Apathy and fatigue in autistic spectrum disorder improved by Japanese herbal medicine: TSUMURA Ninjin'yoeito extract

Sato, Shinji

doi:10.1111/pcn.12667

Cited by 9 publications

(9 citation statements)

References 3 publications

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“…Table 4 presents the list of clinical studies and Table 5 presents the list of case reports of NYT according to the search strategy. Five randomized clinical trials (RCT) [59][60][61][62][63], four observational studies [64][65][66][67], and 12 case reports were searched [68][69][70][71][72][73][74][75][76][77][78][79][80]. Herein, we summarize the findings of clinical studies on NYT.…”

Section: Clinical Results and Applications From Clinical Trials And C...mentioning

confidence: 99%

“…Patients with apathy and fatigue in autistic spectrum disorder (4) Fatigue and apathy improved. 2018 [78] Abbreviation: COPD, chronic obstructive pulmonary disease; Hb, hemoglobin; NYT, ninjin'yoeito; SF-36, Study 36-Item Short-Form Health Survey.…”

Section: [72]mentioning

confidence: 99%

“…Sato et al reported four cases of apathy and fatigue in patients with autistic spectrum disorder whose fatigue and apathy were improved by NYT [78].…”

Section: Fatigue/malaise and Anorexiamentioning

confidence: 99%

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Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Takayama,

Michihara,

Kimura

et al. 2023

Traditional & Kampo Medicine

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BackgroundThe source of ninjin'yoeito (NYT) is considered the ‘Formulary of Bureau of Taiping People's Welfare Pharmacy’, written around 1241–52 AD. NYT is used to treat patients with chronic fatigue, malaise with qi deficiency, and exhaustion of all five parenchymatous viscera with difficulty in recovering.Key FindingsNYT formula consists of 12 crude drugs. NYT extract for medical use is covered by the National Health Insurance system of Japan for convalescence after recovery from diseases, fatigue and malaise, anorexia, perspiration during sleep, cold limbs, and anemia. Studies have shown clinical effects of NYT: treatment of anemia, cancer treatment support, frailty, cognitive dysfunction, apathy, fatigue/malaise, anorexia, and lung diseases. Preclinical studies support clinical studies; activating ghrelin‐neuropeptide Y pathway‐mediated appetite‐enhancing effects, inhibiting muscle volume loss through the Akt/mTOR pathway‐mediated hyperphosphorylation of 4E‐BP1 and FoxO1‐mediated Atrogin‐1, suppressing the hypothalamic–pituitary–adrenal axis by downregulating the sympathetic‐adrenal‐medullary axis and GABA neurons for improving sociability, promoting recovery from skeletal muscle atrophy through the activation of PGC‐1α, hematopoiesis‐promoting effects, and increasing the number of immune cells in immunocompromised models. The incidence of adverse events of NYT was reported as 3.09 or 2.03%. The most significant adverse effects of NYT are gastrointestinal disorders.ConclusionRecently, NYT has been widely used to treat several symptoms and conditions under the National Health Insurance System of Japan. Clinical studies showed the efficacy of NYT to treat anemia, frailty, cognitive dysfunction, anorexia, apathy, and fatigue/malaise, as well as for long‐term cancer treatment support. The pharmacological mechanisms supporting its effects are also being reported.

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Section: Clinical Results and Applications From Clinical Trials And C...mentioning

confidence: 99%

Section: [72]mentioning

confidence: 99%

See 1 more Smart Citation

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Takayama,

Michihara,

Kimura

et al. 2023

Traditional & Kampo Medicine

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show abstract

“…Another possibility is that there is as association between inflammation and apathy symptoms [13]. NYT is reported to improve inflammation in particular [14], and thus might reduce apathy in MCI patients [15]. Confirmation of the effectiveness of NYT for the improvement of apathy in MCI a controlled study of a large number of MCI will be necessary to confirm these findings.…”

Section: Discussionmentioning

confidence: 97%

Ninjin'yoeito (Tsumura) Extract; a Kampo (traditional herbal medicine) Improved Apathy in a Mild Cognitive Impairment Patient

Sato

Tamura²,

Takahashi

et al. 2018

CNPT

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Apathy, characterized by lack of motivation and loss of initiative, is a common symptom with all forms of dementia. The traditional Japanese medicine: Ninjin'yoeito (NYT) has been reported to improve anemia, fatigue, loss of appetite, and anorexia in patients with Alzheimer's disease. We reported here the case of a 71year-old female with mild cognitive impairment (MCI) and apathy. NYT improved her apathy symptoms effectively, without any adverse effects, including cognitive decline. Our findings suggest that apathy symptoms in MCI patients can be improved without prescribing cholinesterase inhibitors.

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“…As it translates to "ginseng nutritive decoction," based on its main ingredient, it is known to improve the nutritional status and used as herbal medicine for symptomatic treatment of "post-illness weakness, fatigue, loss of appetite, night sweats, cold extremities, and anemia." Previous clinical and preclinical studies concluded on its effectiveness in anemia [17,18], fatigue [19][20][21][22][23][24][25], and psychological conditions, namely anxiety and depression, as well as lethargy and apathy associated with Alzheimer's and Parkinson's diseases [26][27][28][29][30]. However, very little prospective research has been performed to investigate the effects of administering NYT in patients having preoperative anemia with unspeci ed symptoms, especially for gynecological diseases.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Ninjin’yoeito for Preoperative Anemia, Fatigue, and Anxiety in Patients with Gynecological Disease: an Open-Label, Single-Center, Randomized Phase-II Trial.

Yagi

Sawada

Miyamoto

et al. 2021

Preprint

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Background: Preoperative anemia affects perioperative outcomes and often causes fatigue and psychological disorders. Therefore, anemia should be treated before a patient undergoes surgery. Ninjin’yoeito (NYT), a Japanese Kampo medicine composed of ginseng and Japanese angelica root with the other 10 herbs, is administered for anemia, fatigue and anxiety; however, there are a few reports that have prospectively examined the effects of NYT before surgery for gynecological diseases. Hence, we tended to investigate its efficacy and safety.Methods: In this open-label randomized trial, women with gynecological diseases accompanied by preoperative anemia (defined as <11.0 g/dL Hemoglobin [Hb]) were randomly assigned (1:1) into the iron supplementation and NYT groups. Patients of the iron supplementation group and the NYT group received 100 mg/day iron supplementation with and without NYT (7.5 g/day) for at least 10 days before surgery. The primary endpoint was improvement in Hb levels before and after treatment, and Cancer Fatigue Scale (CFS) and Visual Analogue Scale for Anxiety (VAS-A) scores between groups. Statistical analyses were performed with Wilcoxon signed rank test, Wilcoxon rank sum test, and Fisher’s exact test as appropriate.Results: 40 patients were enrolled of whom 30 patients were finally analyzed after allocating 15 to each group. There was no difference in the characteristics between both groups. Hb significantly increased in both groups (iron supplementation group, 9.9 ± 0.8 g/dL vs. 11.9 ± 1.6 g/dL; NYT group, 9.8 ± 1.0 g/dL vs. 12.0 ± 1.0 g/dL); the difference in the elevations in Hb between both groups was statistically insignificant (P = 0.72). Contrarily, CFS (17.9 ± 10.2 vs. 8.1 ± 5.2) and VAS-A (56 mm (50–70) vs. 23 mm (6–48)) scores were significantly decreased only in the NYT group and these changes were greater in the NYT group (∆CFS, P = 0.015; ∆VAS-A, P = 0.014). Liver dysfunction occurred in one patient of the NYT group.Conclusions: For treating preoperative anemia in women with gynecological conditions, NYT administration along with iron supplementation safely and efficiently improved the preoperative anemia, fatigue and anxiety.Trial registration: jRCT1051190012 (28/April/2019, retrospectively registered).

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Apathy and fatigue in autistic spectrum disorder improved by Japanese herbal medicine: TSUMURA Ninjin'yoeito extract

Cited by 9 publications

References 3 publications

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Ninjin'yoeito (Tsumura) Extract; a Kampo (traditional herbal medicine) Improved Apathy in a Mild Cognitive Impairment Patient

Efficacy of Ninjin’yoeito for Preoperative Anemia, Fatigue, and Anxiety in Patients with Gynecological Disease: an Open-Label, Single-Center, Randomized Phase-II Trial.

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