Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice

Myoung, Hyeon-Jong; Kim, Gwang-Jung; Nam, Kwanghee

doi:10.1007/s12272-010-1105-5

Cited by 39 publications

(25 citation statements)

References 25 publications

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“…Olive leaf is a natural substance with therapeutic properties, and its extract contains several bioactive compounds including oleuropein, luteolin, hydroxytyrosol, apigenin, caffeic acid, and rutin (25). Recent studies demonstrated that olive leaf constituents improve management of obesity by decreasing the accumulation of intracellular lipid in the 3T3-L1 pre-adipocyte cell line (26)(27)(28)(29)(30)(31)(32). According to the results of these studies, OLE compound has anti-obesity effects.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice

Jung¹,

Kim²,

Min³

et al. 2019

In Vivo

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Background/Aim: The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models. Materials and Methods: C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue. Results: OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis-and thermogenesis-related molecules was decreased in the OLE-treated group. Conclusion: OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice

Jung¹,

Kim²,

Min³

et al. 2019

In Vivo

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“…Other polyphenols and polyphenol extracts modulate the neuropeptides involved in food intake and EE (reviewed in Panickar 32 ). For instance, resveratrol reduces Npy and Agrp expression, 33 and apigenin increases Pomc expression 34 in neuronal cell lines. These results reinforce the idea that specific polyphenols could improve central leptin signalling.…”

Section: Discussionmentioning

confidence: 99%

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity

et al. 2016

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Objective:Dietary obesity is usually linked with hypothalamic leptin resistance, in which the primary impact is an interference in the homeostatic control of body weight and appetite. Notably, proanthocyanidins (PACs), which are the most abundant phenolic compounds present in human diet, modulate adiposity and food intake. The aim of this study was to assess whether PACs could re-establish appropriate leptin signalling in both the hypothalamus and peripheral tissues.Design:Male Wistar rats were fed either a standard chow diet (STD group, n=7) or a cafeteria diet (CD) for 13 weeks. The CD-fed rats were treated with either grape-seed PAC extract (GSPE) at 25 mg per kg of body weight per day (CD+GSPE group, n=7) or with the vehicle (CD group, n=7) for the last 21 days of the study period. Specific markers for intracellular leptin signalling, inflammation and endoplasmic reticulum stress in the hypothalamus, liver, mesenteric white adipose tissue and skeletal muscle were analysed using immunoblotting and quantitative PCR.Results:GSPE treatment significantly reduced the food intake but did not reverse the hyperleptinemia and body wt gain assessed. However, the animals treated with GSPE exhibited greater hypothalamic activation of signal transducer and activator of transcription-3, which was associated with a rise in the Pomc mRNA levels compared with the CD group. In addition, this restoration of leptin responsiveness was accompanied by lower local inflammation and increased Sirt1 gene expression. The effects of the GSPE treatment in the peripheral tissues were not as evident as those in the hypothalamus, although the GSPE treatment significantly restored the mRNA levels of Socs3 and Ptp1b in the skeletal muscle.Conclusions:The use of GSPE reduces hyperphagia and improves the central and peripheral leptin resistance associated with diet-induced obesity. Our results suggest that GSPE could exert these effects partially by increasing Sirt1 expression and preventing hypothalamic inflammation.

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“…Oleuropein [23, 26], hydroxytyrosol [26, 27], luteolin [28], apigenin [29, 30], rutin [31], and caffeic acid [32] were found to decrease the accumulation of intracellular lipid, as detected by Oil Red O staining, and the expression of adipogenic transcription factors such as PPAR γ and C/EBP α in 3T3-L1 cells. Hydroxytyrosol also exerts beneficial effects on the promotion of mitochondrial biogenesis via stimulation of the PGC-1 α and its downstream target genes in 3T3-L1 cells [27].…”

Section: Discussionmentioning

confidence: 99%

“…Green et al demonstrated that oral gavage of dichloromethane extract of olive leaves improved glucose metabolism by significantly increasing plasma GLP-1 concentrations in mice [33]. Among the constituents of OLE, apigenin is known to inhibit food intake at the dosage of 0.05% by increasing the expression of POMC and CART in HFD-fed mice [29]. OLD used in the present study may contain much less apigenin than 0.05%, as, in an earlier report, leaf extract of Olea europaea L. contained 1.37% apigenin [37].…”

Section: Discussionmentioning

confidence: 99%

Olive Leaf Extract Attenuates Obesity in High‐Fat Diet‐Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis

Shen

Song

Keum

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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The present study aimed to investigate whether olive leaf extract (OLE) prevents high-fat diet (HFD)-induced obesity in mice and to explore the underlying mechanisms. Mice were randomly divided into groups that received a chow diet (CD), HFD, or 0.15% OLE-supplemented diet (OLD) for 8 weeks. OLD-fed mice showed significantly reduced body weight gain, visceral fat-pad weights, and plasma lipid levels as compared with HFD-fed mice. OLE significantly reversed the HFD-induced upregulation of WNT10b- and galanin-mediated signaling molecules and key adipogenic genes (PPARγ, C/EBPα, CD36, FAS, and leptin) in the epididymal adipose tissue of HFD-fed mice. Furthermore, the HFD-induced downregulation of thermogenic genes involved in uncoupled respiration (SIRT1, PGC1α, and UCP1) and mitochondrial biogenesis (TFAM, NRF-1, and COX2) was also significantly reversed by OLE. These results suggest that OLE exerts beneficial effects against obesity by regulating the expression of genes involved in adipogenesis and thermogenesis in the visceral adipose tissue of HFD-fed mice.

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Apigenin isolated from the seeds of Perilla frutescens britton var crispa (Benth.) inhibits food intake in C57BL/6J mice

Cited by 39 publications

References 25 publications

Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice

Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity

Olive Leaf Extract Attenuates Obesity in High‐Fat Diet‐Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis

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