2021
DOI: 10.1016/j.intimp.2021.108230
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Apelin-13-Mediated AMPK ameliorates endothelial barrier dysfunction in acute lung injury mice via improvement of mitochondrial function and autophagy

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Cited by 22 publications
(9 citation statements)
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“…A study by Kong et al showed that apelin-13 enhanced AMPK phosphorylation to regulate mitochondrial function to improve the pulmonary endothelial barrier in ALI mice. 30 Zhang et al reported that apelin-13 reduced IL-1β release, suppressed activation of NLRP3 inflammasome, and inhibited the NF-κB pathway in RAW264.7 cells. 31 Nevertheless, the effect of apelin-13 on LPS-induced inflammation in primary macrophages remains unclear, and whether apelin-13 can be used to improve macrophage oxidative stress and thus glycolysis are still mostly unknown.…”
Section: Introductionmentioning
confidence: 99%
“…A study by Kong et al showed that apelin-13 enhanced AMPK phosphorylation to regulate mitochondrial function to improve the pulmonary endothelial barrier in ALI mice. 30 Zhang et al reported that apelin-13 reduced IL-1β release, suppressed activation of NLRP3 inflammasome, and inhibited the NF-κB pathway in RAW264.7 cells. 31 Nevertheless, the effect of apelin-13 on LPS-induced inflammation in primary macrophages remains unclear, and whether apelin-13 can be used to improve macrophage oxidative stress and thus glycolysis are still mostly unknown.…”
Section: Introductionmentioning
confidence: 99%
“…On the one hand, enhanced mitochondrial function can reduce the activation of mechanically sensitive calcium channels, reduce the influx of calcium ions, and thus reduce the permeability of endothelial cells (10). On the other hand, reactive oxygen species (ROS) produced by mitochondrial dysfunction are also important factors that damage connexins (11). Therefore, supporting mitochondrial maintenance may be key in preventing VILI.…”
mentioning
confidence: 99%
“…Apelin-13 is the main neuroprotective peptide, with the highest abundancy in the plasma ( 13 , 14 ). Previous research reported that apelin-13 participates in vasculopathy, energy metabolism, and humoral homeostasis ( 13 , 15 , 16 ). There was also a study that discovered the downregulation of apelin-13 in aging.…”
Section: Apelin–apj Receptor System Discovery and Developmentmentioning
confidence: 99%