Anxiolytic Effect of Natural Galphimines from <i>Galphimia glauca</i> and their Chemical Derivatives

Ruiz, Maribel Lucila Herrera; González-Cortazar, Manasés; Jiménez-Ferrer, Enrique; Zamilpa, Alejandro; Álvarez, Laura; Ramírez, Guillermo; Tortoriello, Jaime

doi:10.1021/np070583r

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, Herrera-Ruiz et al tested the anxiolytic properties of goldshower using the EPM test with different sets of mice. They found that the galphimine-rich fraction, galphimine A, and galphimine B showed a higher anxiolytic effect than the placebo, but this effect was modest compared to the standard drug [56]. These same authors [57] studied the effects of a standardized extract using the EPM, the light-dark test, and the forced swimming test in mice and observed an anxiolytic-like effect in the EPM and the light-dark tests; however, no effect was observed in the forced swimming test.…”

Section: Galphimia Glaucamentioning

confidence: 99%

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

2021

View full text Add to dashboard Cite

Sleep disorders are common among the general population and can generate health problems such as insomnia and anxiety. In addition to standard drugs and psychological interventions, there are different complementary plant-based therapies used to treat insomnia and anxiety. This review aimed to find and examine the most recent research on the use of herbal medicines for treating anxiety and insomnia as compiled from clinical trials, as well as to assess the safety and efficacy of these medicines and to elucidate their possible mechanisms of action. The process entailed a search of PubMed, Scopus, and the Cochrane Library databases from 2010 to 2020. The search terms included “sleep disorder”, “insomnia”, “sedative”, “hypnotic”, “anxiety”, “anxiolytic”, and “clinical trial”, combined with the search terms “herbs” and “medicinal plants”, in addition to individual herbal medicines by both their common and scientific names. This updated review, which focuses mainly on clinical trials, includes research on 23 medicinal plants and their combinations. Essential oils and their associations have also been reviewed. The efficacy of medicinal plants depends on treatment duration, types of study subjects, administration route, and treatment method. More clinical trials with an adequate, standardized design are necessary, as are more preclinical studies to continue studying the mechanisms of action. As a result of our work, we can conclude that the 3 plants with the most potential are valerian, passionflower, and ashwagandha, with the combination of valerian with hops and passionflower giving the best results in the clinical tests.

show abstract

Section: Galphimia Glaucamentioning

confidence: 99%

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

2021

View full text Add to dashboard Cite

show abstract

“…164,165 Galphimines have also been chemically modified via medicinal chemistry, furthering the understanding of some structure− activity relationships. 166 This general methodology (Figure 7) has been used since in several cases to identify bioactive compounds, and we will now highlight some very recent examples. Briefly, the first step is obtaining a sufficient number of samples, either by collecting samples from different locations, different plant parts, or closely related species, or by applying numerous, slightly different extraction steps.…”

Section: ■ Metabolomics For the Discovery Of Drugs From Natural Sourcesmentioning

confidence: 99%

Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine

et al. 2016

View full text Add to dashboard Cite

"Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at different levels, starting from the most fundamental, i.e., the genome, and finishing with the most functional, i.e., the metabolome. Similar to how genomics is applied to the exploration of DNA, metabolomics is the qualitative and quantitative study of metabolites. This emerging field is clearly linked to genomics, transcriptomics, and proteomics. In addition, metabolomics provides a unique and direct vision of the functional outcome of an organism's activities that are required for it to survive, grow, and respond to internal and external stimuli or stress, e.g., pathologies and drugs. The links between metabolic changes, patient phenotype, physiological and/or pathological status, and treatment are now well established and have opened a new area for the application of metabolomics in the drug discovery process and in personalized medicine.

show abstract

Mexican medicinal plants with anxiolytic or antidepressant activity: Focus on preclinical research

López‐Rubalcava

Estrada‐Camarena

2016

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Anxiolytic Effect of Natural Galphimines from Galphimia glauca and their Chemical Derivatives

Cited by 4 publications

References 0 publications

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

Medicinal Plants for Insomnia Related to Anxiety: An Updated Review

Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine

Mexican medicinal plants with anxiolytic or antidepressant activity: Focus on preclinical research

Contact Info

Product

Resources

About