Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine

Toriizuka, Kazuo; Kamiki, Hiroko; Ohmura, Noriko Yosikawa; Fujii, Mikio; Hori, Yumiko; Fukumura, Motonori; Hirai, Yasuaki; Isoda, Susumu; Nemoto, Yukio; Ida, Yositeru

doi:10.1016/j.lfs.2004.12.054

Cited by 61 publications

(41 citation statements)

References 24 publications

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“…Thus, Cl -influx by G. jasminoides extract and geniposide played a role in their anxiolytic activity, as suggested by other reports (Toriizuka et al, 2005).…”

Section: Discussionsupporting

confidence: 66%

“…The fruit of G. jasminoides is widely employed in the treatment of inflammation, hypertension, jaundice, headache, edema and hepatic disorders (Koo et al, 2004;Shin et al, 2003). Geniposide and genipin are the major iridoid glycoside compounds existing in the fruit of gardenia and are responsible for its pharmacological activities such as hepatoprotective (Cgang, 1988), antithrombotic (Suzuki et al, 2001), neuroprotective (Sakura et al, 2001), neuritogenic (Yamazaki et al, 1996) and anti-inflammatory effects (Koo et al, 2004) and protective activity against oxidative damage (Okada et al, 2007), Oral administration of the water extracts of Gardeniae fructus and geniposide increased social interaction time in mice (Toriizuka et al, 2005). These results indicate that Gardeniae fructus and geniposide may exhibit anxiolytic activity.…”

Section: Introductionmentioning

confidence: 99%

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Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

Choi¹,

Peña²,

Choi³

et al. 2008

Biomolecules and Therapeutics

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− Gardenia jasminoides (G. jasminoides) is traditionally used to treat insomnia, jaundice, emotional disorders, hepatic disease, and inflammatory disease. Previously, we found that geniposide and the water extract of G. jasminoides increased Cl -influx in neuroblastoma. Here we examined the psychopharmacological activities of G. jasminoides and its constituents. G. jasminoides extract was orally administered at 100 and 200 mg/kg, and genipin and geniposide were intraperitoneally injected at 2, 10, and 20 mg/kg. Electroshock stress decreased open arm activity, but the extract and geniposide (20 mg/kg) significantly reversed that effect. This results indicate that G. jasminoides extract and geniposide alleviated anxiety with greater efficacy in stressed animals than normal animals.

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“…Thus, Cl -influx by G. jasminoides extract and geniposide played a role in their anxiolytic activity, as suggested by other reports (Toriizuka et al, 2005).…”

Section: Discussionsupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

Choi¹,

Peña²,

Choi³

et al. 2008

Biomolecules and Therapeutics

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“…piperascens), Angelicae Gigantis Radix (Angelica gigas Nakai), Glycyrrhizae Radix et Rhi-DOI: 10.1159/000489455 zoma (Glycyrrhiza uralensis Fischer), Moutan Cortex Radicis (Paeonia suffruticosa Andrews), Poria Cocos (Polypori umbellati Polyporaceae), Gardeniae Fructus (Gardenia jasminoides Ellis), and Paeoniae Radix (Paeonia lactiflora Pallas) [1]. GSS has been used to treat various symptoms and diseases, including psychological symptoms such as anxiety, irritability, and depression [2][3][4], sleep disturbances, headache, dizziness in postmenopausal women and depressive symptoms in premenstrual dysphoric disorder [5,6], chronic hepatic injury [7], and inflammatory diseases [8]. It is also used to treat abnormal gastric motility with functional dyspepsia [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Shin

Kim

et al. 2018

Digestion

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Background: Gamisoyo-San decoction (GSS), a traditional Chinese medicine, has been used to treat various gastrointestinal (GI) symptoms and diseases such as functional dyspepsia. The purpose of this study was to investigate the effect of GSS on GI motility functions in mice. Methods: Percent intestinal transit rate (ITR%) and gastric emptying (GE) values were measured using Evans Blue and phenol red, respectively, in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). Results: In normal mice, GSS (0.01–1 g/kg) induced higher GE values than non-treated controls. Also, GSS could increase GE in loperamide-induced and cisplatin-induced GE delay models. In addition, GSS increased ITR% in a dose-dependent manner. Loperamide decreased ITR% and GSS recovered this loperamide-induced decrease in ITR%. To examine the effect of GSS on GMD, we used acetic acid (AA)-induced and streptozotocin (STZ)-induced mouse GMD models. The AA mouse model showed a significant decrease in ITR%. However, intragastric treatment with GSS significantly recovered this inhibition. Furthermore, STZ-induced diabetic mice showed a significant reduction in ITR%, which was also significantly inhibited by GSS. Conclusion: These results demonstrate that GSS can modulate bowel activity and that it could be used as a gastroprokinetic agent in the treatment of GI motility diseases.

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“…35) Toriizuka et al reported that Menthae Herba, a component of Soyosan, increased the social interaction behavior in mice, indicating an anxiolytic effect. 36) Paeoliae Radix Alba is reported to influence the processes related to the mechanism of antidepressant action. 37) These findings show that Soyo-san acts on the central nervous system.…”

Section: Discussionmentioning

confidence: 99%

Antidepressant Effects of Soyo-san on Immobilization Stress in Ovariectomized Female Rats

Kim

Park

et al. 2007

Biological & Pharmaceutical Bulletin

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Depressive disorders are among the most frequently occurring psychiatric diseases, and are prevalent in at least 15% of the population. However, the prevalence of depressive disorders is twice as high in women as in men.1) The higher incidence and severity of depression is associated with the presence or absence of ovarian hormones.2) The ovarian hormones related to the menopause-induced depression influence the hippocampal anatomy and physiology; thus, they affect behavior in adult female rats. [3][4][5] The hippocampus plays an important role in the negative feedback mechanism of the limbic-hypothalamic-pituitary adrenal (LHPA) axis. It expresses high levels of adrenal steroid receptors and is especially susceptible to damage as a result of stress. 6,7) In the hippocampus, stress hormones induce regression of the dendritic processes and cell death, inhibit neurogenesis, and impair the ability of neurons to survive noxious stimuli such as seizure, hypoxia-ischemia, metabolic poisons, hypoglycemia and oxygen radical generators.8) The damage caused by a heightened stress response resulting from dysregulation of the LHPA axis is hypothesized to play a role in the reduced hippocampal volume often associated with major depression.9,10) Several neurotransmitter systems implicated in the regulation of the HPA axis have been hypothesized to be dysfunctional in major depression, including acetylcholine (ACh), norepnephrine, serotonin and dopamine.11) The central cholinergic neurons are of putative relevance to major depression. 12)Soyo-san consists of 9 kinds of medicinal herbs: Paeoliae Radix Alba, Atractylodis Macrocephalae Rhizoma, Angelicae Gigantis Radix, Poria, Liriopis Tuber, Bupleuri Radix, Menthae Herba, Glycyrrhizae Radix and Zingiberis Rhizoma Recens. Soyo-san is a traditional oriental herbal medicine, and it has been used in the treatment of mental stress, hypochondriac distensive pain, hysteria and manic-depressive illness. The various findings of recent preclinical studies have supported the therapeutic value of Soyo-san in a clinical setting. 13,14) In laboratory studies of animals, Soyo-san has also been shown to have antidepressive-like effects when using the tail suspension and forced swimming tests. 15,16) In animal models, it was suggested that exposure to uncontrollable and stressful life events led to a feeling of 'loss of control' which ultimately led to depression. In this 'learned helplessness' response, animals exposed to stressors have impaired performance in learning and memory.17)The aim of the present study was to explore the behavioral and the neurobiological effects of Soyo-san on ovariectomized female rats and to form a basis for clinical treatment. Soya-san's antidepressant effect was tested via a Morris water maze (MWM) and an elevated pulse maze (EPM), and we measured the serum corticosterone and immunohistochemical changes of acetylcholine in the brain. MATERIALS AND METHODSPreparation of Drug Soyo-san was prepared by mixing the 9 crude drugs in the same ratio (Table 1). It was provi...

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Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine

Cited by 61 publications

References 24 publications

Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

Psychopharmacological Profile of the Water Extract of Gardenia jasminoides and Its Constituents, Genipin and Geniposide, in Mice

Effects of Gamisoyo-San Decoction, a Traditional Chinese Medicine, on Gastrointestinal Motility

Antidepressant Effects of Soyo-san on Immobilization Stress in Ovariectomized Female Rats

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