Aortic stenosis in the elderly can be prevented: old risk factors and a new pathological condition

Niclosamide Inhibits Aortic Valve Interstitial Cell Calcification by Interfering with the GSK-3β/β-Catenin Signaling Pathway

“…CAVS is a slowly progressive disorder for which no effective medical therapy has been developed to date ( Hutcheson et al ., 2014 ; Pasquale et al ., 2019 ). With valve replacement as the only treatment option, developing a novel therapeutic strategy is deemed critical, which necessitates a thorough understanding of the molecular mechanisms involved in CAVS pathobiology ( Rutkovskiy et al ., 2017 ).…”

The effects of geriatric aortic stenosis education and its implications on heart failure prevention in medically underserved communities

“…Given our progressively aging population, aortic stenosis has become the most common cause of valvular heart disease, affecting 12.4% of people >75 years of age, with no consistent means of prevention. 1–3 Age-related aortic stenosis usually begins after the age of 60 with gradual calcification of the aortic valve that obstructs the left ventricular outflow tract of the heart, resulting in a pressure overload that, if left untreated, leads to heart failure. 1,4 Severe aortic stenosis has the capability of quickly escalating to a poor prognosis, with a mortality rate as high as 50% at one year.…”

“…1–3 Age-related aortic stenosis usually begins after the age of 60 with gradual calcification of the aortic valve that obstructs the left ventricular outflow tract of the heart, resulting in a pressure overload that, if left untreated, leads to heart failure. 1,4 Severe aortic stenosis has the capability of quickly escalating to a poor prognosis, with a mortality rate as high as 50% at one year. 1 The presentation of aortic stenosis can be challenging owing to the high frequency of low gradient severe aortic stenosis, meaning patients may present without any symptoms until the acute-onset of heart failure.…”

“…1,4 Severe aortic stenosis has the capability of quickly escalating to a poor prognosis, with a mortality rate as high as 50% at one year. 1 The presentation of aortic stenosis can be challenging owing to the high frequency of low gradient severe aortic stenosis, meaning patients may present without any symptoms until the acute-onset of heart failure. 5 Previous research focused directly on aortic stenosis prevention, such as lowering serum levels of calcium or phosphate, but this association has been inconsistent.…”