Apnea neonatal como manifestación inicial de infección por SARS-CoV-2

Brabin, Anthony González; Iglesias-Bouzas, María Isabel; Nieto-Moro, Montserrat; Azagra-Garde, Amelia Martínez de; García-Salido, Alberto

doi:10.1016/j.anpedi.2020.05.008

Cited by 17 publications

(13 citation statements)

References 2 publications

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“…Only two neonatal infections were diagnosed by the presence of IgM in newborn blood 29,82 : these cases qualified as possible congenital and probable postpartum acquired infections, respectively, according to the classification system 16 ; all the other cases had at least one positive RT-PCR. Nine (5.1%) neonates required delivery room resuscitation 19,20,38,41,44,69,77,87 and 67 (38.3%) needed to be admitted to the NICU 17,18,20,27,31,33,35,36,38,41,44,45,[47][48][49][51][52][53][57][58][59]61,62,[64][65][66][69][70][71][72][73]77,[80][81][82][85][86][87]<...>…”

Section: Resultsmentioning

confidence: 99%

“…Clinical features of neonatal SARS-CoV-2 infections. Ninetyseven neonates presented with clinical features related to COVID-19: 18,20,[26][27][28]30,32,[34][35][36][38][39][40][41]44,45,[50][51][52]55,56,58,60,61,[65][66][67][70][71][72]77,78,80,81,[85][86][87][88]90 their distribution is shown in Table 3. Respiratory manifestations mainly consisted of signs of respiratory failure, such as tachypnoea, intercostal retractions, and rhinitis; neonatal ARDS was not diagnosed in any case.…”

Section: Resultsmentioning

confidence: 99%

“…Inflammatory markers (Creactive protein and procalcitonin) were increased in 15 (15.5%) out of 97 neonates 20,27,38,40,43,45,49,59,70,72,[80][81][82]88 . Lung imaging was abnormal in 62 (64%) out of 97 neonates and consisted of an interstitialalveolar pattern at lung ultrasound or chest X-ray and ground-glass opacities at CT-scan 17,19,21,23,27,29,32,36,38,44,45,51,53,55,58,59,[64][65][66][69][70][71]73,[77][78][79][80]82,85,88,90 . One neonate presenting with neurological manifestations also showed bilateral gliosis of the deep white periventricular and subcortical matter, together with signs of cerebral vasculitis, which was not totally remitted at the hospital discharge 77 .…”

Section: Resultsmentioning

confidence: 99%

“…Our findings confirm that SARS-CoV-2 can infect neonates and that the majority of these infections occur 17 Case report France a PR 6 Good Aghdam 18 Case report Iran PR 4 Intermediate Alonso Diaz 19 Case report Spain PR 5 Intermediate Alzamora 20 Case report Peru PR 3 Intermediate Ayed 21 Case series Kuwait Preprint 1 Low Banerjee 22 Case series India PR 2 Low Barbero 23 Retrospective cohort study Spain PR n.a. Intermediate Buonsenso 24 Case series Italy PR 4 Intermediate Carosso 25 Case report Italy PR 4 Intermediate Chacon-Aguilar 26 Case report Spain PR 5 Intermediate Coronado Munoz 27 Case report USA PR 4 Intermediate Demirjian 28 Case report UK PR 4 Intermediate Dong 29 Case report China PR 6 Good Dumpa 30 Case report USA PR 6 Good Eghbalian 31 Case report Iran PR 4 Intermediate Feng 32 Case series China PR 3 Intermediate Fenizia 33 Case series Italy PP 5 Intermediate Ferrazzi 34 Case series Italy PR 1 Low Garazzino 35 Case series Italy PR 2 Low Gonzales Brabin 36 Case report Spain PR 3 Intermediate Gordon 37 Case report UK PR 2 Low Gregorio-Hernandez 38 Case series Spain PR 5 Intermediate Groß 39 Case series Germany PR 5 Intermediate Han 40 Case report South Korea PR 6 Good Hantoushzadeh 41 Case series Iran PR 6 Good Hasan 42 Case series Bangladesh Preprint 6 Good Hu 43 Case series China PR 6 Good Ibarra Rios 44 Case report Mexico Preprint 5 Intermediate Kanburoglu 45 Case report Turkey PR 1 Low Kayem 46 Case series France PR 1 Low Kirtsman 47 Case report Canada PR 6 Good Knight 48 Retrospective cohort study UK PR n.a. n.a.…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

et al. 2020

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A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08), p = 0.0002; adjusted OR 6.6 (95% CI: 2.6–16), p < 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09–1.18), p = 0.10; adjusted OR 2.2 (95% CI: 0.7–6.5), p = 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

et al. 2020

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“…To our best knowledge, very few articles have mentioned apneas associated with COVID-19 in children (22)(23)(24). The other symptoms presented by this child: dry cough, moderate rhinitis, fatigue, although non-specific, are commonly reported in the literature for COVID-19 infections (25).…”

Section: Discussionmentioning

confidence: 85%

COVID-19 Associated With Life-Threatening Apnea in an Infant Born Preterm: A Case Report

et al. 2020

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A pandemic linked to the new coronavirus strain (SARS-CoV-2) has been raging for several months. Pediatric populations are less impacted than adults, and critical respiratory diseases seem rare (1, 2). We report the case of an infant, who presented with life-threatening apneas at home requiring basic life support. SARS-CoV-2 was subsequently identified in the patient's nasopharyngeal aspirate. He did not present with bronchiolitis or hypoxic failure as described in severe forms of COVID−19. The outcome was favorable in a few hours. The occurrence of apneas is not uncommon during viral respiratory infections in early infancy; however, there are very few descriptions related to a documented SARS-CoV-2 respiratory tract infection. In light of this clinical case, it seems necessary to quickly bring up a potential COVID-19 contamination in infants admitted for life-threatening apnea, in order to properly report and isolate these patients to avoid further nosocomial dissemination of SARS-CoV-2.

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SARS‐CoV‐2 acute bronchiolitis in hospitalized children: Neither frequent nor more severe

Andina-Martínez

Cadenas

Cobos‐Carrascosa

et al. 2021

Pediatric Pulmonology

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Introduction: Endemic coronaviruses have been found in acute bronchiolitis, mainly as a coinfecting virus. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for respiratory illness in hospitalized children. The characteristics of patients with bronchiolitis have not been extensively described.Methods: Cross-sectional study of patients with bronchiolitis and SARS-CoV-2 infection enrolled in a prospective multicenter cohort of children hospitalized with

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Apnea neonatal como manifestación inicial de infección por SARS-CoV-2

Cited by 17 publications

References 2 publications

Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

Synthesis and systematic review of reported neonatal SARS-CoV-2 infections

COVID-19 Associated With Life-Threatening Apnea in an Infant Born Preterm: A Case Report

SARS‐CoV‐2 acute bronchiolitis in hospitalized children: Neither frequent nor more severe

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