Anxiolytic potential of <i>Perseaamericana</i> M. by elevated plus maze test

Fernandes, Zeena; Khandige, Prasanna Shama; D’Souza, Ullas Prakash

doi:10.5958/0974-360x.2020.00590.9

Rese. Jour. of Pharm. and Technol.

2020

DOI: 10.5958/0974-360x.2020.00590.9

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Anxiolytic potential of Perseaamericana M. by elevated plus maze test

Zeena Fernandes¹,

Prasanna Shama Khandige²,

Ullas Prakash D’Souza³

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Cited by 3 publications

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Attenuation of Experimentally Induced Anxiety by Panchagavya Ghrita in Mice

Shetty

Joshi

2022

RJPT

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The present study was undertaken to evaluate the effect of Panchagavya ghrita on experimentally induced anxiety in swiss albino mice. The study was carried out with an objective of scientifically validating the traditional claims and to compare the ancient knowledge with the latest pharmacological aspects of preclinical research. The Swiss albino mice were divided into 4 groups of 6 mice each. First group received vehicle 10mg/kg orally. Second group was treated with the standard drug diazepam (2mg/kg i.p) one hour before the experiment. Third and fourth group animals were treated with the two different doses of Panchagavya ghrita i.e., 4680mg/kg p.o and 6840mg/kg p.o once daily for 14 days. On the 15th day one hour after administration of the test dose, anti anxiety activity was evaluated using Elevated Plus maze model, Light Dark Transition model & Open field test. Animals treated with Panchagavya Ghrita showed significant result by increasing the number of entries into the open arm and time spent in open arm in Elevated Plus maze model. In Light & Dark Transition model, it showed increase in the Number of entries into the light chamber and time spent in the light chamber and in the open field test, the number of rearings, time spent in the central square and the number of squares crossed increased thus proving the antianxiety activity of Panchagavya ghrita.

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Attenuation of Experimentally Induced Anxiety by Panchagavya Ghrita in Mice

Shetty

Joshi

2022

RJPT

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Evaluation of Zinc acetate in decreasing anxiety like behavior in Swiss Albino Mice using behavior model

2024

RJPT

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Anxiety disorder is one of the most commonly occurring mental health conditions with less visibility leading to profound disability. Zinc, one of the most ubiquitous trace elements, has been identified to interact with the glutamate and GABAA receptors. This study was conducted to assess the anxiolytic activity of zinc acetate using a various behavioural model. Swiss albino mice were used in this study. The mice were randomised into 5 groups and were treated with control- normal saline, Diazepam as a standard drug, zinc acetate (10 and 20mg/kg) and zinc acetate 10mg/kg + Diazepam. Their anxiety like behaviour was assessed using elevated plus maze. In the elevated plus maze, zinc acetate at 20mg/kg and zinc acetate 10mg/kg + Diazepam showed increased amount of time spent in the open arm and also the number of entries into the open arm. Statistical analysis was performed using unpaired t- test. In conclusion, zinc acetate decreases anxiety like behaviour in mice and also potentiates the action of Diazepam.

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A Review on the Role of some Cardioprotective Natural Resources in Mitigating Doxorubicin-Induced Cardiotoxicity

Pal,

Subhra Saha,

Dey

et al. 2024

RJPT

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As an effective and widely used anti-cancer medication, doxorubicin (DOX) also has the side effect of causing dose-dependent organ toxicity, primarily cardiotoxicity. Recent research has shown that the main pathogenic factors causing cardiomyopathy are oxidative stress, inflammation, and consequent cardiomyocyte death. Due to the shortcomings of currently available adjuvants in terms of pharmacoeconomics, short-term efficacy, and inherent adverse effects, the clinical application of classical cytotoxic medicines continues to be a preferred mode of treatment for cancer. As anticancer, chemopreventive, and cardioprotective agents, numerous dietary plants and mushrooms of natural origin have recently attracted interest. The current analysis provides an overview ofthe cardioprotective effect of some naturally occurring resources against experimental model-induced cardiotoxicity caused by DOX. Additionally, the review article covers the geographical availability, biological source, chemical constituents, and pharmacological actions associated with the pharmaceutical development of natural resources and their prospective application for additional drug development. These substances could be a valuable source of alternative adjuvants for chemotherapy used in medication development that are optimal, affordable, and safe.

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Anxiolytic potential of Perseaamericana M. by elevated plus maze test

Cited by 3 publications

References 0 publications

Attenuation of Experimentally Induced Anxiety by Panchagavya Ghrita in Mice

Attenuation of Experimentally Induced Anxiety by Panchagavya Ghrita in Mice

Evaluation of Zinc acetate in decreasing anxiety like behavior in Swiss Albino Mice using behavior model

A Review on the Role of some Cardioprotective Natural Resources in Mitigating Doxorubicin-Induced Cardiotoxicity

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