Anxiolytic-like effect of Azadirachta indica A. Juss. (Neem, Meliaceae) bark on adult zebrafish (Danio rerio): participation of the Serotoninergic and GABAergic systems

Silva, Antônio Wlisses da; Ferreira, Maria Kueirislene Amâncio; Rebouças, Emanuela L.; Silva, Francisca Crislândia O.; Holanda, Carlos Leone Alves

doi:10.15406/ppij.2020.08.00303

Cited by 7 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, Silva et al. [51] observed that the saponifiable fraction of the ethanolic extract of Azadirachta indica (Neem) bark showed anxiolytic-similar effect, since fish treated with this preparation (1.0 or 2.5 or 5.0 mg/mL; 20 µL; i.p .) remained most of the time of analysis in the clear zone, showing a significantly similar effect ( p <0.05) to Diazepam (2.5 mg/mL; 20 µL; i.p .…”

Section: Resultsmentioning

confidence: 96%

Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)

Souza

Pinheiro

Soares

et al. 2023

Fish and Shellfish Immunology Reports

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)

Souza

Pinheiro

Soares

et al. 2023

Fish and Shellfish Immunology Reports

View full text Add to dashboard Cite

“…It also inhibited the phosphorylation of IκB-α, NF-κB p65 and expression of TLR4 lipopolysaccharide treated mice Lung related complications Yunhe et al, 2012 Aqueous bark extract improved hippocampal ACH release and central serotonergic activity in rat and human model Mental Problem Nakazawa et al, 2003 Meliaceae Azadirachta indica A.Juss. Ethyl acetate fraction of bark improved sedative and anxiolytic effect on adult zebrafish through serotonergic and GABAergic systems due to its phenolic and flavonoid content Mental Problem Silva et al, 2020 Bark extract decreased rotational behavior condition and improved glutathione peroxidase, iNOS activity in 6-hydroxydopamine treated rat model Parkinsonism Xiang et al, 2018 Aqueous leaves extract showed protective effects against cigarette smoke, lipopolysaccharide induced pulmonary inflammation and improved infiltration of neutrophils and macrophages in bronchoalveolar lavage fluid Lung related complications Lee et al, 2017 Aqueous leaves extract improved renal injury in Plasmodium berghei treated renal injured mice Kidney complications Somsak et al, 2015 Aqueous leaf extract exhibited potent cardioprotective effect in isolated perfused frog and rabbit heart Cardiac complications Khosla et al, 2002 Aqueous leave extract reduced serum aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transpeptidase levels in paracetamol treated rat Liver related problem Bhanwra et al, 2000 Toona sinensis (Juss.)M. Roem.…”

Section: Herbal Formulae From Different Traditional Systems Of Medicinementioning

confidence: 99%

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

et al. 2022

View full text Add to dashboard Cite

Background : The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. Purpose : The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. Study design : Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. Methods : A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. Results : Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. Conclusion : K...

show abstract

“…Zebrafish (Danio rerio), a member of the Cyprinidae family, has a fully sequenced genome and shares 71 % of the genetic orthology and body plan similarity with humans [11]. Data previously reported in the literature indicate the use of zebrafish in nociception [12,13], orofacial nociception [14][15][16], inflammation [17], and anxiety models [18,19].…”

mentioning

confidence: 99%

Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)

et al. 2023

View full text Add to dashboard Cite

This study evaluates the pharmacological potential of cis-jasmone (CJ) in adult zebrafish (Danio rerio; aZF). Initially, aZF (n = 6/group) were pretreated (20 µL; p. o.) with CJ (0.1 or 0.3 or 1.0 mg/mL) or vehicle (0.5% Tween 80). The animals were submitted to acute toxicity and locomotion tests, pentylenetetrazole-induced seizure, carrageenan-induced abdominal edema, and cinnamaldehyde-, capsaicin-, menthol-, glutamate-, and acid saline-induced orofacial nociception. The possible mechanisms of anticonvulsant, anxiolytic, and antinociceptive action were evaluated. The involvement of central afferent fibers sensitive to cinnamaldehyde and capsaicin and the effect of CJ on the relative gene expression of TRPA1 and TRPV1 in the brain of aZF were also analyzed, in addition to the study of molecular docking between CJ and TRPA1, TRPV1 channels, and GABAA receptors. CJ did not alter the locomotor behavior and showed pharmacological potential in all tested models with no toxicity. The anticonvulsant effect of CJ was prevented by flumazenil (GABAergic antagonist). The anxiolytic-like effect of CJ was prevented by flumazenil and serotonergic antagonists. The antinociceptive effect was prevented by TRPA1 and TRPV1 antagonists. Chemical ablation with capsaicin and cinnamaldehyde prevented the orofacial antinociceptive effect of CJ. Molecular docking studies indicate that CJ interacted with TRPA1, TRPV1, and GABAA receptors. CJ inhibited the relative gene expression of TRPA1 and TRPV1. CJ has pharmacological potential for the treatment of seizures, anxiety, inflammation, and acute orofacial nociception. These effects are obtained by modulating the GABAergic and serotonergic systems, as well as the TRPs and ASIC channels.

show abstract

Anxiolytic-like effect of Azadirachta indica A. Juss. (Neem, Meliaceae) bark on adult zebrafish (Danio rerio): participation of the Serotoninergic and GABAergic systems

Cited by 7 publications

References 17 publications

Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)

Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)

Contact Info

Product

Resources

About