Aortic valve insufficiency and myocardial melanoma in a horse

Kovac, M; Ueberschär, S; Nowak, Martina; Prange, Timo; Mundt-Wüstenberg, S

doi:10.21836/pem20050502

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…EMM usually starts with small solitary dermal tumours at various cutaneous (ventral tail, perianal region, eyelid, lip) or visceral (guttural pouch, parotid) predilection sites ( Figure 1). Visceral metastases can occur not only in parenchymal organs (Figure 2), bone-marrow and mesentery, but also in skeletal muscle (Rodriguez et al 1998, Patterson-Kane et al 2001, Macgillivray et al 2002, Kovac 2005, Garvican et al 2007. Masses may compress the peripheral nerves (Murray et al 1997) or the spinal cord and, therefore, lead to neurologic deficits (Patterson-Kane et al 2001, Rosengren Pielberg et al 2008.…”

Section: Clinical Signs In Diseased Horsesmentioning

confidence: 99%

Aetiology, clinical presentation and current treatment options of equine malignant melanoma – a review of the literature

Cavalleri¹,

Mählmann²,

Steinig³

et al. 2014

PHK

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Summary: This review aims at giving an overview of the aetiology, genetic basis and clinical signs of equine malignant melanoma (EMM), the diagnostic work-up and the current treatment options. The established association between certain genetic features and melanoma formation in horses is reviewed. Typically, grey horses are affected with EMM. Typical predilection sites are the ventral tail, perianal region, eyelids, lips, parotid, or guttural pouches. Tumours usually grow slowly, but frequently metastasize eventually. Chemotherapy with cisplatin, 5-Fluorouracil and cimetidine are reviewed. Surgical excision of solitary small tumours can be successful, but has no systemic therapeutic effect and cannot prevent tumour recurrence. In conclusion, therapeutic options are still limited and conventional therapy is hardly curative. Current research focuses on immune modifying therapies using either tumour antigens for therapeutic vaccination or antitumoural interleukins. The most promising therapeutic approach currently under investigation is gene therapy using a xenogenic DNA vaccine coding for tumour associated antigens such as tyrosinase and gene therapy using interleukin-12 and -18.

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Section: Clinical Signs In Diseased Horsesmentioning

confidence: 99%

Aetiology, clinical presentation and current treatment options of equine malignant melanoma – a review of the literature

Cavalleri¹,

Mählmann²,

Steinig³

et al. 2014

PHK

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“…Entsprechend der entzündlichen Form werden bei degenerativen Klappenveränderungen ebenfalls rheologische und mechanische Einflüsse diskutiert, die durch Zugwirkung auf das Klappenstroma das Wachstumsverhalten der Fibroblasten beeinflussen. So kann durch den veränder-ten Kollagen-und Proteoglykanstoffwechsel neues Bindegewebe gebildet werden und knotige oder plaqueartige Klappenverdickungen entstehen (Kovac et al 2005).…”

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Acute heart insufficiency due to aortic rupture

Sundermann¹

2009

PHK

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EinleitungDie häufigste Herzerkrankung beim Pferd ist die Insuffizienz einer oder mehrerer Herzklappen. Sie wird in der Regel im Rahmen der klinischen Untersuchung sowohl bei leistungsschwachen als auch klinisch unauffälligen Pferden durch auftretende Nebengeräusche festgestellt. Die vorwiegend betroffene Klappe beim Pferd ist nach der Mitralklappe die Aortenklappe (Aortenklappeninsuffizienz, AVI) (Marr 1999). Dabei wird zwischen der akuten und chronischen Klappeninsuffizienz unterschieden.Die akute AVI wird meist durch charakteristische vegetative Veränderungen aufgrund einer bakteriellen, vorwiegend subakut verlaufenden Endokarditis ausgelöst (Stadler et al. 1995, Fröhlich et al. 2004. Dagegen liegen bei der chronischen AVI eher degenerative Schäden an den Noduli und bandoder knotenartige fibröse Verdickungen vor (Else und Holmes 1972, Marr 1999 Schlüsselwörter: Pferd-Echokardiografie-Herzinsuffizienz-Aorteninsuffizienz-Klappenruptur Acute heart insufficiency due to aortic rupture This report documents the case of an acute heart insufficiency due to rupture of an aortic valve in an 18 year old warmblood gelding. The horse was referred with the history of sudden poor performance, disturbed condition and a cardiac murmur. During clinical and echocardiographical examination an acute heart insufficiency with involvement of the lung and low to high grade insufficiency of all four heart valves were diagnosed. As induction of acute heart insufficiency, a rupture of left coronary aortic valve was detected. The horse was euthanized on account of the progression and infaust prognosis. The pathomorphology and -histology examination showed a chronic endocarditis as cause of the valve rupture. The etiology and pathogenesis of the acute aortic regurgitation and the acute heart insufficiency will be exemplified and discussed.Keywords: horse-echocardiography-heart insufficiency-aortic insufficiency-valve rupture T. Sundermann Pferdeheilkunde 25

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Pericardial Disease, Myocardial Disease, and Great Vessel Abnormalities in Horses

Decloedt

2019

Veterinary Clinics of North America: Equine Practice

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Aortic valve insufficiency and myocardial melanoma in a horse

Cited by 3 publications

References 12 publications

Aetiology, clinical presentation and current treatment options of equine malignant melanoma – a review of the literature

Aetiology, clinical presentation and current treatment options of equine malignant melanoma – a review of the literature

Acute heart insufficiency due to aortic rupture

Pericardial Disease, Myocardial Disease, and Great Vessel Abnormalities in Horses

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