Anxiolytic effects of prelimbic 5-HT1A receptor activation in the hemiparkinsonian rat

Serotonin6 receptors in the dorsal hippocampus regulate depressive-like behaviors in unilateral 6-hydroxydopamine-lesioned Parkinson's rats

“…In the present study, rats with unilateral lesions of the MFB showed decreased horizontal and vertical activity in the open field test when compared to sham-operated rats, indicating that DA depletion impairs locomotor activity of rats. These results are in agreement with previous reports (Eskow Jaunarajs et al, 2010;Zhang et al, 2011b;Delaville et al, 2012;Carvalho et al, 2013;Hui et al, 2014Hui et al, , 2015. In both sham-operated and the lesioned rats, intra-DH injection of WAY208466 or SB258585 did not affect locomotor activity as measured by the open field test, which is confirmed by previous studies Nikiforuk et al, 2011).…”

Activation of 5-HT1A receptors in the medial subdivision of the central nucleus of the amygdala produces anxiolytic effects in a rat model of Parkinson's disease

“…In the present study, unilateral 6-OHDA lesion of MFB significantly decreased the percents of entries and time spent in the open arms of EPM and the percent of time spent in the central area of OFT compared to sham-operated rats, indicating a increase of anxiety-like behavior after 6-OHDA lesion. The result is in good agreement with our previous report showing that rats with unilateral MFB lesions had increases of anxiety-like behaviors in the OFT and EPM tests (Hui et al, 2014).…”

“…The unilateral 6-OHDA lesions of the MFB in rats were performed as previously described (Hui et al, 2014). Rats were anesthetized with 4% chloral hydrate (400 mg/ kg, i.p.)…”

Associations among within-litter differences in early mothering received and later emotional behaviors, mothering, and cortical tryptophan hydroxylase-2 expression in female laboratory rats

“…Previous studies have found that the highest-licked males within a litter had lower serotonin transporter (SERT) expression in the midbrain compared to their low-licked brothers (Ragan et al, 2011), and that while long separations from the mother can increase TPH2 mRNA in the offspring dorsal raphe (Gardner et al, 2009) serotonin levels are decreased in brain areas related to emotional behavior (Daniels et al, 2004;Matthews et al, 2001;Matthews and Robbins, 2003). Based on studies of mPFC serotonin signaling and emotional behaviors in male rats (Hui et al, 2015;Pum et al, 2009;Solati et al, 2011), we had proposed that any relationship between development of the serotonin system and the amount of maternal care received would have consequences for similar behaviors in females.…”