Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263

Shao, Huanjie; Jiao, Kai; Mahmoud, Esraa; Huang, Haihong; Fang, Xianjun; Yu, Chunrong

doi:10.1158/1535-7163.mct-13-0066

Cited by 92 publications

(71 citation statements)

References 42 publications

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“…Moreover, apigenin significantly decreased the level of Her2/neu, a protein involved in growth factor signaling, which indicated a reduction in breast cancer cell proliferation in apigenin-treated mice 33. Apigenin also displayed significant antitumor activity in human colon cell implanted nude mice 34,35. The anti-metastatic activity of apigenin has also been reported in an orthotopic colorectal nude mouse model 36.…”

Section: Role Of Apigenin In Cancer Preventionmentioning

confidence: 84%

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

2016

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Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer chemopreventive agent has increased. Significant progress has been made in studying the chemopreventive aspects of apigenin both in vitro and in vivo. Several studies have demonstrated that the anticarcinogenic properties of apigenin occur through regulation of cellular response to oxidative stress and DNA damage, suppression of inflammation and angiogenesis, retardation of cell proliferation, and induction of autophagy and apoptosis. One of the most well-recognized mechanisms of apigenin is the capability to promote cell cycle arrest and induction of apoptosis through the p53-related pathway. A further role of apigenin in chemoprevention is the induction of autophagy in several human cancer cell lines. In this review, we discuss the details of apigenin, apoptosis, autophagy, and the role of apigenin in cancer chemoprevention via the induction of apoptosis and autophagy.

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Section: Role Of Apigenin In Cancer Preventionmentioning

confidence: 84%

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

2016

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“…Apigenin substantially upregulates CD26/DPPIV on human colorectal cancer HT-29 and HRT-18 cells to inhibit metastasis [81]. Synergistic interaction between apigenin and ABT-263, a BH3 mimetic inhibitor of the Bcl-2 family, was more potent than apigenin or ABT-263 alone in inhibiting tumor growth in xenograft tumors of colon cancer cells [82]. …”

Section: 0 Effect Of Apigenin In Various Human Cancersmentioning

confidence: 99%

Plant Flavone Apigenin: an Emerging Anticancer Agent

et al. 2017

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Research in cancer chemoprevention provides convincing evidence that increased intake of vegetables and fruits may reduce the risk of several human malignancies. Phytochemicals present therein provide beneficial anti-inflammatory and antioxidant properties that serve to improve the cellular microenvironment. Compounds known as flavonoids categorized anthocyanidins, flavonols, flavanones, flavonols, flavones, and isoflavones have shown considerable promise as chemopreventive agents. Apigenin (4′, 5, 7-trihydroxyflavone), a major plant flavone, possessing antioxidant, anti-inflammatory, and anticancer properties affecting several molecular and cellular targets used to treat various human diseases. Epidemiologic and case-control studies have suggested apigenin reduces the risk of certain cancers. Studies demonstrate that apigenin retain potent therapeutic properties alone and/or increases the efficacy of several chemotherapeutic drugs in combination on a variety of human cancers. Apigenin’s anticancer effects could also be due to its differential effects in causing minimal toxicity to normal cells with delayed plasma clearance and slow decomposition in liver increasing the systemic bioavailability in pharmacokinetic studies. Here we discuss the anticancer role of apigenin highlighting its potential activity as a chemopreventive and therapeutic agent. We also highlight the current caveats that preclude apigenin for its use in the human trials.

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“…Apigenin (4′,5,7‐trihydroxyflavone) belongs to the flavonoids family and commonly present in herbs, fruits, and vegetables (Perrott, Wiley, Desprez, & Campisi, ). Some studies with in vitro and in vivo models have already shown chemopreventive and chemotherapeutic effects of apigenin (Shao et al, ; Tong & Pelling, ). Anticarcinogenic effects of apigenin are exerted by the regulation of multiple cellular processes such as response to oxidative stress and DNA damage, activation of programmed cell death pathways such as autophagy and apoptosis, inhibition of inflammation, angiogenesis, and cell proliferation, in several human cancer cells (Sung, Chung, & Kim, ).…”

Section: Some Common Phytochemicals With Chemopreventive and Chemothementioning

confidence: 99%

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

Singh

Arora

Ansari

et al. 2019

Phytotherapy Research

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Naturally occurring phytochemicals or plant derivatives are now being explored extensively for their health's benefits and medicinal uses. The therapeutic effect of phytochemicals has been reported in several pathophysiological settings such as inflammatory disorders, metabolic disorders, liver dysfunction, neurodegenerative disorders, and nephropathies. However, the most warranted therapeutic effects of phytochemicals were mapped to their anticancerous and chemopreventive action. Moreover, combining phytochemicals with standard chemotherapy has shown promising results in cancer therapy with minimal side effects and better efficacy. Many phytochemicals, like curcumin, resveratrol, and epigallocatechin‐3‐gallate, have been extensively investigated for their chemopreventive as well as chemotherapeutic effects. However, poor bioavailability, low solubility, hydrophobicity, and obscure target specificity restrict their therapeutic applications in the clinic. There has been a continually increasing interest to formulate nanoformulations of phytochemicals by using various nanocarriers, such as liposomes, micelles, nanoemulsions, and nanoparticles, to improve their bioavailability and target specificity, thereby maximizing the therapeutic potential. In the present review, we have summarized chemopreventive as well as chemotherapeutic action of some common phytochemicals and their major limitations in clinical application. Also, we have given an overview of strategies that can improve the efficacy of phytochemicals for their chemotherapeutic value in clinical settings.

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Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263

Cited by 92 publications

References 42 publications

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy

Plant Flavone Apigenin: an Emerging Anticancer Agent

Phytochemicals based chemopreventive and chemotherapeutic strategies and modern technologies to overcome limitations for better clinical applications

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