Aortic thrombus and multiple embolisms during a Mycoplasma pneumoniae infection

Flateau, C.; Asfalou, Iliyasse; Deman, A.-L.; Ficko, C.; Andriamanantena, D.; Fontán, E.; Viant, E.; Bonnevie, L.; Rapp, C.

doi:10.1007/s15010-013-0475-2

Cited by 27 publications

(30 citation statements)

References 29 publications

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“…There is a report of several cases of transient protein C and S deficiencies following varicella infection [32]. Also, Mycoplasma pneumoniae infection can induce a hypercoagulable state through transient antiphospholipid antibody syndrome [33–35]. Finally, DVT has also been reported in association with Dengue fever [36], which has already been reported to be associated with GBS and neuro-ophthalmic involvement [37].…”

Section: Discussionmentioning

confidence: 99%

A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?

2017

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Patient: Male, 32Final Diagnosis: Miller Fisher syndromeSymptoms: Ataxia • headache • ophthalmoplegiaMedication: —Clinical Procedure: PlasmapheresisSpecialty: NeurologyObjective:Rare co-existance of disease or pathologyBackground:Miller Fisher Syndrome is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia, and is considered to be a variant of Guillain-Barre Syndrome. Miller Fisher Syndrome is observed in approximately 1–5% of all Guillain-Barre cases in Western countries. Patients with Miller Fisher Syndrome usually have good recovery without residual deficits. Venous thromboembolism is a common complication of Guillain-Barre Syndrome and has also been reported in Miller Fisher Syndrome, but it has generally been reported in the presence of at least one prothrombotic risk factor such as immobility. A direct correlation between venous thromboembolism and Miller Fisher Syndrome or Guillain-Barre Syndrome has not been previously described.Case Report:We report the case of a 32-year-old Hispanic male who presented with acute, severe thromboembolic disease and concurrently demonstrated characteristic clinical features of Miller Fisher Syndrome including ophthalmoplegia, ataxia, and areflexia. Past medical and family history were negative for thromboembolic disease, and subsequent hypercoagulability workup was unremarkable. During the course of hospitalization, the patient also developed angioedema.Conclusions:We describe a possible association between Miller Fisher Syndrome, thromboembolic disease, and angioedema.

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Section: Discussionmentioning

confidence: 99%

A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?

2017

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“…Since the differentiation between SI due to various metastatic cancers is limited, patients with solid organ malignancy were excluded from this study. We investigated the patients' medical records for risk factors of SI such as trauma, vasculitis, pancreatitis, pancreatic tumor, surgical technique, invasive procedures, hematologic malignancy, liver cirrhosis with portal hypertension, atrial brillation, atherosclerotic disease, and hypercoagulative status (5). SI-associated radiologic ndings were analyzed in the context of splenomegaly with signs of obstruction/infarction in other organs.…”

Section: Overall Design and Study Populationmentioning

confidence: 99%

“…In clinical practice, SI is often detected incidentally when abdominal computed tomography (CT) scan is performed to identify the cause of fever. While several studies have shown that various pathogens can cause SI [4][5][6][7][8], comprehensive studies on the association between SI and infection are limited. One retrospective study showed that 4 of 32 patients with SI had infections [3], whereas another study identi ed infection as the causative factor in 11 of 89 patients with SI [9].…”

Section: Introductionmentioning

confidence: 99%

Splenic Infarction and Infectious Diseases in Korea

Chung²,

Lee

et al. 2020

Preprint

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Background Although the etiology of splenic infarction (SI) is multi-factorial, the nature of its relationship with infectious diseases is not well understood. We thus aimed to investigate the relationship between SI and infection using a retrospective approach. Methods We reviewed the hospital records of patients with SI who visited Inha University Hospital (Incheon, Republic of Korea) between January 2008 and December 2018. We collected and analyzed data on the patients’ clinical presentation, causative pathogens, risk factors, and radiologic findings. Results Of the 353 patients with SI, 101 patients with infectious conditions were enrolled in the study and their data were analyzed to identify an association between SI and infection. Ten patients were diagnosed as having infective endocarditis (IE), and 26 patients had bacteremia without IE. Twenty-seven patients had systemic infection due to miscellaneous causes (negative result on conventional automatic blood culture), such as the following intracellular organisms: parasites (12 cases of malaria and 1 case of babesiosis), bacteria (five cases of scrub typhus), viruses (one case each of Epstein–Barr virus infection and cytomegalovirus infection) or not identified pathogen (seven cases). Splenomegaly was more common among patients with miscellaneous systemic infection, and infarction involving other organs was rare. Twenty-one patients had localized infections (e.g. respiratory, intra-abdominal, or skin and soft tissue infection), and most of them (18 of 21) had other risk factors of SI. Conclusions In this study, various infectious conditions were found to be associated with SI, and intracellular organisms were the most common pathogens observed. Further studies are needed to examine other possible etiologies and the underlying pathophysiologic mechanisms.

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“…A recent review reported a total of 23 cases of arterial and venous thromboses involving several localisations (lower limbs, cerebral, mesenteric, spleen, pulmonary and intracardiac) during M pneumoniae infection 3. Most patients were children and had no congenital factors predisposing to thromboses.…”

Section: Fmdbmentioning

confidence: 99%

An adolescent with persistent cough, abdominal pain and refusal to walk from Salesi Children's Hospital

Angeloni

Carloni

Osimani

et al. 2014

Thorax

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A 12-year-old boy was admitted to our unit for a 3-day history of abdominal and right groin pain, refusal to walk and relapse of fever. His clinical history was uneventful until 2 weeks before, when he developed acute onset of fever, cough and breathlessness. Right upper lobe pneumonia was diagnosed by chest X-ray and intramuscular ceftriaxone treatment was administered for 10 days followed by fever reduction after 3-day therapy. On admission, he appeared quite unwell with fever and wet cough. He was moderately tachycardic and tachypnoeic with oxygen saturations of 94% in air. Chest examination revealed dullness to percussion and reduced breath sound over the upper right lung field with a few crackles. Abdomen was diffusely painful and tender to palpation in the left upper quadrant. Mild splenomegaly was also evident. The proximal portion of the right thigh appeared moderately swollen and warm, with no skin colour changes. Laboratory investigation revealed 23 000/mm 3 white blood cells (77% neutrophils), with normal platelet count and haemoglobin level. Erythrocyte sedimentation rate and C reactive protein were 48 mm/h and 7.4 mg/dL (<0.5), respectively. Liver and renal function tests were normal. Repeated chest X-rays revealed right upper lobe consolidation. FMDB (SENIOR CLINICIAN)We have a previously healthy young boy with persistence of clinical and radiological findings of pneumonia who developed non-respiratory symptoms over the last few days. Correct drug administration, antibiotic resistance, aggravating or underlying conditions, complicated pneumonia and aetiological agents unresponsive to treatment should be taken into account in similar cases. Streptococcus pneumoniae is the most common bacterial cause of community-acquired pneumonia in childhood. Although amoxicillin is recommended as first choice drug for antibiotic therapy, administration of cephalosporins may represent an alternative.1 The patient received correct ceftriaxone dosage, the duration of treatment was adequate, and pneumococcal β-lactam non-susceptibility is rare in Italy. The personal history was not suggestive of either aggravating conditions such as immunodeficiency or underlying lung disease such as cystic fibrosis or immotile cilia dyskinesia. Empyema, necrotising pneumonia and lung abscess represent possible complications of pneumonia, but they can be reasonably excluded by chest X-ray. The role of other aetiological agents such as Mycoplasma pneumoniae and virus should be considered and proper investigation be performed. PO (INFECTIVOLOGIST)Blood cultures were negative. Real-time PCR analysis on blood sample for S pneumoniae and on nasopharyngeal samples for 10 respiratory viruses was also negative. M pneumoniae serology revealed negative immunoglobulin M (IgM) and positive IgG value that was suggestive of past infection. Cold agglutinins were positive (1 : 512) across the thermal range of 4°C -20°C and negative at 37°C. FMDBThese laboratory data do not exclude a recent M pneumoniae infection. Indeed, high titres of cold (IgM)-ag...

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Aortic thrombus and multiple embolisms during a Mycoplasma pneumoniae infection

Cited by 27 publications

References 29 publications

A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?

A Case of Miller Fisher Syndrome, Thromboembolic Disease, and Angioedema: Association or Coincidence?

Splenic Infarction and Infectious Diseases in Korea

An adolescent with persistent cough, abdominal pain and refusal to walk from Salesi Children's Hospital

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