Aortic Stiffness May Be Affected by Body Mass Index

Güleç, Mustafa

doi:10.1159/000480084

Cited by 1 publication

(1 citation statement)

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“…Atherosclerosis has also been reported to be the major mechanism involved in CAD [3]. Studies have shown that obesity is an important parameter as a risk factor for coronary arteriosclerosis and consequently for the increased risk of myocardial infarction [4-6]. Different types of proinflammatory or anti-inflammatory mediators, as well as cytokines, are secreted from adipose tissue called adipokines (or adipocytokines) [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients

et al. 2020

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Objective: Adipolin/C1q/TNF-related protein-12 is a family of CTRPs highly expressed in adipose tissue with glucose-lowering and anti-inflammatory effects. Various risk factors have been suggested in the incidence of cardiovascular diseases, such as a decrease in anti-inflammatory or an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of adipolin with anthropometric, angiographic, echocardiographic, and biochemical parameters. Subject and Methods: A total of 90 patients who were candidates for angiography were included in the study and divided into 3 groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as a control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects. Results: Serum adipolin levels were significantly decreased in patients with AMI compared with the SAP and control groups (p < 0.001 for both). In addition, there was a negative association between serum levels of adipolin and epicardial fat thickness (EFT) and Gensini score in CAD patients. The results of multivariate linear regression analysis revealed that EFT values were independently associated with serum adipolin levels. Conclusion: The current study showed an independent association of adipolin with EFT for the first time in patients with AMI. Decreased adipolin levels in patients with AMI may be involved in the process of atherosclerosis, which requires further study.

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