Aplysin induces apoptosis in glioma cells through HSP90/AKT pathway

Gong, Anjing; Gong, Lili; Yao, Weicheng; Ge, Na; Lu, Luxiang; Liang, Hui

doi:10.1177/1535370214555664

Cited by 17 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies reported that PI3K/Akt signalling pathway was associated with cadmium‐induced apoptosis in glial cells and proximal tubular cells . Our RNA‐Seq data showed HSP90 genes (HSP90B1 and HSP90AB1) were highly expressed in CdCl 2 ‐treated H9‐CMs, which may enhance phosphorylation of Akt to induce cell apoptosis (Figures ) . Above clues encouraged us to investigate whether PI3K‐Akt signalling pathway plays an important role in CIC.…”

Section: Resultssupporting

confidence: 51%

Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes

Shen

Wang

Zhou

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

Cadmium, a highly ubiquitous toxic heavy metal, has been widely recognized as an environmental and industrial pollutant, which confers serious threats to human health. The molecular mechanisms of the cadmium‐induced cardiotoxicity (CIC) have not been studied in human cardiomyocytes at the cellular level. Here we showed that human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) can recapitulate the CIC at the cellular level. The cadmium‐treated hPSC‐CMs exhibited cellular phenotype including reduced cell viability, increased apoptosis, cardiac sarcomeric disorganization, elevated reactive oxygen species, altered action potential profile and cardiac arrhythmias. RNA‐sequencing analysis revealed a differential transcriptome profile and activated MAPK signalling pathway in cadmium‐treated hPSC‐CMs, and suppression of P38 MAPK but not ERK MAPK or JNK MAPK rescued CIC phenotype. We further identified that suppression of PI3K/Akt signalling pathway is sufficient to reverse the CIC phenotype, which may play an important role in CIC. Taken together, our data indicate that hPSC‐CMs can serve as a suitable model for the exploration of molecular mechanisms underlying CIC and for the discovery of CIC cardioprotective drugs.

show abstract

Section: Resultssupporting

confidence: 51%

Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes

Shen

Wang

Zhou

et al. 2018

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Great hopes are thus placed on innovative compounds that would be able to significantly sensitize apoptosis‐resistant cancer cells to TRAIL. Aplysin also sensitizes the cytotoxic effects of the alkylating drug temozolomide against human glioma cells by increasing miR‐181 expression, which acts as a glioma tumor suppressor . In addition, aplysin ( 21 ) induces cell cycle arrest and apoptosis in glioma cells through the inhibition of the PI3K/Akt signaling, which plays important roles in glioma cell survival .…”

Section: Mollusk‐derived Anticancer Agentsmentioning

confidence: 99%

“…Aplysin also sensitizes the cytotoxic effects of the alkylating drug temozolomide against human glioma cells by increasing miR‐181 expression, which acts as a glioma tumor suppressor . In addition, aplysin ( 21 ) induces cell cycle arrest and apoptosis in glioma cells through the inhibition of the PI3K/Akt signaling, which plays important roles in glioma cell survival . Glioblastoma, the most malignant form of glioma, displays dismal prognoses because of major mechanisms of resistance to pro‐apoptotic stimuli …”

Section: Mollusk‐derived Anticancer Agentsmentioning

confidence: 99%

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

Ciavatta

Lefranc

Carbone

et al. 2016

Medicinal Research Reviews

View full text Add to dashboard Cite

The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as “chemotaxonomic markers” for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy. The current review highlights the diversity of chemical structures, mechanisms of action, and, most importantly, the potential of mollusk‐derived metabolites as anticancer agents, including those biosynthesized by mollusks and those of dietary origin. After the discussion of dolastatins and kahalalides, compounds previously studied in clinical trials, the review covers potentially promising anticancer agents, which are grouped based on their structural type and include terpenes, steroids, peptides, polyketides and nitrogen‐containing compounds. The “promise” of a mollusk‐derived natural product as an anticancer agent is evaluated on the basis of its ability to target biological characteristics of cancer cells responsible for poor treatment outcomes. These characteristics include high antiproliferative potency against cancer cells in vitro, preferential inhibition of the proliferation of cancer cells over normal ones, mechanism of action via nonapoptotic signaling pathways, circumvention of multidrug resistance phenotype, and high activity in vivo, among others. The review also includes sections on the targeted delivery of mollusk‐derived anticancer agents and solutions to their procurement in quantity.

show abstract

“…[ 137 ] demonstrated that aplysin ( 109 ) can enhance the effect of temozolomide (a chemotherapy drug) on glioma cells by increasing miR-181 expression. According to this, a recent study showed that aplysin ( 109 ) can actually induce apoptosis in glioma cells by interference with the HSP90/AKT pathway [ 138 ]. Moreover, a toxicological study suggested that aplysin ( 109 ) has a significant protective effect on hepatic injury in ethanol-treated rats by modulating the ethanol-metabolizing pathway, attenuating oxidative stress, ameliorating mitochondrial function, and inhibiting mitochondrial damage-mediated apoptosis, which ultimately prevent and repair alcoholic liver injury [ 139 ].…”

Section: Terpenoidsmentioning

confidence: 99%

Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus

2016

View full text Add to dashboard Cite

The marine environment is an important source of structurally-diverse and biologically-active secondary metabolites. During the last two decades, thousands of compounds were discovered in marine organisms, several of them having inspired the development of new classes of therapeutic agents. Marine mollusks constitute a successful phyla in the discovery of new marine natural products (MNPs). Over a 50-year period from 1963, 116 genera of mollusks contributed innumerous compounds, Aplysia being the most studied genus by MNP chemists. This genus includes 36 valid species and should be distinguished from all mollusks as it yielded numerous new natural products. Aplysia sea hares are herbivorous mollusks, which have been proven to be a rich source of secondary metabolites, mostly of dietary origin. The majority of secondary metabolites isolated from sea hares of the genus Aplysia are halogenated terpenes; however, these animals are also a source of compounds from other chemical classes, such as macrolides, sterols and alkaloids, often exhibiting cytotoxic, antibacterial, antifungal, antiviral and/or antifeedant activities. This review focuses on the diverse structural classes of secondary metabolites found in Aplysia spp., including several compounds with pronounced biological properties.

show abstract

Aplysin induces apoptosis in glioma cells through HSP90/AKT pathway

Cited by 17 publications

References 18 publications

Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes

Modelling cadmium‐induced cardiotoxicity using human pluripotent stem cell‐derived cardiomyocytes

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus

Contact Info

Product

Resources

About