Anxiolytic and antidepressant activities of <scp><i>Pelargonium roseum</i></scp> essential oil on Swiss albino mice: Possible involvement of serotonergic transmission

Tabari, Mohaddeseh Abouhosseini; Moghaddam, Akbar Hajizadeh; Maggi, Filippo; Benelli, Giovanni

doi:10.1002/ptr.6038

Cited by 32 publications

(19 citation statements)

References 40 publications

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“…Moreover, WAY100635, a 5-HT receptor antagonist, blocks the action of the essential oil of lavender while the use of antagonists of GABA-A receptor is devoid of effect [42, 43]. Similar data are also achieved by Galdino et al and by Tabari et al who have observed anxiolytic effects after systemic injection of Spiranthera odoratissima and Rose geranium essential oils counteracted by pretreatment with 5-HT1A receptor antagonists but not by FLZ [44, 45].…”

Section: Discussionmentioning

confidence: 68%

Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats

Rombolà

Scuteri

Adornetto

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Anxiety disorders are one of the most common mental disorders, and benzodiazepines (BDZs), acting on gamma-aminobutyric acid type A (GABA-A) receptor complex, represent the most common antianxiety medications in the world. However, chronic BDZ use elicits several adverse reactions. Reportedly, aromatherapy is safer for the management of anxiety. Bergamot essential oil (BEO) extracted from Citrus bergamia Risso et Poiteau fruit, like other essential oils, is widely used in aromatherapy to relieve symptoms of stress-induced anxiety. Interestingly, preclinical data indicate that BEO induces anxiolytic-like/relaxant effects in animal behavioural tasks not superimposable to those of benzodiazepine diazepam. To better elucidate the involvement of GABAergic transmission, the present study examines the effects of pretreatment with flumazenil (FLZ), a benzodiazepine site antagonist, on BEO effects using open-field task (OFT) in rats. The data yielded show that FLZ does not significantly affect behavioural effects of the phytocomplex. These results demonstrate the lack of overlapping between BEO and BDZ behavioural effects, contributing to the characterization of the neurobiological profile of the essential oil for its rational use in aromatherapy.

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Section: Discussionmentioning

confidence: 68%

Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats

Rombolà

Scuteri

Adornetto

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Complementary and alternative therapies may play an important role in the clinical treatment of anxiety disorders (Hazim et al, 2014; Thorn et al, 2016). Compared to classical anxiolytic drugs, use of complementary and alternative medicine could show fewer side-effects (Li et al, 2016; Abouhosseini Tabari et al, 2018). The Gan-Mai-Da-Zao (GMDZ) decoction is one of the most famous herbal prescriptions in Chinese medical book Jin Gui Yao Lue (Medical Treasures of the Golden Chamber), which is written by medical sage Zhang Zhongjing (Ruan, 2003).…”

Section: Introductionmentioning

confidence: 99%

GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction

Chen

Yang

et al. 2019

Front. Neurosci.

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The Gan-Mai-Da-Zao (GMDZ) decoction is one of the most famous Chinese medicine prescriptions to treat emotional diseases in China. Here we examined the anxiolytic-like effects of the GMDZ decoction in mice. The mice were orally administered with GMDZ decoction (1, 2, and 4 g/kg, respectively) for 7 days, diazepam (2 mg/kg, p.o.) and buspirone (5 mg/kg, p.o.) were used as positive controls. Then, elevated plus maze (EPM) test, light/dark box (LDB) test, and marble burying (MB) test, open field (OF) test and rota-rod test were performed. We found that GMDZ treatment (2 and 4 g/kg) significantly increased the percentage of open arm entries and time spent on the open arms in EPM as compared to the control. GMDZ treatment also significantly increased the time spent in the light box and the number of light box entries in LDB and reduced the number of marbles buried in MB. Similarly to those observed with diazepam and buspirone. In contrast, GMDZ did not affect the locomotor activity in the OF and motor coordination in the rota-rod test. Furthermore, the anxiolytic-like effects induced by GMDZ were inhibited by the γ-aminobutyric acid-A (GABAA) receptor antagonist flumazenil and 5-hydroxytryptamine-1A (5-HT1A) receptor antagonist WAY-100635. These results showed that GMDZ possesses anxiolytic-like effects in animal models, and its mechanism of action might be modulated by 5-HT1A and GABAA receptors.

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“…This result is confirmed by a study of Pelargonium roseum essential oil, which contains monoterpenes, and is similar to the essential oil of Lippia sidoides Cham. The locomotor activity of the animals did not change, which also demonstrates its antidepressant effect [47].…”

Section: Discussionmentioning

confidence: 76%

Antidepressant-Like Effect of Lippia sidoides CHAM (Verbenaceae) Essential Oil and Its Major Compound Thymol in Mice

et al. 2018

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Depression is a common disease affecting more than 300 million people worldwide. Since has shown central nervous system effects in previous works, we aimed to investigate the effect of essential oil and its major compound, thymol on a corticosterone-induced depression model in mice. Male mice (20⁻25 g) received corticosterone (20 mg/kg, subcutaneously), once a day for 22 days. From the 16th day on, mice were grouped to receive either corticosterone or essential oil (100 and 200 mg/kg), or thymol (25 and 50 mg/kg) or fluoxetine (35 mg/kg) by gavage. The forced swimming test, tail suspension, open field, elevated plus maze and sucrose preference tests were performed from the 19th to 22nd day. Data were analyzed by ANOVA followed by the Student-Newman-Keuls as a post hoc test and the results were considered significant when < 0.05. It was shown that essential oil, thymol and fluoxetine decreased the immobility time in the tail suspension and forced swimming tests and none of these altered locomotor activity in the open field test. However, the drugs increased the amount of grooming. In the elevated plus maze, all drugs increased the number of entries and the time of permanence in the open arms. In the sucrose preference test, the essential oil, thymol and fluoxetine reversed anhedonia. These results suggest that the thymol and essential oil have an antidepressant-like effect, similar to fluoxetine. However, future studies should be encouraged to enhance understanding of the effects of essential oil and thymol for the treatment of depression.

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Anxiolytic and antidepressant activities of Pelargonium roseum essential oil on Swiss albino mice: Possible involvement of serotonergic transmission

Cited by 32 publications

References 40 publications

Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats

Anxiolytic-Like Effects of Bergamot Essential Oil Are Insensitive to Flumazenil in Rats

GABA and 5-HT Systems Are Involved in the Anxiolytic Effect of Gan-Mai-Da-Zao Decoction

Antidepressant-Like Effect of Lippia sidoides CHAM (Verbenaceae) Essential Oil and Its Major Compound Thymol in Mice

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