Aortic thrombosis in the neonate

Successful thrombolysis of a symptomatic neonatal aortic thrombosis associated with hypernatraemic dehydration - case report and literature review

“…The term ‘spontaneous aortic thrombosis’ is applied to neonatal cases of aortic thrombosis in which the umbilical artery has not been catheterised (13). It is very rare and is lethal in almost all reported cases (13–17).…”

Aortic Arch Thrombosis in a Neonate With Heterozygous Carrier Status of Factor V Leiden Mutation

“…Medline search of English literature over the last 20 years detected only 12 cases, similar to the one we have described (see the table). [7][8][9][10][11][12][13][14][15][16][17] This clinical entity usually manifests within the first hours to days of life with severe heart failure and symptoms mimicking coarctation or interruption of the aorta. Other more frequently suggested diagnoses include cyanotic congenital heart disease and hypoplastic left heart.…”

“…11,16 Both surgery and thrombolysis have been advocated as possible primary treatment options. 9,[13][14][15]28 Surgery offers the advantage of immediate relief of the life-threatening obstruction and has been successfully used in the treatment of organized, partially calcified thrombi in the aortic arch, without the involvement of other major vessels. [13][14][15] Rethrombosis may occur, necessitating postoperative anticoagulation.…”

“…[13][14][15] Rethrombosis may occur, necessitating postoperative anticoagulation. 9 The feasibility of surgical treatment in thrombosis, starting proximal to the origin of the innominate artery, has been questioned. 16 Some authors have advocated a primary trial of thrombolytic therapy in a clinically stable child; successful resolution of abdominal aortal as well as aortic arch thrombi has been achieved by thrombolysis alone.…”

Peripheral arterial occlusion in infants—A report of two cases treated conservatively

“…>3 Since 1935 several cases of primary occlusion of arterial vessels have been reported in the literature without clear etiological explanations of the events. [4][5][6][7] We would like to describe two new cases of newborns with this type of problem: one with right femoral artery obstruction and one with left c o m m o n iliac artery obstruction. These conditions were diagnosed in the first days of life, and both infants were referred to our hospital from the same geographical area within a 2-week period.…”