Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia

Nováková, V.; Sandhu, Gurpreet S.; Dragomir-Daescu, Dan; Klabusay, Martin

doi:10.1016/j.vph.2015.08.005

Cited by 34 publications

(26 citation statements)

References 136 publications

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“…Accumulated evidence indicates that apelin/APLNR improves the recovery from ischemic stroke by inhibiting cell death and facilitating angiogenesis, which are mediated by the activation of PI3K/AKT and ERKs signaling pathways, respectively (Figure 3; Chuang et al, 2011; Tao et al, 2011; Gu et al, 2013; Wang et al, 2013; Zhu et al, 2013; Yang et al, 2014; Chen et al, 2015; Liu et al, 2015; Huang et al, 2016; Novakova et al, 2016; Zou et al, 2016). Oxidative stress is a major mechanism of ischemia/reperfusion injury, leading to cell death.…”

Section: Protective Effects Of Apelin/aplnr In Ischemic Stroke and Thmentioning

confidence: 99%

“…Apelin facilitates angiogenesis and blood flow restoration, which is dependent on an increase in vascular endothelial growth factor- vascular endothelial growth factor receptor 2 (VEGF-VEGFR2) signaling . In addition, PI3K/AKT and ERKs signaling pathways play a crucial role in apelin/APLNR-induced angiogenesis in ischemic stroke, which may be mediated by VEGF-VEGFR2 (Wang et al, 2013; Chen et al, 2015; Liu et al, 2015; Novakova et al, 2016). Consistently, loss of apelin impairs the angiogenesis and functional recovery (Wang et al, 2013).…”

Section: Protective Effects Of Apelin/aplnr In Ischemic Stroke and Thmentioning

confidence: 99%

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Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential

Wang

Zhou

et al. 2017

Front. Mol. Neurosci.

114

149

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Stroke is one of the leading causes of death and disability worldwide, and ischemic stroke accounts for approximately 87% of cases. Improving post-stroke recovery is a major challenge in stroke treatment. Accumulated evidence indicates that the apelinergic system, consisting of apelin and apelin receptor (APLNR), is temporally dysregulated in ischemic stroke. Moreover, the apelinergic system plays a pivotal role in post-stroke recovery by inhibiting neuronal apoptosis and facilitating angiogenesis through various molecular pathways. In this review article, we summarize the temporal expression of apelin and APLNR in ischemic stroke and the mechanisms of their dysregulation. In addition, the protective role of the apelinergic system in ischemic stroke and the underlying mechanisms of its protective effects are discussed. Furthermore, critical issues in activating the apelinergic system as a potential therapy will also be discussed. The aim of this review article is to shed light on exploiting the activation of the apelinergic system to treat ischemic stroke.

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Section: Protective Effects Of Apelin/aplnr In Ischemic Stroke and Thmentioning

confidence: 99%

Section: Protective Effects Of Apelin/aplnr In Ischemic Stroke and Thmentioning

confidence: 99%

Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential

Wang

Zhou

et al. 2017

Front. Mol. Neurosci.

114

149

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“…By contrast, lower apelin levels have a negative effect on vascular sprouting and angiogenesis 22 . Moreover, gene therapy that combines VEGF and apelin has been reported as a potential option for treating patients with MMD 35 . Therefore, the higher apelin levels in patients with MMD may explain their greater capacity for arteriogenesis and angiogenesis and their better clinical prognoses and outcomes compared with those for patients with ICAD 5 , as well as provide a better understanding of the pathology and aetiology of MMD.…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases

Jiang

et al. 2017

Sci Rep

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Patients with moyamoya disease (MMD) or intracranial atherosclerotic disease (ICAD) experience similar cerebral ischaemic events. However, MMD patients show greater angiogenesis and arteriogenesis, which play crucial roles in collateral circulation development to enhance clinical prognosis and outcome. Apelins have been associated with angiogenesis and arteriogenesis. Therefore, the aim of the present study was to determine whether apelin levels were higher in patients with MMD than in patients with ICAD or in healthy controls. We compared plasma apelin levels in 29 patients with MMD, 82 patients with ICAD, and 25 healthy participants. Twelve-hour fasting blood samples were collected and analysed using commercially available kits. Univariate analyses indicated that compared with the ICAD and healthy control groups, the MMD group had higher apelin-12, apelin-13, apelin-36, and nitric oxide levels. Binary logistic regression analyses further showed that the plasma apelin-12 level was substantially higher in MMD patients than in ICAD patients. Patients with MMD were also differentiated from patients with ICAD by their mean ages, with the former being younger. Therefore, the plasma apelin-12 level is a potential diagnostic marker for differentiating MMD and ICAD and may provide a treatment strategy for enhancing collateral circulation development and clinical prognosis and outcome.

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“…Apelin protects cardiomyocytes against oxidative stress in ischemia/reperfusion injury and reduces cellular apoptosis (Szokodi et al, ; Berry et al, ; Atluri et al, ; Zeng et al, ; Azizi et al, ). It is involved in different signal transduction pathways regulating angiogenesis in hypoxic conditions (Novakova et al, ). Apelin also exerts protective effects against CVDs associated with obesity and diabetes.…”

Section: Apelin and Stem Cells: Effects On Cardiovascular Systemmentioning

confidence: 99%

Apelin and stem cells: the role played in the cardiovascular system and energy metabolism

Esmaeili

Bandarian

Esmaeili

et al. 2019

Cell Biology International

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Apelin, a member of the adipokine family, is widely distributed in the body and exerts cytoprotective effects on many organs. Apelin isoforms are involved in different physiological processes, including regulation of the cardiovascular system, cardiac contractility, angiogenesis, and energy metabolism. Several investigations have been performed to study the effect of apelin on stem cell therapy. This review aims to summarize the literature representing the effects of apelin on stem cell properties. Furthermore, this review discusses the therapeutic potential of apelin-treated stem cells for cardiovascular diseases and demonstrates the effect of stem cells overexpressing apelin on energy metabolism. Stem cells with their unique characteristics play a crucial role in the maintenance of tissue integrity. These cells participate in tissue regeneration via multiple mechanisms. Although preclinical and clinical studies have demonstrated the therapeutic potential of stem cells in various diseases, their application in regenerative medicine has not been efficient. A number of strategies such as genetic modification or treatment of stem cells with different factors have been used to improve the efficacy of cell therapy and to increase their survival after transplantation. This article reviews the effect of apelin treatment on the efficacy of cell therapy.

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Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia

Cited by 34 publications

References 136 publications

Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential

Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential

Prospective evaluation of the diagnostic value of plasma apelin 12 levels for differentiating patients with moyamoya and intracranial atherosclerotic diseases

Apelin and stem cells: the role played in the cardiovascular system and energy metabolism

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