Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

Kaftan, Ahmed N.; Hussain, Majid Kadhum

doi:10.1016/j.gene.2015.06.004

Cited by 25 publications

(14 citation statements)

References 39 publications

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“…In the Erasmus Rucphen study in Netherlands, rs17300539 was found to be associated with plasma insulin levels and HOMA-IR due to functional variation of the adiponectin protein which affected insulin sensitivity independently of adiponectin levels (54). Kaftan et al (28) found that rs266729 was associated with type 2 diabetes and also had an effect on HDL-c in an Iraqi population; however, they did not perform serum adiponectin levels. In contrast to these observations, Gao et al (55) found no association between rs266729 polymorphism and metabolic syndrome in a Chinese population which they felt was due to their small study population and additionally they did not correlate their results with serum adiponectin levels.…”

Section: Discussionmentioning

confidence: 96%

“…However, the association between the adiponectin gene polymorphisms and adiponectin levels varies across different populations and some studies have found that rs17300539 is indeed associated with increased risk of metabolic syndrome and type 2 diabetes (26). Kaftan et al (28) described that both homozygous and heterozygous mutations of rs 266729 are associated with an increased risk of type 2 diabetes in Iraqis, but that conflicting results have been found in other populations. These conflicting results of genetic studies may be due to differences in age, genetic and ethnic backgrounds of the study populations (26, 28).…”

Section: Introductionmentioning

confidence: 99%

“…Kaftan et al (28) described that both homozygous and heterozygous mutations of rs 266729 are associated with an increased risk of type 2 diabetes in Iraqis, but that conflicting results have been found in other populations. These conflicting results of genetic studies may be due to differences in age, genetic and ethnic backgrounds of the study populations (26, 28). …”

Section: Introductionmentioning

confidence: 99%

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High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-Ancestry Hyperglycemic Subjects from South Africa

Zemlin

Matsha

Kengne

et al. 2016

Journal of Medical Biochemistry

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SummaryBackgroundHigh molecular weight (HMW) adiponectin has antiatherogenic, antiinflammatory and antidiabetic properties and these effects have been linked to its effect on high density lipoprotein cholesterol (HDL-c). Single nucleotide polymorphisms (SNPs) in the adiponectin gene influence adiponectin levels. We examined the relationship between HMW-adiponectin levels and cardiometabolic traits in normo- and hyperglycemic mixed ancestry South Africans and correlated these levels to two common polymorphisms.MethodsHMW-adiponectin was determined in 101 subjects from the Cape Town Bellville South community-based study on a mixed ancestry population. Comparisons were made between individuals with normo- and hyperglycemia. Two common SNPs, ADIPOQ SNPs rs17300539 and rs266729, known to affect adiponectin levels were also tested for. Levels of HMW-adiponectin were then correlated with cardiometabolic traits in all groups.ResultsLevels of HMW-adiponectin were not significantly different in the normo- and hyperglycemic groups (median 11.6 vs. 10.5 μg/mL, p=0.3060) and in men and women (8.44 vs. 11.34 μg/mL, p=0.67). ADIPOQ SNPs rs17300539 and rs266729 did not influence levels of HMW-adiponectin. Robust correlation analyses revealed a significant positive correlation between HMW-adiponectin and HDL-c (r=0.45; 95%CI: 0.27–0.59), similarly in normo- and hyperglycemic participants (p > 0.99). This association was substantially attenuated in robust linear regressions adjusted for age, gender and adiposity.ConclusionsAdiponectin levels in this population were not determined by the commonest SNPs of the adiponectin gene, were unaffected by glycemic status; but were significantly correlated with HDL-c levels. Previous studies have attributed some of the beneficial effects of adiponectin to its effect on HDL-c.

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-Ancestry Hyperglycemic Subjects from South Africa

Zemlin

Matsha

Kengne

et al. 2016

Journal of Medical Biochemistry

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“…Previous studies performed on Jahrom city in Iran (Erfanian et al 2016), India (Khan et al 2017) and Italian population (Chiodini et al 2010) were consistent with our study. On the other hand, studies that were carried out in India (Ramya et al 2013), Finnish Diabetes Prevention Study (Siitonen et al 2011), and Iraqi population (Kaftan and Hussain 2015) showed that rs266729 had association with T2DM. In Finnish Diabetes Prevention Study, allele C of rs266729 was associated with an increased adjusted hazard ratio for developing T2DM.…”

Section: Discussionmentioning

confidence: 97%

Association between adiponectin rs17300539 and rs266729 gene polymorphisms with serum adiponectin level in an Iranian diabetic/pre-diabetic population

Karimi

Nezhadali

Hedayati

2018

Endocrine Regulations

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Objective. Adiponectin is an adipokine that is mostly secreted from adipose tissues and has a significant role in the improvement of insulin resistant and type 2 diabetes mellitus (T2DM). This study is conducted to examine the association of rs17300539 and rs266729 with T2DM and serum adiponectin level in Iranian population. Method. A case-control study was conducted on 80 individuals with fasting plasma glucose (FPG) >100 (mg/dl) as diabetic-pre-diabetic group, and 80 individuals with fasting plasma glucose 70-100 (mg/dl) as control group. DNA extraction was done on samples and genotyping method was performed by PCR-RFLP. Result. The frequency of GA genotype in rs17300539 (diabetic/pre-diabetic 35.5%, control 11.3%, (OR [95%CI]=4.18[1.8-9.6]; p=0.001) and allele A (diabetic/pre-diabetic 31%, control 9%, (OR [95% CI]=4.67[2-10.7]) was significantly more in diabetic/pre-diabetic group compared to control group. The difference in the genotype frequency for rs266729 in diabetic group compared to that in control was not significant. The levels of adiponectin in diabetic cases had no difference compared to the control group in both polymorphisms. The rs266729 was not associated with any metabolic parameter except waist circumference (p=0.03), however, rs17300539 shows association only with fasting plasma glucose, triglyceride, and total cholesterol (p=0.007, 0.039, 0.0032, respectively). Conclusion. Our findings showed that there is an association between rs17300539 with the increase of T2DM but rs266729 showed no association with the risk of T2DM. Allele A of rs17300539 increased the risk of diabetes. There is no association between adiponectin level and both polymorphisms.

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“…Так, выявлена связь полиморфных локусов гена ADIPOQ с сахарным диабетом (СД) 2-го типа, ожирением, НАЖБП, МС, сердечно-сосудистыми заболеваниями, синдромом поликистоза яичников, периодонтитом, остеоартритом колена, протоковым инфильтрирующим раком молочной железы [6]. Показано, что полиморфный вариант однонуклеотидной замены rs2241766 гена ADIPOQ, а также rs266729 и rs822395 имеют значимую ассоциацию с СД 2-го типа [7]. Более того, полиморфизм rs2241766 тесно связан не только с СД 2-го типа, но также с ожирением и МС [8].…”

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Ассоциация полиморфизма c.276G>t (rs1501299) гена ADIPOQ с неалкогольной жировой болезнью печени у лиц узбекской национальности

Sobirova¹,

Karimov²,

Иминова³

et al. 2020

EPh

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Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

Cited by 25 publications

References 39 publications

High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-Ancestry Hyperglycemic Subjects from South Africa

High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-Ancestry Hyperglycemic Subjects from South Africa

Association between adiponectin rs17300539 and rs266729 gene polymorphisms with serum adiponectin level in an Iranian diabetic/pre-diabetic population

Ассоциация полиморфизма c.276G>t (rs1501299) гена ADIPOQ с неалкогольной жировой болезнью печени у лиц узбекской национальности

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