Anxiety-like behavior in crayfish is controlled by serotonin

Fossat, Pascal; Bacqué-Cazenave, Julien; Deurwaerdère, Philippe De; Delbecque, Jean‐Paul; Cattaert, Daniel

doi:10.1126/science.1248811

Cited by 223 publications

(213 citation statements)

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“…This state of higher alertness is called anxiety (Blanchard and Blanchard, 1988;Belzung and Philippot, 2007;Steimer, 2011). Recently, it has been shown that anxiety-like behavior (ALB) is also observable in crustaceans (Fossat et al, 2014), allowing the study of primitive forms of anxiety and of their neurobiological correlates.…”

Section: Introductionmentioning

confidence: 99%

“…More particularly, the biogenic amines serotonin (5-HT) and dopamine (DA) have been involved in fear responses and anxiety in mammals (Bonhomme and Esposito, 1998;Nutt, 2001;Graeff and Zangrossi, 2010;Canteras and Graeff, 2014;Fossat et al, 2014;Zangrossi and Graeff, 2014). In crayfish and other decapods, 5-HT has been shown to control the stress response by raising secretion of crustacean hyperglycemic hormones (CHHs), leading to an increase in blood glucose (Lorenzon et al, 2005;Fossat et al, 2014). DA has been also claimed to have such a role, although conflicting observations have been reported (Sarojini et al, 1995;Zou et al, 2003;Lorenzon et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…DA has been also claimed to have such a role, although conflicting observations have been reported (Sarojini et al, 1995;Zou et al, 2003;Lorenzon et al, 2005). Downstream from the stress response, 5-HT is able to trigger ALB in crayfish (Fossat et al, 2014), but the possible role of DA on this behavior has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

“…For this purpose, we submitted animals to electric field stress, and then transferred them to a dark/light plus maze, as previously described (Fossat et al, 2014). In order to verify whether ALB is dependent on the intensity of the aversive stimulus, we applied various stress intensities and measured the brain levels of 5-HT and DA.…”

Section: Introductionmentioning

confidence: 99%

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Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

Fossat

Bacqué-Cazenave

Deurwaerdère

et al. 2015

Journal of Experimental Biology

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In the animal kingdom, biogenic amines are widespread modulators of the nervous system that frequently interact to control mood. Our previous investigations in crayfish (Procambarus clarkii) have established that stress induces changes in brain serotonin (5-HT) concentrations that are responsible for the appearance of anxiety-like behavior (ALB). Here, we further analyze the roles of 5-HT and another biogenic amine, dopamine (DA), on the crayfish response to stress. We show that the intensity of crayfish ALB depends on the intensity of stressful stimulation and is associated with increased concentrations of 5-HT in the brain. These 5-HT levels were significantly correlated, before, as well as after stress, with those of DA, which were approximately 3-to 5-times less abundant. However, whereas the degree of ALB was clearly correlated with brain 5-HT concentrations, it was not significantly correlated with DA. Moreover, in contrast to injections of 5-HT, DA injections were not able to elicit a stress response or ALB. In addition, 5-HT and DA levels were not modified by treatment with the anxiolytic chlordiazepoxide, confirming that suppression of ALB by this GABA-A receptor ligand acts downstream and is independent of changes in crayfish bioamine levels. Our study also provides evidence that the anxiogenic effect of 5-HT injections can be prevented by a preliminary injection of 5-HT antagonists. Altogether, our results emphasize that the rises in brain concentrations of 5-HT, but not DA, play a role in controlling the induction and the intensity of crayfish ALB.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

Fossat

Bacqué-Cazenave

Deurwaerdère

et al. 2015

Journal of Experimental Biology

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“…In arthropods, recent studies also described emotional-like behaviours in crayfish which were controlled by neurochemical (serotonergic) mechanisms (e.g. Fossat et al, 2014).…”

Section: The Emergence Of Consciousness In Phylogenymentioning

confidence: 99%

Animal Consciousness

Neindre¹,

Bernard

Boissy

et al. 2017

EFSA Supporting Publications

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After reviewing the literature on current knowledge about consciousness in humans, we present a state-of-the art discussion on consciousness and related key concepts in animals. Obviously much fewer publications are available on non-human species than on humans, most of them relating to laboratory or wild animal species, and only few to livestock species. Human consciousness is by definition subjective and private. Animal consciousness is usually assessed through behavioural performance. Behaviour involves a wide array of cognitive processes that have to be assessed separately using specific experimental protocols. Accordingly, several processes indicative of the presence of consciousness are discussed: perception and cognition, awareness of the bodily-self, selfrelated knowledge of the environment (including social environment). When available, specific examples are given in livestock species. Next, we review the existing evidence regarding neuronal correlates of consciousness, and emphasize the difficulty of linking aspects of consciousness to specific neural structures across the phyla because high-level cognitive abilities may have evolved independently along evolution. Several mammalian brain structures (cortex and midbrain) are involved in the manifestations of consciousness, while the equivalent functional structures for birds and fishes would likely be the pallium/tectum and midbrain. Caution is required before excluding consciousness in species not having the same brain structures as the mammalian ones as different neural architectures may mediate comparable processes. Finally, specific neurophysiological mechanisms appear to be strongly linked to the emergence of consciousness, namely neural synchrony and neural feedback. Considering the limited amount of data available and the few animal species studied so far, we conclude that different manifestations of consciousness can be observed in animals but that further refinement is still needed to characterize their level and content in each species. Further research is required to clarify these issues, especially in livestock species.

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Decapod crustaceans

Elwood,

Ingle

2024

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals

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Anxiety-like behavior in crayfish is controlled by serotonin

Cited by 223 publications

References 29 publications

Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

Animal Consciousness

Decapod crustaceans

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