Anxiolytic activity of ethanolic extract of aerial parts of Tribulus terrestris in mice

Kafeel, Huda; Rukh, Ramsha

doi:10.31254/phyto.2015.4104

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…Previous study had shown that Tribulus terrestris has an important role in protecting the liver from toxic substances (10) . This plant acts as an antioxidant against free radicals (11,12) , anticancer, (13) metal chelator activity, hepatoprotective activity, anti-inflammatory effects (8) anxiolytic potential (14) .…”

Section: Introductionmentioning

confidence: 99%

Alcohol extract of Tribulus terrestris ameliorates liver of mice exposed to cadmium acetate

Farhan¹

2019

JUAPS

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Background: Tribulus terrestris is known as food supplements and therapeutic agent. Objective: This study was presented to evaluate antitoxicity of fruit alcohol extracted from Tribulus terrestris to be used against heavy metal (cadmium) in female of albino mice.Methods: Twenty mice were examined in this experiment, and they were divided into three groups. The first group was a control group, while the second group was quaffed cadmium 6mg/kg, and third group was quaffed cadmium 6mg/kg and fruit alcohol extract of Tribulus terrestris 200mg/kg for ten days. Histological change was studied in the livers of these mice.Results: The histological sections of the liver in the mice exposed to cadmium have shown inflammation and necrosis in hepatocytes around central vein. Moreover, the liver was also hypertrophy, karyomegaly and increases glycogenesis. The results of the cadmium-exposed mice treated with the extract of Tribulus terrestris showed that the damage in the liver was slight. It showed normal cell shape and hepatic plate. It also showed simple inflammation and hypertrophy in a small space.Conclusion: The fruits of Tribulus terrestris can remove toxicity, protect our bodies (especially liver) against heavy metal such as cadmium.

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Section: Introductionmentioning

confidence: 99%

Alcohol extract of Tribulus terrestris ameliorates liver of mice exposed to cadmium acetate

Farhan¹

2019

JUAPS

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A Review on Therapeutic Effects of Tribulus terrestris

ناصری¹,

بزم²,

خزاعی³

2019

J. Med. Plants

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Anxiolytic and Antidepressant Effects of Tribulus terrestris Ethanolic Extract in Scopolamine-Induced Amnesia in Zebrafish: Supported by Molecular Docking Investigation Targeting Monoamine Oxidase A

Bouabdallah,

Ibrahim,

Brinza

et al. 2024

Pharmaceuticals

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Plants of the genus Tribulus have been used in folk medicine for wound healing, alleviating liver, stomach, and rheumatism pains, and as cognitive enhancers, sedatives, antiseptics, tonics, and stimulants. The present work aimed to evaluate whether Tribulus terrestris (Tt) administered for 15 days attenuated cognitive deficits and exhibited anxiolytic and antidepressant profiles in scopolamine-induced amnesia in zebrafish. Animals were randomly divided into six groups (eight animals per group): (1)–(3) Tt treatment groups (1, 3 and 6 mg/L), (4) control, (5) scopolamine (SCOP, 0.7 mg/kg), and (6) galantamine (Gal, 1 mg/L). Exposure to SCOP (100 µM) resulted in anxiety in zebrafish, as assessed by the novel tank diving test (NTT) and novel approach test (NAT). When zebrafish were given SCOP and simultaneously given Tt (1, 3, and 6 mg/L once daily for 10 days), the deficits were averted. Molecular interactions of chemical compounds from the Tt fractions with the monoamine oxidase A (MAO-A) were investigated via molecular docking experiments. Using behavioral experiments, we showed that administration of Tt induces significant anxiolytic-antidepressant-like effects in SCOP-treated zebrafish. Our result indicated that flavonoids of Tt, namely kaempferol, quercetin, luteolin, apigetrin, and epigallocatechin, could act as promising phytopharmaceuticals for improving anxiety-related disorders.

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Anxiolytic activity of ethanolic extract of aerial parts of Tribulus terrestris in mice

Cited by 4 publications

References 11 publications

Alcohol extract of Tribulus terrestris ameliorates liver of mice exposed to cadmium acetate

Alcohol extract of Tribulus terrestris ameliorates liver of mice exposed to cadmium acetate

A Review on Therapeutic Effects of Tribulus terrestris

Anxiolytic and Antidepressant Effects of Tribulus terrestris Ethanolic Extract in Scopolamine-Induced Amnesia in Zebrafish: Supported by Molecular Docking Investigation Targeting Monoamine Oxidase A

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