apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53

Abstract

2010) apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53 , Cell Cycle, 9:18, 3785-3794, these authors contributed equally to this work.

Effects of harmaline on cell growth of human liver cancer through the p53/p21 and Fas/FasL signaling pathways

“…The p53 protein is a 53 kDa protein that serves a role in several core cellular processes, including transcription, DNA repair, the cell cycle, genome stability, chromosomal separation, apoptosis and vascularization. Under normal conditions, p53 is expressed at a low level (18). Mutations in the gene encoding p53 have been identified in various types of human cancer, including HLC (18).…”

“…Under normal conditions, p53 is expressed at a low level (18). Mutations in the gene encoding p53 have been identified in various types of human cancer, including HLC (18). Activation of the gene encoding p53 is associated with changes in various cell activities and surroundings, including the following: Increased sensitivity to DNA damage induced by UV-light, gamma rays, X-rays and topoisomerase; cell stress (anoxia and decreased cell adhesion) (18)(19)(20).…”

“…Mutations in the gene encoding p53 have been identified in various types of human cancer, including HLC (18). Activation of the gene encoding p53 is associated with changes in various cell activities and surroundings, including the following: Increased sensitivity to DNA damage induced by UV-light, gamma rays, X-rays and topoisomerase; cell stress (anoxia and decreased cell adhesion) (18)(19)(20). Following DNA damage and prior to DNA replication, the development of neoplasia can be prevented through DNA repair, apoptosis and/or G 1 /S arrest, which the p53 signaling pathway can regulate (18,19).…”

“…Activation of the gene encoding p53 is associated with changes in various cell activities and surroundings, including the following: Increased sensitivity to DNA damage induced by UV-light, gamma rays, X-rays and topoisomerase; cell stress (anoxia and decreased cell adhesion) (18)(19)(20). Following DNA damage and prior to DNA replication, the development of neoplasia can be prevented through DNA repair, apoptosis and/or G 1 /S arrest, which the p53 signaling pathway can regulate (18,19). The results from the present study demonstrated that harmaline significantly increases p53 protein expression in HepG2 cells, indicating that harmaline affects the p53 signaling pathway.…”

Mouse models of testicular germ cell tumors

“…CENP-E is described in mice as tumor-suppressing or -promoting factor depending on the context (Weaver et al, 2007). Interestingly, TRP53 has been associated with DNA demethylation (Ashur-Fabian et al, 2010) and several TRP53-target genes show aberrant methylation pattern in TGCTs in humans (Christoph et al, 2007).…”