance, diversity and composition of the offspring’s gut microbiota changed after the maternal stress during pregnancy (P < 0.05). Compared with the control group’s offspring, the species abundance of Lactobacillaceae was dropped, while the abundance of the Muribaculaceae species abundance was risen. Concurrent, changes in the hippocampal structure of the offspring and decreases in expression of BDNF/CREB signaling were noted (P < 0.05). Conclusions Prenatal maternal stress leads to high corticosterone status and abnormal emotion behavior of offspring, which may be associated with the abnormal BDNF/CREB signaling in hippocampus of offspring caused by the change of gut microbiota composition.

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“…Social hierarchy is associated with a variety of physiological and biochemical responses. For instance, group members of different social status accordingly exhibit different hormone levels, urinary protein content, and body temperature regulation [ 5 , 7 , 8 , 9 ]. Aggressive behavior among animals is a connatural heritable trait contributing to the establishment of social hierarchy [ 3 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner

Zeng

Liu

Dong

et al. 2022

IJMS

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Social hierarchy governs the physiological and biochemical behaviors of animals. Intestinal radiation injuries are common complications connected with radiotherapy. However, it remains unclear whether social hierarchy impacts the development of radiation-induced intestinal toxicity. Dominant mice exhibited more serious intestinal toxicity following total abdominal irradiation compared with their subordinate counterparts, as judged by higher inflammatory status and lower epithelial integrity. Radiation-elicited changes in gut microbiota varied between dominant and subordinate mice, being more overt in mice of higher status. Deletion of gut microbes by using an antibiotic cocktail or restructuring of the gut microecology of dominant mice by using fecal microbiome from their subordinate companions erased the difference in radiogenic intestinal injuries. Lactobacillus murinus and Akkermansia muciniphila were both found to be potential probiotics for use against radiation toxicity in mouse models without social hierarchy. However, only Akkermansia muciniphila showed stable colonization in the digestive tracts of dominant mice, and significantly mitigated their intestinal radiation injuries. Our findings demonstrate that social hierarchy impacts the development of radiation-induced intestinal injuries, in a manner dependent on gut microbiota. The results also suggest that the gut microhabitats of hosts determine the colonization and efficacy of foreign probiotics. Thus, screening suitable microbial preparations based on the gut microecology of patients might be necessary in clinical application.

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Anxiety-like behavior and neuroendocrine changes in offspring resulting from gestational post-traumatic stress disorder

Cited by 11 publications

References 35 publications

Perinatal exposure to glyphosate‐based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring

Perinatal exposure to glyphosate‐based herbicides induced neurodevelopmental behaviors impairments and increased oxidative stress in the prefrontal cortex and hippocampus in offspring

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner

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