ApoB/ApoA1 ratio and non-HDL-cholesterol/HDL-cholesterol ratio are associated to metabolic syndrome in patients with type 2 diabetes mellitus subjects and to ischemic cardiomyopathy in diabetic women

Reynoso-Villalpando, Gabriela Lizet; Sevillano-Collantes, Cristina; Valle, Yeminia; Moreno-Ruiz, Inmaculada; Padilla-Gutiérrez, Jorge Ramón; Cañizo-Gómez, Francisco Javier del

doi:10.1016/j.endinu.2019.03.019

Cited by 11 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with the result of the present study, rs662799 of APOA5 has been reported to increase the risk of MetS in Caucasians [32], Japanese [33], Koreans [34], and Chinese [35,36]. APOA1 is a primary lipoprotein associated with serum HDL concentrations in T2DM [37], and rs5072 of APOA1 is related to dyslipidemia in a gender-specific manner, as shown in the present study [38]. SIK3 plays crucial mediating roles in the three essential cancer signalings: cell proliferation, inflammation, and metastasis [39], and has been related to anti-inflammatory activity [40] and chronic inflammation.…”

Section: Discussionsupporting

confidence: 92%

Associations of Polygenetic Variants at the 11q23 Locus and Their Interactions with Macronutrient Intake for the Risk of 3GO, a Combination of Hypertension, Hyperglycemia, and Dyslipidemia

Zhou

Park

2021

JPM

View full text Add to dashboard Cite

3GO is a condition in which hypertension, hyperglycemia, and dyslipidemia co-occur, and these conditions are related to each other and genetic and environmental factors. We hypothesized that common genetic variants and their interactions with lifestyles influenced 3GO risk. We aimed to explore common genetic variants to affect 3GO risk and their haplotype interaction with lifestyles in a city hospital-based cohort in 58,701 Koreans > 40 years. 3GO was defined as SBP ≥ 140 mmHg and DBP ≥ 90 mmHg for hypertension, fasting blood glucose ≥ 126 mg/dL for hyperglycemia, and LDL ≥ 160 mg/dL or HDL ≤ 40 mg/dL, or triglyceride ≥ 200 mg/dL for dyslipidemia. Haplotypes were generated by genetic variants selected from genome-wide association study ((GWAS) an observational study of the genetic variation of the whole genome in different individuals, used to see if any variation is related to traits) after adjusting for age, sex, area of residence, and body mass index (BMI). Nutrient intakes were assessed using food frequency questionnaires. Interactions between haplotype and lifestyles and 3GO risk were investigated. Parameters related to metabolic syndrome were significantly different in the 0GO, 1–2GO, and 3GO groups, that is, groups of individuals with none, one to two, or all three of the components of 3GO. At the 11q23 locus, KCNQ1_rs2237892, ZPR1_rs2075291, APOA5_rs662799, APOA1_rs5072, and SIK3_rs151139277, influenced 3GO risk, and the minor alleles of their haplotype had a 3GO risk 3.23 times higher than the major alleles. For subjects with a high energy intake, the 3GO risk of the minor alleles was significantly higher than that of the major alleles (OR = 3.230, 95% confidence interval (CI) = 2.062~5.061, p < 0.001). BMI, HbA1c, SBP, and serum concentrations of glucose, HDL, and triglyceride were significantly higher for the minor allele than the major alleles (p < 0.001). The haplotype interacted with the intakes of protein (p = 0.033), digestible carbohydrate (p = 0.012), fat (p = 0.008), and undigestible carbohydrates (p = 0.015) to increase 3GO risk. An interaction was also observed between smoking and the haplotype (p = 0.007). The minor allele effects on 3GO incidence were higher in the high digestible carbohydrate intake and smoking groups. By contrast, the minor allele impacts on 3GO frequencies were much higher in the low intake of undigestible carbohydrates, protein, and fat. In conclusion, people who carry a minor allele of the 11q23 locus haplotype should avoid smoking and replace digestible carbohydrate intake with consuming high-quality protein, healthy fat, and undigestible carbohydrates.

show abstract

Section: Discussionsupporting

confidence: 92%

Associations of Polygenetic Variants at the 11q23 Locus and Their Interactions with Macronutrient Intake for the Risk of 3GO, a Combination of Hypertension, Hyperglycemia, and Dyslipidemia

Zhou

Park

2021

JPM

View full text Add to dashboard Cite

show abstract

“…Thus, the ApoB100/ApoA1 ratio represents the balance between atherogenic and anti-atherogenic lipoproteins. Since several studies have reported that this ratio is associated with MetS risk independently of conventional risk factors [44,45], we argue that the 4-week consumption of DHA-enriched BEF decreased the risk of MetS.…”

Section: Discussionmentioning

confidence: 74%

DHA-Induced Perturbation of Human Serum Metabolome. Role of the Food Matrix and Co-Administration of Oat β-glucan and Anthocyanins

et al. 2019

View full text Add to dashboard Cite

Docosahexaenoic acid (DHA) has been reported to have a positive impact on many diet-related disease risks, including metabolic syndrome. Although many DHA-enriched foods have been marketed, the impact of different food matrices on the effect of DHA is unknown. As well, the possibility to enhance DHA effectiveness through the co-administration of other bioactives has seldom been considered. We evaluated DHA effects on the serum metabolome administered to volunteers at risk of metabolic syndrome as an ingredient of three different foods. Foods were enriched with DHA alone or in combination with oat beta-glucan or anthocyanins and were administered to volunteers for 4 weeks. Serum samples collected at the beginning and end of the trial were analysed by NMR-based metabolomics. Multivariate and univariate statistical analyses were used to characterize modifications in the serum metabolome and to evaluate bioactive-bioactive and bioactive-food matrix interactions. DHA administration induces metabolome perturbation that is influenced by the food matrix and the co-presence of other bioactives. In particular, when co-administered with oat beta-glucan, DHA induces a strong rearrangement in the lipoprotein profile of the subjects. The observed modifications are consistent with clinical results and indicate that metabolomics represents a possible strategy to choose the most appropriate food matrices for bioactive enrichment.

show abstract

“…McCullough et al 48 reported that androgens can significantly reduce high-density lipoprotein and increase low-density lipoprotein, and the increase of low-density lipoprotein levels can promote the formation of atherosclerosis.The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio is an important indicator for preventing the occurrence and development of cardiovascular disease. 49 , 50 If it increases, the risk of cardiovascular disease increases.Androgens that lead to acneigenesis can also lead to elevated ApoB/ApoA1. 51 Studies have found that IL-17, TNF-α, Toll-like receptors, and NF-κB pathways are actively involved in the occurrence and development of cardiovascular diseases, 52–55 and these targets and pathways are also involved in the occurrence and development of acne.…”

Section: The Relationship Between Acne and Various Metabolic Diseasesmentioning

confidence: 99%

Acne Comorbidities

Wang¹,

Zhu²,

Wu³

et al. 2022

CCID

View full text Add to dashboard Cite

Acne vulgaris is a multifactorial chronic inflammatory disorder of the pilosebaceous unit, and it represents the most common skin disease affecting about 85% of adolescents in Western populations. The prevalence of acne vulgaris in developed countries is higher than that in developing countries.Emerging data has shown some systemic diseases closely associated with acne, including obesity, diabetes mellitus, cardiovascular diseases, metabolic syndrome (Mets), and so on.This review summarizes acneassociated diseases that have been reported in studies, and analyzes the possible co-pathogenesis of these diseases and acne.

show abstract

ApoB/ApoA1 ratio and non-HDL-cholesterol/HDL-cholesterol ratio are associated to metabolic syndrome in patients with type 2 diabetes mellitus subjects and to ischemic cardiomyopathy in diabetic women

Cited by 11 publications

References 31 publications

Associations of Polygenetic Variants at the 11q23 Locus and Their Interactions with Macronutrient Intake for the Risk of 3GO, a Combination of Hypertension, Hyperglycemia, and Dyslipidemia

Associations of Polygenetic Variants at the 11q23 Locus and Their Interactions with Macronutrient Intake for the Risk of 3GO, a Combination of Hypertension, Hyperglycemia, and Dyslipidemia

DHA-Induced Perturbation of Human Serum Metabolome. Role of the Food Matrix and Co-Administration of Oat β-glucan and Anthocyanins

Acne Comorbidities

Contact Info

Product

Resources

About