Anxiolytic-like actions of reboxetine, venlafaxine and endurance swimming in stressed male rats

Lapmanee, Sarawut; Charoenphandhu, Narattaphol; Krishnamra, Nateetip; Charoenphandhu, Jantarima

doi:10.1016/j.bbr.2012.02.037

Cited by 29 publications

(14 citation statements)

References 49 publications

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“…Because chronic stress often alters brain monoamine levels (eg, NE) and consequently results in dysregulation of stress circuits, 41 the administration of drugs that block NE reuptake have been shown to have anxiolytic effects by directly influencing sympathetic nervous system function. 42 These preclinical models are supported by preliminary human studies 43,44 in PTSD, demonstrating that antidepressants with a noradrenergic mechanism of action may be effective in PTSD, particularly in addressing hypervigilance, although conclusive clinical trial results have not been reported to date.…”

Section: Discussionmentioning

confidence: 95%

Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus

et al. 2013

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Section: Discussionmentioning

confidence: 95%

Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus

et al. 2013

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“…Our recent investigation shows that restraint-stressed rats with anxiety-like or depression-like behaviors manifest a decrease in the expression of genes related to calcium absorption in the duodenal epithelial cells, which can be alleviated by an antidepressant drug, venlafaxine [6]. Interestingly, these restraint-stress-induced anxiety-and depression-like behaviors in rats appear to be effectively prevented by voluntary wheel running and endurance swimming [14,22]. Aerobic exercise similarly produces anti-psychological stress effects in humans [40].…”

Section: Discussionmentioning

confidence: 99%

“…In some experiments, Ovx rats were subjected to endurance swimming (non-impact exercise), followed by measurement of BMD and BMC. The voluntary wheel running and endurance swimming have been known to effectively reduce behavioral stress responses, including anxiety-and depression-like behaviors in rats [14,22]. At the end of the experiment, the dry heart weight normalized by the final body weight was determined to confirm the effectiveness of the endurance exercise protocols.…”

Section: Experimental Designmentioning

confidence: 99%

“…In addition, swimming is usually recommended for postmenopausal osteoporotic patients unable to perform weight-bearing exercise because they are overweight, have a joint injury, or are at risk of fracture [19]. Furthermore, since both wheel running and swimming are capable of protecting against stress, anxiety-like and depression-like behaviors in rodents [14,[20][21][22], one might postulate that both exercise modes should help alleviate osteopenia in stressed Ovx rats.…”

Section: Introductionmentioning

confidence: 99%

“…The swimming program was considered a non-weight bearing (non-impact) exercise with mean oxygen consumption of *63 mL/kg/min [22,25]. Each swimming rat was placed individually in a transparent cylindrical tank (80-cm height and 45-cm diameter) containing water at 30-32°C (44-cm deep).…”

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Voluntary wheel running mitigates the stress-induced bone loss in ovariectomized rats

et al. 2014

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In estrogen-deficient rodents with osteopenia, repetitive exposure to mild-to-moderate stress, which mimics the chronic aversive stimuli (CAS) of the modern urban lifestyle in postmenopausal women, has been hypothesized to cause the bone microstructure to further deteriorate. Recently, we have provided evidence in rats that voluntary impact exercise, e.g., wheel running, is as effective as pharmacological treatments for stress-induced anxiety and depression. The present study, therefore, aims to investigate whether a 4-week CAS exposure aggravates trabecular bone loss in ovariectomized (Ovx) rats, and whether CAS-induced bone loss can be rescued by voluntary wheel running. CAS was found to elevate the serum levels of corticosterone, a stress hormone from the adrenal gland. Dual energy X-ray absorptiometry revealed a decrease in bone mineral content (BMC) in the tibiae of CAS-exposed Ovx rats as compared to the CAS-free Ovx rats (control), while having no detectable effect on bone mineral density (BMD). Bone histomorphometric analysis of the proximal tibial metaphysis showed that CAS decreased trabecular bone volume and increased trabecular separation, which were completely restored to the baseline values of Ovx rats by voluntary wheel running. This CAS-induced trabecular bone loss in Ovx rats was probably due to an enhancement of osteoclast-mediated bone resorption, as indicated by increases in osteoclast surface and active erosion surface. Moreover, wheel running as well as non-impact exercise (endurance swimming) effectively increased the tibial BMD and BMC of CAS-exposed Ovx rats. It can be concluded that exercise is an effective intervention in mitigating CAS-induced bone loss in estrogen-deficient rats.

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The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies

Heesbeen,

van Kampen,

Verdouw

et al. 2024

Psychopharmacology

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Rationale Selective serotonin reuptake inhibitors (SSRIs) are the first choice of treatment for anxiety-like disorders. However, which aspects of anxiety are affected by SSRIs is not yet fully understood. Objective We aimed to systematically review the effect of six clinically effective SSRIs on four aspects of unconditioned anxiety: approach-avoidance behaviour (elevated plus maze), repetitive behaviour (marble burying), distress behaviour (ultrasonic vocalization), and activation of the autonomous nervous system (stress-induced hyperthermia). Methods We identified publications by searching Medline and Embase databases and assessed the risk of bias. A random effects meta-analysis was performed and moderator effects were analysed with Bayesian penalized meta-regression. Results Our search yielded 105 elevated plus maze, 63 marble burying, 11 ultrasonic vocalization, and 7 stress-induced hyperthermia articles. Meta-analysis suggested that SSRIs reduce anxiety-like behaviour in the elevated plus maze, marble burying and ultrasonic vocalization test and that effects are moderated by pre-existing stress conditions (elevated plus maze) and dose dependency (marble burying) but not by duration of treatment or type of SSRI. The reporting quality was low, publication bias was likely, and heterogeneity was high. Conclusion SSRIs seem to reduce a broad range of unconditioned anxiety-associated behaviours. These results should be interpreted with caution due to a high risk of bias, likely occurrence of publication bias, substantial heterogeneity and limited moderator data availability. Our review demonstrates the importance of including bias assessments when interpreting meta-analysis results. We further recommend improving the reporting quality, the conduct of animal research, and the publication of all results regardless of significance.

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Anxiolytic-like actions of reboxetine, venlafaxine and endurance swimming in stressed male rats

Cited by 29 publications

References 49 publications

Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus

Association of Posttraumatic Stress Disorder With Reduced In Vivo Norepinephrine Transporter Availability in the Locus Coeruleus

Voluntary wheel running mitigates the stress-induced bone loss in ovariectomized rats

The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies

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