Apolipoprotein E genotyping in Egyptian diabetic nephropathy patients

Atta, Mohamed I.; Gabal, Khadiga Abo; El-Hadidi, Khalid; Swellam, Menha; Genina, Ashraf; Zaher, Nabil F.

doi:10.1002/iub.1460

Cited by 9 publications

(4 citation statements)

References 23 publications

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“…The inconsistency may result from the difference of included population, sample size, and genotyping methods. Moreover, 18 new papers (CHEN 2006;TANG et al 2007;ERDOGAN et al 2009;AL-MAJED et al 2011;CHAUDHARY et al 2012;MUSTAPIC et al 2012;GE et al 2013;RONG et al 2013;SUN et al 2013a;XIONG et al 2013;ALHARBI et al 2014;LIU 2014;WANG et al 2014;ATTA et al 2016;LIU et al 2016;LUO et al 2016;MEHMET et al 2016;LIANG et al 2017) have been published since the publication of latest meta-analysis of the association between ApoE gene polymorphism and T2DM in 2014 (YIN et al 2014). Therefore, we enrolled these new published articles, and performed a further meta-analysis to investigate whether ApoE polymorphism is associated with the increased risk of T2DM.…”

Section: Introductionmentioning

confidence: 99%

Association betweenApoEpolymorphism and type 2 diabetes: A meta-analysis of 59 studies

Chen

Shi

et al. 2019

Preprint

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1) Aims: Due to the ever increasing incidence of T2DM, it is estimated that only half of the 79 million adults with type 2 diabetes (T2DM) will have adequate access to insulin by 2030 if the current levels of access is not improved. It is urgent to identify the important risk factors for T2DM and develop effective strategies to address the problem of T2DM. Our study aimed to evaluate the association between apolipoprotein E (ApoE) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2DM and even molecular marker of targeted therapy for the treatment of T2DM.(2) Methods: Case-control studies of ApoE polymorphism and T2DM, which were included in PubMed, Web of Science, Medline, WanFang, VIP, and CNKI databases, were selected and evaluated according to criteria of inclusion and exclusion. Eligible data were extracted and pooled, and were analyzed and assessed using R soft-ware (version 3.4.3). Random-effect models were used when heterogeneity existed in between-study, and fixed-effect models were applied otherwise.(3) Results: A total of 59 studies that consisted of 6,872 cases with T2DM and 8,250 controls were selected. Alleles and genotypes of ApoE between cases and controls were compared. For ApoE alleles, we observed the contrast of ε4 versus ε3 allele yielding a pooled OR of 1.18 (95% CI: 1.09-1.28; P<0.001). For ApoE genotypes, compared with ε3/ε3 genotype, ε2/ε2 genotype showed a possible association with T2DM (OR=1.46; 95% CI： 1.11-1.93； P=0.007), ε3/ε4 genotype had a 1.11-fold risk of developing T2DM (OR=1.11; 95% CI：1.01-1.22；P=0.039), and ε4/ε4 genotype had a 1.71-fold risk of developing T2DM (OR=1.71；95% CI：1. 33-2.19；P<0.001).(4) Conclusions: There is an association between ApoE polymorphism and T2DM: allele ε4 and genotypes (ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2DM, and they may be risk factors for T2DM.

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Section: Introductionmentioning

confidence: 99%

Association betweenApoEpolymorphism and type 2 diabetes: A meta-analysis of 59 studies

Chen

Shi

et al. 2019

Preprint

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“…Epidemiology studies showed that the occurrence of DN is affected by the combined actions of multiple factors [5,6]. Among these factors, genetic factors play a crucial role in DN onset, and many genes are found [7,8].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

Pei

Xue

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Purpose: This study was aimed to study the hypothesis that forkhead box O1 (FOXO1) gene rs17446614 and rs17592236 single nucleotide polymorphisms (SNPs) influenced the development of diabetic nephropathy (DN). Methods: This study included 138 DN patients and 149 healthy controls. Controls were matched with the patients in age and gender. The method of polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) was used to detect FOXO1 gene polymorphisms. Haploview software was conducted to analyze the linkage disequilibrium and haplotypes of FOXO1 gene polymorphisms. Relative risk of DN was expressed by odds ratios (ORs) and 95% confidence intervals (95% CIs), then the results were adjusted by clinical characteristics of the study subjects using logistic regression analysis. Subgroup analysis was performed according to gender. Results: AA genotype of rs17446614 SNPs was significantly associated with the risk of DN (P ¼ .037, adjusted OR ¼ 5.412, 95% CI ¼ 1.103-26.559), especially in female (OR ¼ 8.700, 95% CI ¼ 1.008-75.062, P ¼ .021). FOXO1 rs17446614 A allele positively associated with the development of DN (P ¼ .027, adjusted OR ¼ 1.680, 95% CI ¼ 1.060-2.662), particularly in women (OR ¼ 2.003, 95% CI ¼ 1.070-3.749, P ¼ .028). A-C haplotype formed by FOXO1 gene rs17446614 and rs17592236 SNPs was significantly associated with the increased risk of DN (P ¼ .011, OR ¼ 1.850, 95% CI ¼ 1.146-2.986). Conclusion: FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN.

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“…Our study revealed that E2/E3 genotype and ε2 allele were independent risk factors for DN, while the E3/E3 genotype and ε3 allele were protective factors, consistent with the previous research. 38,[52][53][54] APOE gene polymorphism significantly influenced serum lipid profiles in DN patients. APOE is a crucial plasma protein primarily synthesized, secreted, and metabolized by the liver, and it was synthesized in many other organs, including adrenal gland and kidney.…”

Section: Discussionmentioning

confidence: 99%

Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population

Gan,

Zhang,

Zhang

et al. 2023

IJGM

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Background Common polymorphisms within the apolipoprotein E (APOE) gene are rs429358 and rs7412, which result in three major alleles (ɛ2, ɛ3, and ɛ4) and six genotypes (E2/E2, E2/E3, E3/E3, E3/E4, E4/E4, and E2/E4). Although APOE gene polymorphisms have been suggested to be associated with the development of diabetic nephropathy (DN), their potential association remains unclear in different regions. This study aims to unveil the genetic effects of APOE gene polymorphisms on DN susceptibility and serum lipid profiles in southern Chinese population. Methods A total of 306 DN patients and 483 type 2 diabetic patients as controls were included in the study. The APOE gene polymorphisms were analyzed by polymerase chain reaction (PCR) microarray gene chip. Relevant medical records and information of these participants were collected. Results There were statistically significant differences ( p < 0.05) in gender, SBP, hypertension, hyperuricemia, UTP, TG and HDL-C between DN patients and controls. DN patients exhibited a higher frequency of the ε2 allele and E2/E3 genotype than controls ( p < 0.001). Logistic regression analysis indicated that the ε2 allele and E2/E3 genotype were independent risk factors (adjusted OR: 3.237, 95% CI: 1.789–5.854, p < 0.001; adjusted OR: 3.453, 95% CI: 1.873–6.368, p < 0.001), while the ε3 allele or E3/E3 genotype might serve as protective role (adjusted OR: 0.395, 95% CI: 0.255–0.612, p < 0.001) for development of DN. Conclusion Our study indicates a correlation between APOE polymorphisms and DN in the southern Chinese Hakka population. Specifically, individuals carrying the APOE ε2 allele and E2/E3 genotype are at a higher risk of developing DN. Conversely, those with the APOE ε3 allele and E3/E3 genotype have a lower risk of DN in southern Chinese population.

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Apolipoprotein E genotyping in Egyptian diabetic nephropathy patients

Cited by 9 publications

References 23 publications

Association betweenApoEpolymorphism and type 2 diabetes: A meta-analysis of 59 studies

Association betweenApoEpolymorphism and type 2 diabetes: A meta-analysis of 59 studies

RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk

Association of Apolipoprotein E Gene Polymorphism with Type 2 Diabetic Nephropathy in the Southern Chinese Population

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