Anxiolytic-like and sedative effects of Hydrocotyle umbellata L., Araliaceae, extract in mice

Rocha, Fábio Fagundes da; Almeida, Cláudio S.; Santos, Rafael T. dos; Santana, Suely A.; Costa, Élson Alves; Paula, José Realino de; Vanderlinde, Frederico Argollo

doi:10.1590/s0102-695x2011005000018

Cited by 16 publications

(8 citation statements)

References 23 publications

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“…Several plants inducing increasing exploration in open arms in the elevated plus-maze test are used to diminish anxiety in folk medicine. Among them Hydrocotyle umbellata (Rocha et al, 2011) and Aloysia polystachya (HellionIbarrola et al, 2005;Mora et al, 2005) were mentioned for South America. Furthermore, elevated plus-maze test is recognized as an useful tool to detect the effect of anxiolytic drugs (Hogg, 1996).…”

Section: Resultsmentioning

confidence: 99%

Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice

Hellión-Ibarrola¹,

Montalbetti²,

Heinichen³

et al. 2012

Rev. bras. farmacogn.

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Kyllinga brevifolia Rottb., Cyperaceae, rhizomes have been widely used in the Paraguayan folk medicine as digestive, diuretic, sedative, tonic, antispasmodic and sudorifi c. The purpose of this study is to characterize the putative sedative, anxiolytic effects of the crude hydro-ethanolic extract (CEKb) and fractions of the rhizome of K. brevifolia, in male mice. The behaviour of mice was assessed in the open fi eld, hole board, rota-rod and elevated plus-maze (EPM) test. Oral treatment with single doses of 10, 100 and 1000 mg/kg of CEKb and 10 mg/kg of ethyl acetate fraction (KbF-ethyl-ac) increased the duration of the sleeping time induced by pentobarbital. Oral administration of 1, 10 and 100 mg/kg of CEKb and 0.1, 1 and 10 mg/kg of KbFethyl-ac also signifi cantly increased the time-spent and arm entries into open arms of the elevated plus maze (EPM) versus control group. These fi ndings indicate that K. brevifolia exerts a weak sedative and an interesting anxiolytic-like effect in mice and suggest its potential usefulness for the treatment of anxiety in humans.

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Section: Resultsmentioning

confidence: 99%

Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice

Hellión-Ibarrola¹,

Montalbetti²,

Heinichen³

et al. 2012

Rev. bras. farmacogn.

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“…Upon reviewing the literature, it was found that CA is reported to exhibit same therapeutic effects as these 30 contemporary drugs. CA manifests anti-diabetic (Rahman et al, 2011;Emran et al, 2015), anti-ulcer (Sairam et al, 2001;Abdulla et al, 2010), anti-fungal (Lalitha et al, 2013), anti-cholinergic (Arora et al, 2018), anti-cancer (Hamid et al, 2016;Ren et al, 2016), anti-bacterial (Arumugam et al, 2011;Idris and Nadzir, 2017), anxiolytic (Wijeweea et al, 2006;Wanasuntronwong et al, 2012), anti-convulsant (Manasa and Sachin, 2016; Sudha et al, 2002), anti-inflammatory (Somchit et al, 2004;Chippada et al, 2011), anti-diarrheal (George et al, 2009), anti-psychotic (Chimbalkar et al, 2015;Chen et al, 2003), anti-nociceptive (Somchit et al, 2004;George et al, 2008), analgesic (Saha et al, 2013;Qureshi et al, 2015) and sedative (Hossain et al, 2005;Rocha et al, 2011) properties. Though it has been proved that CA possesses the aforesaid properties in various studies, the specific compounds or the mechanism of action responsible for all these properties are not known.…”

Section: The Contemporary Medicinesmentioning

confidence: 99%

Identification of annotated metabolites in the extract of Centella asiatica

Rani¹,

Tyagi²,

Singh³

et al. 2019

J. Med. Plants Res.

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Plants contribute to 75% of molecular medicines (MM) either directly or indirectly. Centella asiatica (CA) is being extensively used in experimental and clinical studies. However, its scientific approval is not forthcoming. It is well known that every plant contains useful as well as some harmful compounds. Subjecting whole plant extracts containing harmful compounds to modern pharmacological methods will only demonstrate that they are not safe for use as medicines. To ascertain both the useful and harmful compounds in CA extract, all the compounds of the extract must be identified. In the present study, a methanol extract was prepared from the whole plant. The compounds were identified using liquid chromatography-mass spectrometry with database confirmation. 3,201 compounds were identified using the METLIN database. Database searches yielded 1,187 biological compounds of which 154 were for human/human cell lines. These 154 compounds were classified based on their already reported effects. Two contemporary medicines found in this extract were quantified. Here, we report both beneficial and harmful compounds in the methanol extract of CA. We propose that the harmful compounds can be removed to yield safe medicines from CA.

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“…H. umbellata L. leaves in high doses produce emetic effects and are potentially toxic (Corrêa 1984, Reis et al 1992, Fischer et al 1994. Our previous study found that the ethanolic extract from H. umbellata L. showed anxiolytic-like and sedative effects in mice (Rocha et al 2011).…”

Section: Introductionmentioning

confidence: 95%

Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice

Florentino

Nascimento

Galdino

et al. 2013

An. Acad. Bras. Ciênc.

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The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.

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Anxiolytic-like and sedative effects of Hydrocotyle umbellata L., Araliaceae, extract in mice

Cited by 16 publications

References 23 publications

Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice

Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice

Identification of annotated metabolites in the extract of Centella asiatica

Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice

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