Aortic aneurysm

Mathur, Atul; Mohan, Vinay; Ameta, Deepak; Gaurav, Bhardwaj; Haranahalli, Pradeep

doi:10.1515/jtim-2016-0008

Cited by 71 publications

(54 citation statements)

References 43 publications

(37 reference statements)

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“…Aortic aneurysm (AA) represents an important cause of death. AA is clinically characterized by an enlargement of at least 50% of an aortic segment compared with the same segment in healthy individuals and can be subdivided in thoracic aortic aneurysm (TAA) or abdominal aortic aneurysm (AAA), the latter being the most frequent [42]. AA is accompanied by progressive degeneration of the aortic wall [42].…”

Section: Aortic Aneurysmmentioning

confidence: 99%

“…AA is clinically characterized by an enlargement of at least 50% of an aortic segment compared with the same segment in healthy individuals and can be subdivided in thoracic aortic aneurysm (TAA) or abdominal aortic aneurysm (AAA), the latter being the most frequent [42]. AA is accompanied by progressive degeneration of the aortic wall [42]. Initially, a bulge-like dilation of a segment of the aortic wall tends to expand and increase the risk of rupture [42].…”

Section: Aortic Aneurysmmentioning

confidence: 99%

“…AA is accompanied by progressive degeneration of the aortic wall [42]. Initially, a bulge-like dilation of a segment of the aortic wall tends to expand and increase the risk of rupture [42].…”

Section: Aortic Aneurysmmentioning

confidence: 99%

See 2 more Smart Citations

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Videira

Martins

Falcão-Pires

2020

IJMS

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In 2020, cardiovascular diseases (CVDs) remain a leading cause of mortality and morbidity, contributing to the burden of the already overloaded health system. Late or incorrect diagnosis of patients with CVDs compromises treatment efficiency and patient’s outcome. Diagnosis of CVDs could be facilitated by detection of blood-based biomarkers that reliably reflect the current condition of the heart. In the last decade, non-coding RNAs (ncRNAs) present on human biofluids including serum, plasma, and blood have been reported as potential biomarkers for CVDs. This paper reviews recent studies that focus on the use of ncRNAs as biomarkers of CVDs.

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Section: Aortic Aneurysmmentioning

confidence: 99%

Section: Aortic Aneurysmmentioning

confidence: 99%

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Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Videira

Martins

Falcão-Pires

2020

IJMS

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“…Thoracic aortic aneurysms affect all three layers of the vessel and is applicable to any dilatation of over 1.5 times its normal size anywhere from the aortic root to the beginning of abdominal aorta (4,5). TAAs most commonly affect the aortic root and ascending aorta (60%) but can also affect other segments such as descending aorta (35%) and aortic arch (<10%) (6). Despite being similar pathologies and sharing some aetiologies, such as connective tissue degeneration and biomechanical changes, TAA distinguishes itself from the signature inflammatory changes in abdominal aortic aneurysms (AAAs) with its heavier genetic involvements (5,7).…”

Section: Introductionmentioning

confidence: 99%

The genetics and biomechanics of thoracic aortic diseases

Harky

Fan

2019

Vascular Biology

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Thoracic aortic aneurysms and aortic dissections (TAAD) are highly fatal emergencies within cardiothoracic surgery. With increasing age, thoracic aneurysms become more prevalent and pose an even greater threat when they develop into aortic dissections. Both diseases are multifactorial and are influenced by a multitude of physiological and biomechanical processes. Structural stability of aorta can be disrupted by genes, such as those for extracellular matrix and contractile protein, as well as telomere dysfunction, which leads to senescence of smooth muscle and endothelial cells. Biomechanical changes such as increased luminal pressure imposed by hypertension are also very prevalent and lead to structural instability. Furthermore, ageing is associated with a pro-inflammatory state that exacerbates degeneration of vessel wall, facilitating the development of both aortic aneurysms and aortic dissection. This literature review provides an overview of the aetiology and pathophysiology of both thoracic aneurysms and aortic dissections. With an improved understanding, new therapeutic targets may eventually be identified to facilitate treatment and prevention of these diseases.

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“…населення на рік і переважно (≈ 60 %) локалізується в корені аорти або висхідному відділі аорти. Аневризма кореня аорти часто спричинює аортальну недостатність, при збереженій морфологічній структурі стулок аортального клапана [1]. Клапанозберігаюча операція для пацієнтів з аневризмою кореня аорти була запропонована Тайроном Девідом в 1992 році, на противагу протезуванню кореня аорти штучним клапаном, і дала змогу зберегти пацієнтам нативний аортальний клапан.…”

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Valve-Sparing Operation in Patients with Aortic Root Aneurysm

Tsvyk¹,

Dovgan²,

Varbanets³

et al. 2020

ujcvs

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Background. Aortic root aneurysm is rare but life-threatening disease which affects not only aortic wall, but aortic valve as well. Valve-sparing operation was developed by Tirone David and gave a chance to save native aortic valve in patients with aortic root aneurysm and to avoid aortic valve replacement. The aim. To analyze postoperative results and complications after aortic valve-sparing operation in patients with aortic root aneurysm. Materials and methods. Sixteen patients with aortic root aneurysm were operated at the Ukrainian Children’s Cardiac Center (UCCC) during the period from 2012 to 2018. The patients underwent aortic root reimplantation. Results. Postoperative results were analyzed in 100% cases. Mean postoperative follow-up period was 25.6 ± 13.3 months. Total mortality was 0%. No patients required re-operation due to aortic aneurysm or that on aortic valve. Conclusions. Collected data indicates that aortic root reimplantation is the procedure which can be chosen both for young and old patients. This is the procedure with lower risks and mortality comparing to aortic root replacement. It gives chance to preserve native aortic valve and its adequate functioning. Postoperative observation results indicate long-term freedom from reoperation due to aortic aneurysm and aortic valve insufficiency. This procedure is equally efficient in patients with either tricuspid or bicuspid aortic valve and can be efficiently implemented in patients with Marfan syndrome.

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Aortic aneurysm

Cited by 71 publications

References 43 publications

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

Non-Coding RNAs as Blood-Based Biomarkers in Cardiovascular Disease

The genetics and biomechanics of thoracic aortic diseases

Valve-Sparing Operation in Patients with Aortic Root Aneurysm

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