Anxiety scores before and after genetic sonogram

Api, Oluş; Demir, Hacer; Apı, Murat; Tamer, İsmet; Orbay, Ekrem; Ünal, Orhan

doi:10.1007/s00404-009-0959-6

Cited by 6 publications

(7 citation statements)

References 15 publications

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“…This medical uncertainty is likely to affect the cost of prenatal screening for fetal anomalies and to generate unnecessary parental anxiety. The impact of the suspicion of a fetal anomaly is known to undermine the attachment of the pregnant woman to her pregnancy with a significant and prolonged impact even when reaching a favorable prognosis (4). Given the growing complexity of medical knowledge and the increasing availability of data sources, decision support systems (DSS) have been developed to assist clinicians in their decision-making, particularly for rare diseases diagnosis (5,6).…”

Section: Introductionmentioning

confidence: 99%

Description and clinical validation of a real-time AI diagnostic companion for fetal ultrasound examination

Stirnemann

Besson²,

Spaggiari

et al. 2021

Preprint

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Objective: To describe a real-time decision support system (DSS), named SONIO, to assist ultrasound-based prenatal diagnosis and to assess its performance using a clinical database of precisely phenotyped postmortem examinations. Population and Methods: This DSS is knowledge-based and comprises a dedicated thesaurus of 294 syndromes and diseases. It operates by suggesting, at each step of the ultrasound examination, the best next symptom to check for in order to optimize the diagnostic pathway to the smallest number of possible diagnoses. This assistant was tested on a single-center database of 251 cases of postmortem phenotypes with a definite diagnosis. Adjudication of discordant diagnoses was made by a panel of external experts. The primary outcome was a target concordance rate >90% between the postmortem diagnosis and the top-7 diagnoses given by SONIO when providing the full phenotype as input. Secondary outcomes included concordance for the top-5 and top-3 diagnoses; We also assessed a '1-by-1' model, providing only the anomalies sequentially prompted by the system, mimicking the use of the software in a real-life clinical setting. Results: The validation database covered 96 of the 294 (32.65%) syndromes and 79% of their overall prevalence in the SONIO thesaurus. The adjudicators discarded 42/251 cases as they were not amenable to ultrasound based diagnosis. SONIO failed to make the diagnosis on 7/209 cases. On average, each case displayed 6 anomalies, 3 of which were considered atypical for the condition. Using the 'full-phenotype' model, the success rate of the top-7 output of Sonio was 96.7% (202/209). This was 91.9% and 87.1% for the top-5 and top-3 outputs respectively. Using the '1-by-1' model, the correct diagnosis was within the top-7, top-5 and top-3 of SONIO's output in 72.4%, 69.3% and 63.1%. Conclusion: Sonio is a robust DSS with a success-rate >95% for top-7 ranking diagnoses when the full phenotype is provided, using a large database of noisy real data. The success rate over 70% using the '1-by-1' model was understandably lower, given that SONIO's sequential queries may not systematically cover the full phenotype.

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Section: Introductionmentioning

confidence: 99%

Description and clinical validation of a real-time AI diagnostic companion for fetal ultrasound examination

Stirnemann

Besson²,

Spaggiari

et al. 2021

Preprint

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“…Noninvasive prenatal screening in the first trimester of pregnancy is a standard procedure in most countries. Although screening has obvious medical benefits, studies over the last 10 years have drawn attention to its psychological impact and suggest that it could be an emotional strain on pregnant women and their partners . Anxiety is one of the most studied emotional variables in this context.…”

Section: Introductionmentioning

confidence: 99%

“…Although screening has obvious medical benefits, studies over the last 10 years have drawn attention to its psychological impact and suggest that it could be an emotional strain on pregnant women and their partners. [1][2][3] Anxiety is one of the most studied emotional variables in this context. It has been shown to be highest before the test and, when results are negative, to diminish afterwards.…”

Section: Introductionmentioning

confidence: 99%

Anxiety, depression, and attachment before and after the first-trimester screening for Down syndrome: comparing couples who undergo ART with those who conceive spontaneously

Udry-Jørgensen

Darwiche

Germond³

et al. 2015

Prenat Diagn

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Objectives This study's aim was to describe the emotional status of parents to be before and after the first-trimester combined prenatal screening test.Methods One hundred three couples participated, of which 52 had undergone an in vitro fertilization/intracytoplasmic sperm injection treatment [assisted reproductive technology (ART)] and 51 had conceived spontaneously. Participants completed the state scale of the State-trait Anxiety Inventory, the Edinburgh Depression Scale, and the Maternal and Paternal Antenatal Attachment Questionnaire before the first-trimester combined prenatal screening test at around 12 weeks of gestational age (T1) and just after receiving the results at approximately 14 weeks of gestational age (T2). ResultsWe observed a significant decrease in anxiety and depression symptoms and a significant increase in attachment from T1 to T2. Results showed no differences between groups at either time point, which suggests that ART parents are more similar to than different from parents conceiving spontaneously. Furthermore, given the importance of anxiety during pregnancy, a subsample of women with clinical anxiety was identified. They had significantly higher rates of clinical depression and lower attachment.Conclusions These results indicate that, regardless of whether conception was through ART or spontaneous, clinical anxiety in women over the prenatal testing period is associated with more vulnerability during pregnancy (i.e. clinical depression and less attachment to fetus).

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“…In addition, ultrasound may also increase maternal‐fetal attachment . However, a reduction in the anxiety and worry in pregnant women after second‐trimester ultrasound procedures has been observed, implying that anxiety was elevated before the procedure and that anxiety and stress are not associated to invasive procedures exclusively. Other recent studies did not show any differences in emotional mood and anxiety between women undergoing amniocentesis and ultrasound .…”

Section: Introductionmentioning

confidence: 99%

“…Different self‐report measures of general anxiety have been validated in pregnant women, with the General Health Questionnaire and the State‐Trait Anxiety Inventory (STAI) most commonly used . Distress due to amniocentesis or other prenatal diagnostic procedures has been measured predominantly with the STAI . A few studies have used the Visual Analogue Scale, the Perceived Stress Scale or depression measures .…”

Section: Introductionmentioning

confidence: 99%