Aortic stiffness in young patients with heterozygous familial hypercholesterolemia

Pitsavos, Christos; Toutouzas, Konstantinos; Dernellis, John; Skoumas, John; Skoumbourdis, E.; Stefanadis, Christodoulos; Toutouzas, Pavlos

doi:10.1016/s0002-8703(98)70274-1

Cited by 126 publications

(114 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11,[15][16][17][35][36][37] Of these CAD risk factors, sex and the number of patients with hypertension and smoking habit were different between our groups. However, the findings were tested after adjustment for all CAD risk factors, considering their possible effects.…”

Section: Discussionmentioning

confidence: 99%

“…Secondly, do the aortic CDTI measurements really indicate changes in the elastic properties of the aorta? For this purpose, aortic stiffness and distensibility were studied with a method accepted in the literature 11) and their relationship with the direct measurements made by CTDI. In our study, the aortic stiffness was increased, and the aortic S, E and A velocities were decreased in the group with CAD.…”

Section: Discussionmentioning

confidence: 99%

“…It was for this reason that the velocity of transmission of the pulse wave was used as a clinical index of arterial elasticity by Bramwell and Hill in 1922, 6) and then by a large number of authors using different methods. [7][8][9] Today, calculation of pulse wave velocity 10) and aortic stiffness index 11) are commonly being used as noninvasive methods. These methods are not without drawbacks since they are indirect to a certain extent.…”

mentioning

confidence: 99%

See 2 more Smart Citations

<b>Color Doppler Tissue Imaging in Assessing the Elastic Properties of the Aorta and in Predicting Coronary Artery Disease</b>

et al. 2002

View full text Add to dashboard Cite

SUMMARYWe hypothesized that the change in aortic elastic properties could directly be shown with color Doppler tissue imaging (CDTI), that these findings could be related to aortic stiffness and distensibility and that, through these, coronary artery disease (CAD) could be predicted.One hundred and twenty six patients (group I: 83 with CAD, mean age 54±10 years, 18 female, 65 male; group II: 43 without CAD, mean age 53±10 years, 27 female, 16 male) having been evaluated for coronary artery disease by angiography were examined by echocardiography. Arterial pressure was measured immediately before echocardiographic evaluation. Internal aortic systolic and diastolic diameters by M-mode echocardiography and aortic upper wall tissue velocities (Aortic S, E, A, m/sec) by CDTI were measured 3 cm above the aortic valve. Lateral mitral annulus tissue velocities (Annulus S, E, A, m/sec) were also recorded. Aortic distensibility (cm 2 •dynes -1 ) and aortic stiffness index were calculated using formulas. In the statistical analyses, CAD risk factors and left ventricular ejection fraction were used for adjustment.Aortic stiffness (2.79±3.49 vs 1.62±1.31, P=0.03), distensibility (1.55±1.46 vs 2.37±3.08, P=0.04), and aortic S velocity (0.057±0.016 vs 0.064±0.015, P=0.02) differed significantly between groups I and II. After adjustment, while aortic stiffness and S velocity were still statistically different (P=0.04; P=0.03 respectively), the significance of the difference in aortic distensibility disappeared (P=0.051). Aortic stiffness and aortic S velocity (0.06 m/sec<) were important CAD determinants (Odds ratio=1.4 P=0.03; Odds ratio=3.6 P=0.01, respectively), but aortic distensibility was not. Aortic stiffness was correlated only with aortic S velocity (r=-0.28, P=0.01), and aortic distensibility had a significantly positive correlation with aortic S velocity (r= 0.20, P=0.02). The interobserver and intraobserver correlation coefficients for aortic S velocities were 0.65 and 0.71, respectively (P<0.05).Elastic properties of the aorta can directly be assessed by reproducibly measuring the movements in the upper wall of the aorta by CDTI. Reduced aortic S velocity is associFrom the

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

<b>Color Doppler Tissue Imaging in Assessing the Elastic Properties of the Aorta and in Predicting Coronary Artery Disease</b>

et al. 2002

View full text Add to dashboard Cite

show abstract

“…AoS was calculated using the formula AoS(%) ¼ 100 Â (AoDs-AoDd)/(AoDd), which has been validated by angiographic techniques in previous studies. 8,9 Flow velocity profiles were obtained using colour, pulsed and continuous wave Doppler from apical projections. The following indices were measured from the mitral valve diastolic wave form: isovolumic relaxation time (IVRT; ms), peak early (E) and atrial (A) flow velocities (cm/sec), E/A ratio (the ratio of the mitral inflow velocities), decceleration time (DT; ms) of the LV diastolic filling using standard methodology.…”

Section: Echocardiography and Dopplermentioning

confidence: 99%

“…[8][9][10] Studies in humans have shown that hypertension may result in arterial stiffening, increased pulse wave velocity and thus, to the early arrival of the reflected waves. [3][4][5][6][7] In experimental studies, the early arrival of the wave reflections causes augmentation of the central systolic and reduction of the diastolic aortic pressure leading to the impairment of coronary perfusion and left ventricular (LV) diastolic function.…”

Section: Introductionmentioning

confidence: 99%

Incremental value of arterial wave reflections in the determination of left ventricular diastolic dysfunction in untreated patients with essential hypertension

et al. 2008

View full text Add to dashboard Cite

Systemic arterial stiffness is an indicator of cardiovascular disease and an independent marker of morbidity and cardiovascular mortality. We investigated the association of arterial wave reflections with left ventricular (LV) diastolic dysfunction and their incremental value to other determinants of LV diastolic dysfunction in patients with essential hypertension. In total 143 patients and 20 controls with similar atherosclerotic risk factors were examined by applanation tonometry of the radial artery (Sphygmocor) and echocardiography. Central augmentation index (CAI%) of reflected arterial waves as well as aortic strain (AoS) assessed by echocardiography were estimated. Doppler diastolic abnormalities were defined as proposed by the European Study Group on diastolic heart failure by measurement of E/A ratio (the ratio of the mitral inflow velocities), isovolumic relaxation time, deceleration time and flow propagation velocity. AoS and CAI were impaired in patients compared with controls (4.67 ± 2.94 vs 6.06 ± 4.91% and 145.8 ± 22.7 vs 135.7 ± 20.3%, Po0.01) as well as in patients with LV diastolic dysfunction compared to patients without, (5.52 ± 4.29 vs 10.73 ± 5.77% and 139.5 ± 21.7 vs 124.5 ± 17.0%, Po0.05). The odds ratio (OR) of AoS and CAI for diastolic dysfunction was OR:0.918, 95% confidence interval (CI):0.837-0.99, P ¼ 0.04 and OR:1.023, 95%CI: 1.023-1.040 P ¼ 0.010, respectively. The addition of CAI to the multivariable model including age, LV mass index, AoS and mean arterial pressure increased the power of the model for determination of LV diastolic dysfunction (À2 log likelihood ¼ 139.368, change of v 2 ¼ 4.2, P-value for change ¼ 0.04). In untreated patients with newly diagnosed essential hypertension, wave reflections are independent and additive determinants of LV diastolic dysfunction.

show abstract

Aorta wall motion monitoring by 1-d MRI of perpendicular diameters

Chia

Wood

Leung

et al. 1999

J. Magn. Reson. Imaging

View full text Add to dashboard Cite

Aortic stiffness in young patients with heterozygous familial hypercholesterolemia

Cited by 126 publications

References 21 publications

<b>Color Doppler Tissue Imaging in Assessing the Elastic Properties of the Aorta and in Predicting Coronary Artery Disease</b>

<b>Color Doppler Tissue Imaging in Assessing the Elastic Properties of the Aorta and in Predicting Coronary Artery Disease</b>

Incremental value of arterial wave reflections in the determination of left ventricular diastolic dysfunction in untreated patients with essential hypertension

Aorta wall motion monitoring by 1-d MRI of perpendicular diameters

Contact Info

Product

Resources

About