APM1 gene variants −11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes

Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

“…They are also in agreement with data of studies of French Caucasians (Vasseur et al, 2002), Swedish Caucasians (Harvest et al, 2004), Croatian (Karmelic et al, 2012) and Chinese (Sun et al, 2008;Wanga et al, 2009;Min et al, 2011;Yang et al, 2008;Wang et al, 2009) populations.…”

Association of adiponectin gene polymorphisms and additional gene-gene interaction with nonalcoholic fatty liver disease in the Chinese Han population

“…Two common SNPs, rs266729 (-11377 C [ G) and rs1501299 (?276 G [ T), in the proximal promoter and intronic region of the ADIPOQ gene, respectively, have been widely studied by epidemiological studies. Variant alleles at rs266729, which is associated with lower adiponectin levels, have been shown to be related to obesity [10], type 2 diabetes (T2DM) [11], and insulin sensitivity [12]. Another variant, rs1501299, is correlated with decreased adiponectin expression, which might in turn lead to increased body weight and insulin resistance [13,14].…”

Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated -11,377 G adiponectin allele

“…Rather, +45 T and +276 T alleles of ADIPOQ, which were proven not to be correlated with the incidence of Korean T2DM in the present study, were reported to demonstrate a strong correlation with T2DM in Japanese and Chinese individuals. That is, in several studies, the -11,377 G allele of ADIPOQ was not associated with T2DM in Japanese and Chinese subjects (28,(44)(45)(46)(47). Of note, in Caucasoid Europeans, including French and Swedish subjects, living geographically distant from East Asia and having genetic lineages that are different from those of mongoloids, including Japanese and Chinese populations who are expected to be physically and genetically similar to Koreans, the -11,377 G allele was found to be associated with T2DM, as is the case of the Korean subjects in the present study (6,7).…”