Aplastic Anemia Terminating in Leukemia

Adult Leukemia Developing after Aplastic Anemia: Report of 8 Cases

“…On the basis of morphological and cytochemical findings 2 pa tients were classified as ALL, and 5 cases as ANLL. In 1 patient AA preceded a picture consistent with Ph'-negative chronic granulocytic leukemia; this se quence has been described in another case [20], Two patients (1 M 1 and 1 M5 ANLL with previous exposure to 60Co) showed a cytogenetic anomaly, del(5q), frequently documented in MDS, in ANLL from MDS, in therapy-related ANLL and in ANLL secondary to myelotoxic exposure [21], Since cytoge netic data were not taken during the aplastic phase, we are not able to say whether this chromosomal anomaly preceded overt leukemia or whether its ap pearance should be connected to the rising neoplastic clone.…”

The Aplasia-Leukaemia Syndrome

“…He subsequently developed a myeloproliferative syn drome, which transformed into acute myeloid leukaemia. He died 16 years after his in itial presentation.The occurrence of leukaemia as a com plication of aplastic anaemia has been re ported on several occasions [Degowin, 1963;Hellriegel et al, 1979;Milner and Geary, 1979]. This complication of aplas tic anaemia is uncommon and the patho genesis is unknown.…”