Apo E Gene Polymorphism Affects Development of Type 2 Diabetic Nephropathy in Asian Populations, Especially in East Asians: An Updated Meta-Analysis

Wu, Yao-jun

doi:10.12659/msm.892111

Cited by 12 publications

(2 citation statements)

References 23 publications

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“…However, the initial selection should be performed for the combinational results of GWAS and meta-analyses, along with genetic association with strong statistical support; at the same time, GWAS and metaanalyses showed convincing sizes effects are moderate in current platforms, as sample sizes can still explain the majority of large genetic risk for most common diseases (Zeggini & Ioannidis, 2009). Meta-analysis studies on the ApoE gene in relation to multiple diseases revealed both were positive (Arati et al, 2016;Cao et al, 2014;Garatachea et al, 2015;Gatt et al, 2015;Han et al, 2013;Li et al, 2015;Liao et al, 2014;Lin et al, 2014;Meng et al, 2013;Rubino et al, 2013;Sun et al, 2015;Wang et al, 2014;Yin et al, 2012;Yin et al, 2013;Yin et al, 2014;Zhang et al, 2014a;Zhang et al, 2014b;Zhang et al, 2015), and negative associations (Agarwal & Tripathi, 2014;Gu et al, 2013;Liu et al, 2014;Miao et al, 2015;Stoumpos et al, 2013;Tian et al, 2014;Xu et al, 2015;Zhao et al, 2016;Zhu et al, 2016). Earlier reports in the nineties did not provide unequivocal conclusions regarding the relation of the ApoE gene and FH in different populations (Carmena et al, 1993;Friedlander & Leitersdorf, 1996;Utermann et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study

et al. 2018

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Familial Hypercholesterolemia (FH) is characterized by elevated cholesterol; this is based on biochemical, clinical, and genetic studies and FH disease, which was documented even with limited mutations. Earlier studies were associated with Apolipoprotein E (ApoE) in variable diseases. The current study aims to investigate the genetic association between FH disease and ApoE gene (rs429358 and rs7412) in the Saudi population. This study has been carried out as a case-control and is a hospital-based study in Saudi Arabia. Two hundred and four subjects were recruited as FH participants (n=104) and the others as controls (n=100). Common polymorphisms (rs429358 and rs7412) were selected from the ApoE gene and we then performed the genotyping as the TaqMan assay. Moreover, the ApoE risk allele E4 is significantly associated in FH cases and controls (OR-2.24 (95%CI: 1.06-4.70); p=0.02). Lipid profile parameters were significantly associated (p<0.05); however, a combination of ApoE alleles and lipid profiles could not find a correlation (p>0.05). The FH case-control study was associated with the E4 allele in the Saudi population. The risk of allele E4 which is a reliable marker for lipid profiles, but did not correlate with ApoE alleles.

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Section: Discussionmentioning

confidence: 99%

Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study

et al. 2018

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“…In recent studies, the Fabp4 and Pten gene expression and correlation in the liver, muscle, and adipose tissues of type 2 diabetes mellitus (T2DM) rats was shown to be increased, suggesting that the increased expression of PTEN and FABP4 may play an important role in the insulin resistance of T2DM [ 42 ]. In another study, the correlation between the Apolipoprotein E (APO E) gene polymorphisms and diabetic nephropathy was investigated, and it was suggested that development of diabetic neuropathy was associated with APO E polymorphisms in Asian populations [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Exenatide Alters Gene Expression of NCAM, ICAM, and VCAM in the Hippocampus of Type 2 Diabetic Model Mice

et al. 2016

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BackgroundGlucagon-like peptide-1 (GLP-1), a potent and selective agonist for the GLP-1 receptor, ameliorates the symptoms of diabetes through stimulation of insulin secretion. Exenatide is a potent and selective agonist for the GLP-1 receptor. Cell adhesion molecules are members of the immunoglobulin superfamily and are involved in synaptic rearrangements in the mature brain.Material/MethodsThe present study demonstrated the effects of exenatide treatment (0.1 μg/kg, subcutaneously, twice daily for 2 weeks) on the gene expression levels of cell adhesion molecules, neural cell adhesion molecule (NCAM), intercellular cell adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in the brain tissue of diabetic BALB/c male mice by real-time quantitative polymerase chain reaction (PCR). Diabetes was induced by streptozotocin/nicotinamide (STZ-NA) injection to male mice.ResultsThe results of this study revealed that hippocampal gene expression of NCAM, ICAM, and VCAM were found to be up-regulated in STZ-NA-induced diabetic mice compared to those of controls. A significant decrease in the gene expression levels of NCAM, ICAM, and VCAM were determined after 2 weeks of exenatide administration.ConclusionsCell adhesion molecules may be involved in the molecular mechanism of diabetes. Exenatide has a strong beneficial action in managing diabetes induced by STZ/NA by altering gene expression of NCAM, ICAM, and VCAM.

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Apolipoprotein E genotyping in Egyptian diabetic nephropathy patients

et al. 2015

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Research for the causes of diabetic nephropathy has focused on the study of the affected familial disease clusters. The polymorphism in apolipoprotein E (ApoE) has been linked to the development of diabetic nephropathy (DN) in association with hyperlipidemia. The aim of this study was to evaluate the association of this condition with ApoE gene polymorphism connected with DN in diabetic Egyptian subjects. One hundred and thirty-five patients were enrolled in the study, they were divided into three groups: 45 diabetic patients; 45 DN patients and 45 healthy control group. Clinical examination and routine laboratory investigations with serum lipids and urinary microalbumin were done. Peripheral blood leukocytes from all were examined by the polymerase chain reaction for polymorphisms in ApoE gene. Our results revealed significant difference between Apo E genotype frequencies among all studied groups. Genotypes e2e3 and e2e4 were reported to be significantly higher in diabetes as compared to control individuals while genotype e3e3 was higher in control as compared to diabetes. Among the entire diabetic group e2e3 was highly detected in DN. Regarding allelic frequency e2 allele was significantly detected in DN patients as compared to diabetic patients and it was the lowest in control individuals. In conclusion Apo e2 mutations may have a role in increasing the development of DN among the Egyptian individuals. V C 2015 IUBMB Life, 68(1): [58][59][60][61][62][63][64] 2016

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Apo E Gene Polymorphism Affects Development of Type 2 Diabetic Nephropathy in Asian Populations, Especially in East Asians: An Updated Meta-Analysis

Cited by 12 publications

References 23 publications

Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study

Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study

Exenatide Alters Gene Expression of NCAM, ICAM, and VCAM in the Hippocampus of Type 2 Diabetic Model Mice

Apolipoprotein E genotyping in Egyptian diabetic nephropathy patients

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