“…Such changes have been attributed to the hypoxic-ischaemic injury and the vulnerability of the neonatal blood-brain barrier, cerebral white matter and germinal matrix [10]. Selective antegrade cerebral perfusion (SCP) has been employed to provide cerebral blood flow during HCA in aortic arch operations for adults as well as neonates [11,12,17]. While SCP theoretically affords some degree of neuroprotection to the patient, there are limited data to substantiate this claim [2,3,9,14,15].…”