The goal of the present study is the development of a spectral method to obtain the frequency response of the half-vehicle subjected to a measured pavement roughness in the frequency domain. For this purpose, a half-vehicle dynamic model with a two-point delayed base excitation was developed to correlate with the spectral density function of the pavement roughness, to obtain the system spectral transfer function, in the frequency domain. The vertical pavement profile was measured along two roads sections. The surface roughness was here expressed in terms of the spectral density function of the measured vertical pavement profile with respect to the evenness wave number of the pavement roughness. A frequency response analysis was applied to obtain the vertical and angular modal vehicle dynamic response with the excitation of the power spectral density (PSD) of the pavement roughness. The results show that at low speed, the vehicle suspension mode is magnified due to the unpaved track signature. At 120 km/h in an undulated asphalted road, the first vehicle vibration mode has a significant motion amplification, which may cause passenger discomfort.