Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease

Jangdey, Manmohan Singh; Gupta, Anshita; Sarwa, Khomendra Kumar

doi:10.20510/ukjpb/6/i1/173531

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…It is common in parsley, grapes, red wine, chamomile tea, and apples. Typically, apigenin is conjugated to a glycoside (Jang et al, 2022 ; Jangdey et al, 2018 ).…”

Section: Overview Of Apigeninmentioning

confidence: 99%

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Daneshvar,

Zamanian,

Ivraghi

et al. 2023

Food Science & Nutrition

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Colon cancer (CC) is one of the most common and deadly cancers worldwide. Oncologists are facing challenges such as development of drug resistance and lack of suitable drug options for CC treatment. Flavonoids are a group of natural compounds found in fruits, vegetables, and other plant‐based foods. According to research, they have a potential role in the prevention and treatment of cancer. Apigenin is a flavonoid that is present in many fruits and vegetables. It has been used as a natural antioxidant for a long time and has been considered due to its anticancer effects and low toxicity. The results of this review study show that apigenin has potential anticancer effects on CC cells through various mechanisms. In this comprehensive review, we present the cellular targets and signaling pathways of apigenin indicated to date in in vivo and in vitro CC models. Among the most important modulated pathways, Wnt/β‐catenin, PI3K/AKT/mTOR, MAPK/ERK, JNK, STAT3, Bcl‐xL and Mcl‐1, PKM2, and NF‐kB have been described. Furthermore, apigenin suppresses the cell cycle in G2/M phase in CC cells. In CC cells, apigenin‐induced apoptosis is increased by inhibiting the formation of autophagy. According to the results of this study, apigenin appears to have the potential to be a promising agent for CC therapy, but more research is required in the field of pharmacology and pharmacokinetics to establish the apigenin effects and its dosage for clinical studies.

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“…It is common in parsley, grapes, red wine, chamomile tea, and apples. Typically, apigenin is conjugated to a glycoside (Jang et al, 2022 ; Jangdey et al, 2018 ).…”

Section: Overview Of Apigeninmentioning

confidence: 99%

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Daneshvar,

Zamanian,

Ivraghi

et al. 2023

Food Science & Nutrition

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“…API exerts neuroprotective effects through multiple mechanisms, contributing to its potential therapeutic benefits in neurodegenerative diseases. [22] Here are some fundamental MoA associated with API:…”

Section: Moa In Neuroprotectionmentioning

confidence: 99%

Apigenin: Exploring its neuroprotective potential in neurodegenerative disorders: Mechanisms and promising therapeutic applications

Bhratee,

Anand,

Singh

2023

Pharmaspire

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Neurodegenerative diseases pose significant challenges to global health-care systems, highlighting the urgent need for effective therapeutic strategies. Apigenin (API), a natural compound derived from various plant sources, has emerged as a potential treatment option due to its neuroprotective properties. This review article provides a comprehensive overview of API, focusing on its definition, natural sources, pharmacokinetics, and bioavailability, mechanisms of action, safety, and tolerability profile. API protects neurons in many ways, including its antioxidant activity, anti-inflammatory properties, ability to change cellular signaling pathways, ability to stop proteins from misfolding and sticking together, and ability to improve mitochondrial function. In vitro studies have demonstrated that API attenuates oxidative stress, inhibits the formation of protein aggregates, and suppresses neuroinflammation. Animal models, such as transgenic mice, rat models, and non-human primates, have provided valuable insights into the potential therapeutic benefits of API, including improved cognitive function, mitigation of motor impairments, and preservation of neuronal integrity. API’s safety and tolerability profile appears favorable based on preclinical and clinical studies, with minimal reported adverse effects. However, further investigation is required to determine optimal dosing regimens and assess potential drug interactions. In addition, while current treatment options for neurodegenerative diseases primarily focus on symptom management, API holds promise as a disease-modifying agent.

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Flavonoids and Alzheimer’s disease: reviewing the evidence for neuroprotective potential

Al Amin,

Dehbia,

Nafady

et al. 2024

Mol Cell Biochem

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Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease

Cited by 4 publications

References 17 publications

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

A comprehensive view on the apigenin impact on colorectal cancer: Focusing on cellular and molecular mechanisms

Apigenin: Exploring its neuroprotective potential in neurodegenerative disorders: Mechanisms and promising therapeutic applications

Flavonoids and Alzheimer’s disease: reviewing the evidence for neuroprotective potential

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